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Volumn 1, Issue 7, 2014, Pages 510-521

Genomic quantitative real-time PCR proves residual disease positivity in more than 30% samples with negative mRNA-based qRT-PCR in Chronic Myeloid Leukemia

Author keywords

Chronic myeloid leukemia; DNA Q PCR; Leukemic stem cells; Minimal residual disease; Stop imatinib

Indexed keywords


EID: 84927912595     PISSN: None     EISSN: 23314737     Source Type: Journal    
DOI: 10.18632/oncoscience.65     Document Type: Article
Times cited : (31)

References (72)
  • 1
    • 77949442316 scopus 로고    scopus 로고
    • Monitoring disease response to tyrosine kinase inhibitor therapy in CML
    • Hughes TP, Branford S. Monitoring disease response to tyrosine kinase inhibitor therapy in CML. Hematology Am Soc Hematol Educ Program 2009, 1: 477-487.
    • (2009) Hematology Am Soc Hematol Educ Program , vol.1 , pp. 477-487
    • Hughes, T.P.1    Branford, S.2
  • 3
    • 84878574628 scopus 로고    scopus 로고
    • Ponatinib circumvents all types of imatinib resistance in chronic myelogenous leukemia cell lines
    • Dufies M, Cassuto O, Jacquel A, Robert G, Auberger P. Ponatinib circumvents all types of imatinib resistance in chronic myelogenous leukemia cell lines. Cell Cycle. 2013, 12(11): 1645-6.
    • (2013) Cell Cycle , vol.12 , Issue.11 , pp. 1645-1646
    • Dufies, M.1    Cassuto, O.2    Jacquel, A.3    Robert, G.4    Auberger, P.5
  • 6
    • 84876130803 scopus 로고    scopus 로고
    • Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitorresistant chronic myeloid leukemias
    • Tobin LA, Robert C, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, Rassool FV. Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitorresistant chronic myeloid leukemias. Oncogene. 2013, 32(14): 1784-93.
    • (2013) Oncogene , vol.32 , Issue.14 , pp. 1784-1793
    • Tobin, L.A.1    Robert, C.2    Rapoport, A.P.3    Gojo, I.4    Baer, M.R.5    Tomkinson, A.E.6    Rassool, F.V.7
  • 7
    • 84887468047 scopus 로고    scopus 로고
    • PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor
    • Airiau K, Mahon FX, Josselin M, Jeanneteau M, Belloc F. PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor. Cell Death Dis. 2013, 4: e827.
    • (2013) Cell Death Dis , vol.4
    • Airiau, K.1    Mahon, F.X.2    Josselin, M.3    Jeanneteau, M.4    Belloc, F.5
  • 8
    • 78751680957 scopus 로고    scopus 로고
    • Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET
    • Shibata Y, Malhotra A, Dutta A. Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET. Genome Med 2010, 2: 70.
    • (2010) Genome Med , vol.2 , pp. 70
    • Shibata, Y.1    Malhotra, A.2    Dutta, A.3
  • 9
    • 83755171527 scopus 로고    scopus 로고
    • Measuring response to BCR-ABL inhibitors in chronic myeloid leukemia
    • Radich JP. Measuring response to BCR-ABL inhibitors in chronic myeloid leukemia. Cancer 2012, 118: 300-301.
    • (2012) Cancer , vol.118 , pp. 300-301
    • Radich, J.P.1
  • 10
    • 70350717760 scopus 로고    scopus 로고
    • How I monitor residual disease in chronic myeloid leukemia
    • Radich JP. How I monitor residual disease in chronic myeloid leukemia. Blood 2009, 114: 3376-3381.
    • (2009) Blood , vol.114 , pp. 3376-3381
    • Radich, J.P.1
  • 12
    • 84880400129 scopus 로고    scopus 로고
    • Chronic growth factor receptor signaling and lineage inappropriate gene expression in AML: the polycomb connection
    • Ray D, Kwon SY, Ptasinska A, Bonifer C. Chronic growth factor receptor signaling and lineage inappropriate gene expression in AML: the polycomb connection. Cell Cycle. 2013, 12(14): 2159-60.
    • (2013) Cell Cycle , vol.12 , Issue.14 , pp. 2159-2160
    • Ray, D.1    Kwon, S.Y.2    Ptasinska, A.3    Bonifer, C.4
  • 13
    • 84879336004 scopus 로고    scopus 로고
    • Adding a new facet to STAT5 in CML: multitasking for leukemic cells
    • Warsch W, Grundschober E, Sexl V. Adding a new facet to STAT5 in CML: multitasking for leukemic cells. Cell Cycle. 2013, 12(12): 1813-4.
    • (2013) Cell Cycle , vol.12 , Issue.12 , pp. 1813-1814
    • Warsch, W.1    Grundschober, E.2    Sexl, V.3
  • 19
    • 41349123259 scopus 로고    scopus 로고
    • Monitoring the response of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: pratical advice on the use and interpretation of monitoring methods
    • Kantarjian H, Schiffer C, Jones D, Cortes J. Monitoring the response of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: pratical advice on the use and interpretation of monitoring methods. Blood 2008, 111: 1774-1780.
    • (2008) Blood , vol.111 , pp. 1774-1780
    • Kantarjian, H.1    Schiffer, C.2    Jones, D.3    Cortes, J.4
  • 20
    • 13244262939 scopus 로고    scopus 로고
    • Monitoring minimal residual disease in BCR-ABL-positive chronic myeloid leukemia in the imatinib era
    • Goldman J. Monitoring minimal residual disease in BCR-ABL-positive chronic myeloid leukemia in the imatinib era. Curr Opin Hematol 2005, 12: 33-39.
    • (2005) Curr Opin Hematol , vol.12 , pp. 33-39
    • Goldman, J.1
  • 22
    • 77956545790 scopus 로고    scopus 로고
    • In search of the original leukemic clone in chronic myeloid leukemia patients in complete molecular remission after stem cell transplantation or imatinib
    • Sobrinho-Simoes M, Wilczek V, Score J, Cross NC, Apperley JF, Melo JV. In search of the original leukemic clone in chronic myeloid leukemia patients in complete molecular remission after stem cell transplantation or imatinib. Blood 2010, 116: 1329-1335.
    • (2010) Blood , vol.116 , pp. 1329-1335
    • Sobrinho-Simoes, M.1    Wilczek, V.2    Score, J.3    Cross, N.C.4    Apperley, J.F.5    Melo, J.V.6
  • 23
    • 84867405606 scopus 로고    scopus 로고
    • Standardized definitions of molecular response in chronic myeloid leukemia
    • Cross NCP, White HE, Muller MC, Saglio G, Hochlaus. Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 2012, 26: 2172-2175.
    • (2012) Leukemia , vol.26 , pp. 2172-2175
    • Cross, N.C.P.1    White, H.E.2    Muller, M.C.3    Saglio, G.4    Hochlaus, A.5
  • 25
    • 81555214617 scopus 로고    scopus 로고
    • Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
    • Chu S, McDonald T, Lin A, Chakraborty S, Huang Q, Snyder DS, Bhatia R. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment. Blood 2011, 118: 5565-5572.
    • (2011) Blood , vol.118 , pp. 5565-5572
    • Chu, S.1    McDonald, T.2    Lin, A.3    Chakraborty, S.4    Huang, Q.5    Snyder, D.S.6    Bhatia, R.7
  • 26
    • 78049528573 scopus 로고    scopus 로고
    • Intergroupe Français des Leucémies Myéloïdes Chroniques. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicenter Stop Imatinib (STIM) trial
    • Mahon FX, Réa D, Guilhot J, Guilhot F, Huguet F, Nicolini F, Legros L, Charbonnier A, Guerci A, Varet B, Etienne G, Reiffers J, Rousselot P; Intergroupe Français des Leucémies Myéloïdes Chroniques. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicenter Stop Imatinib (STIM) trial. Lancet Oncol 2010, 11: 1029-1035.
    • (2010) Lancet Oncol , vol.11 , pp. 1029-1035
    • Mahon, F.X.1    Réa, D.2    Guilhot, J.3    Guilhot, F.4    Huguet, F.5    Nicolini, F.6    Legros, L.7    Charbonnier, A.8    Guerci, A.9    Varet, B.10    Etienne, G.11    Reiffers, J.12    Rousselot, P.13
  • 27
    • 84872334998 scopus 로고    scopus 로고
    • Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia
    • Horn M, Glauche I, Müller MC, Hehlmann R, Hochhaus A, Loeffler M, Roeder I. Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Blood 2013, 121: 378-384.
    • (2013) Blood , vol.121 , pp. 378-384
    • Horn, M.1    Glauche, I.2    Müller, M.C.3    Hehlmann, R.4    Hochhaus, A.5    Loeffler, M.6    Roeder, I.7
  • 28
    • 84870697761 scopus 로고    scopus 로고
    • Implementation of management guidelines for chronic myeloid leukemia: perspectives in the United States
    • Rizzieri D, Moore JO. Implementation of management guidelines for chronic myeloid leukemia: perspectives in the United States. P T 2012, 37: 640-648.
    • (2012) P T , vol.37 , pp. 640-648
    • Rizzieri, D.1    Moore, J.O.2
  • 29
    • 70249092623 scopus 로고    scopus 로고
    • Molecular monitoring of residual disease in chronic myeloid leukemia by genomic DNA compared with conventional mRNA analysis
    • Mattarucchi E, Spinelli O, Rambaldi A, Pasquali F, Lo Curto F, Campiotti L, Porta G. Molecular monitoring of residual disease in chronic myeloid leukemia by genomic DNA compared with conventional mRNA analysis. J Mol Diagn 2009, 11: 482-487.
    • (2009) J Mol Diagn , vol.11 , pp. 482-487
    • Mattarucchi, E.1    Spinelli, O.2    Rambaldi, A.3    Pasquali, F.4    Lo Curto, F.5    Campiotti, L.6    Porta, G.7
  • 31
    • 30844457497 scopus 로고    scopus 로고
    • Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib.
    • Goldman J, Gordon M. Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter? Leuk Lymphoma 2006, 47: 1-7.
    • (2006) does it really matter? Leuk Lymphoma , vol.47 , pp. 1-7
    • Goldman, J.1    Gordon, M.2
  • 32
    • 84859415164 scopus 로고    scopus 로고
    • Minimal residual disease and discontinuation of therapy in chronic myeloid leukemia. can we aim at a cure?
    • Melo JV, Ross DM. Minimal residual disease and discontinuation of therapy in chronic myeloid leukemia: can we aim at a cure? Hematology Am Soc Hematol Educ Program 2011, 1: 136-142.
    • (2011) Hematology Am Soc Hematol Educ Program , vol.1 , pp. 136-142
    • Melo, J.V.1    Ross, D.M.2
  • 36
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, Holyoake TL. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002, 99: 319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6    Holyoake, T.L.7
  • 37
    • 33845664398 scopus 로고    scopus 로고
    • Primitive, quiescent and difficult to kill: the role of nonproliferating stem cells in chronic myeloid leukemia
    • Primitive, quiescent and difficult to kill: the role of nonproliferating stem cells in chronic myeloid leukemia. Cell cycle 2006, 5 (24): 2862-2866.
    • (2006) Cell cycle , vol.5 , Issue.24 , pp. 2862-2866
  • 39
    • 84887454814 scopus 로고    scopus 로고
    • Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation
    • Oct 24
    • Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T. Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell Death Dis. 2013 Oct 24;4: e879.
    • (2013) Cell Death Dis , vol.4
    • Tran, D.D.1    Saran, S.2    Dittrich-Breiholz, O.3    Williamson, A.J.4    Klebba-Färber, S.5    Koch, A.6    Kracht, M.7    Whetton, A.D.8    Tamura, T.9
  • 40
    • 84887468047 scopus 로고    scopus 로고
    • PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor
    • Airiau K, Mahon FX, Josselin M, Jeanneteau M, Belloc F. PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor. Cell Death Dis. 2013, 4: e827.
    • (2013) Cell Death Dis , vol.4
    • Airiau, K.1    Mahon, F.X.2    Josselin, M.3    Jeanneteau, M.4    Belloc, F.5
  • 41
    • 84879617626 scopus 로고    scopus 로고
    • Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells
    • Moraes VW, Caires AC, Paredes-Gamero EJ, Rodrigues T. Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells. Cell Death Dis. 2013, 4: e658.
    • (2013) Cell Death Dis , vol.4
    • Moraes, V.W.1    Caires, A.C.2    Paredes-Gamero, E.J.3    Rodrigues, T.4
  • 45
    • 78650949272 scopus 로고    scopus 로고
    • Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCRABL activity
    • Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW, Druker BJ. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCRABL activity. J Clin Invest 2011, 121: 396-409.
    • (2011) J Clin Invest , vol.121 , pp. 396-409
    • Corbin, A.S.1    Agarwal, A.2    Loriaux, M.3    Cortes, J.4    Deininger, M.W.5    Druker, B.J.6
  • 46
    • 77649162823 scopus 로고    scopus 로고
    • Why doesn't imatinib cure chronic myeloid leukemia?
    • Redner RL. Why doesn't imatinib cure chronic myeloid leukemia? The Oncologist 2010, 15: 182-186.
    • (2010) The Oncologist , vol.15 , pp. 182-186
    • Redner, R.L.1
  • 47
    • 33749524667 scopus 로고    scopus 로고
    • Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
    • Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M. Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nature Medicine 2006, 10: 1181-1184.
    • (2006) Nature Medicine , vol.10 , pp. 1181-1184
    • Roeder, I.1    Horn, M.2    Glauche, I.3    Hochhaus, A.4    Mueller, M.C.5    Loeffler, M.6
  • 48
    • 84898862592 scopus 로고    scopus 로고
    • Cumulative clinical experience from a decade of use: imatinib as first-line treatment of chronic myeloid leukemia
    • BaranY, Saydam G. Cumulative clinical experience from a decade of use: imatinib as first-line treatment of chronic myeloid leukemia. J Blood Med 2012, 3: 139-140.
    • (2012) J Blood Med , vol.3 , pp. 139-140
    • Baran, Y.1    Saydam, G.2
  • 49
    • 84887468047 scopus 로고    scopus 로고
    • PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor
    • Oct 3
    • Airiau K, Mahon FX, Josselin M, Jeanneteau M, Belloc F. PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor. Cell Death Dis. 2013 Oct 3;4: e827.
    • (2013) Cell Death Dis , vol.4
    • Airiau, K.1    Mahon, F.X.2    Josselin, M.3    Jeanneteau, M.4    Belloc, F.5
  • 50
    • 84879614859 scopus 로고    scopus 로고
    • B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1
    • Zhou H, Ma H, Wei W, Ji D, Song X, Sun J, Zhang J, Jia L. B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1. Cell Death Dis. 2013, 4: e654.
    • (2013) Cell Death Dis , vol.4
    • Zhou, H.1    Ma, H.2    Wei, W.3    Ji, D.4    Song, X.5    Sun, J.6    Zhang, J.7    Jia, L.8
  • 52
    • 44449085896 scopus 로고    scopus 로고
    • Linking miRNA regulation to BCR-ABL expression: the next dimension
    • Faber J, Gregory RI, Armstrong SA. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell 2008, 13: 467-469.
    • (2008) Cancer Cell , vol.13 , pp. 467-469
    • Faber, J.1    Gregory, R.I.2    Armstrong, S.A.3
  • 55
    • 84880267043 scopus 로고    scopus 로고
    • The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/-mice
    • Jul
    • Biswas S, Shi Q, Wernick A, Aiello A, Zinkel SS. The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/-mice. Cell Death Differ. 2013 Jul;20(7): 869-77
    • (2013) Cell Death Differ , vol.20 , Issue.7 , pp. 869-877
    • Biswas, S.1    Shi, Q.2    Wernick, A.3    Aiello, A.4    Zinkel, S.S.5
  • 60
    • 84901218392 scopus 로고    scopus 로고
    • The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway
    • Eldeeb MA, Fahlman RP. The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway. Oncotarget. 2014, 5(9): 2714-22.
    • (2014) Oncotarget , vol.5 , Issue.9 , pp. 2714-2722
    • Eldeeb, M.A.1    Fahlman, R.P.2
  • 61
    • 84891904194 scopus 로고    scopus 로고
    • Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
    • Martinez Marignac VL, Smith S, Toban N, Bazile M, Aloyz R Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming. Oncotarget. 2013, 4(12): 2550-66.
    • (2013) Oncotarget , vol.4 , Issue.12 , pp. 2550-2566
    • Martinez Marignac, V.L.1    Smith, S.2    Toban, N.3    Bazile, M.4    Aloyz, R.5
  • 63
    • 84880306032 scopus 로고    scopus 로고
    • Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations
    • Gerber JM, Gucwa JL, Esopi D, Gurel M, Haffner MC, Vala M, Nelson WG, Jones RJ, Yegnasubramanian S. Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations. Oncotarget. 2013;4(5): 715-28.5.
    • (2013) Oncotarget , vol.4 , Issue.5 , pp. 715-728
    • Gerber, J.M.1    Gucwa, J.L.2    Esopi, D.3    Gurel, M.4    Haffner, M.C.5    Vala, M.6    Nelson, W.G.7    Jones, R.J.8    Yegnasubramanian, S.9
  • 68
    • 84867309299 scopus 로고    scopus 로고
    • A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells
    • Smith PG, Tanaka H, Chantry A. A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells. Oncotarget. 2012, 3(5): 518-24.
    • (2012) Oncotarget , vol.3 , Issue.5 , pp. 518-524
    • Smith, P.G.1    Tanaka, H.2    Chantry, A.3
  • 71
    • 0038040665 scopus 로고    scopus 로고
    • Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principle, approaches, and laboratory aspects
    • Van der Velden VHJ, Hochhaus A, Cazzaniga G, Szczepanski T, Gabert J, van Dongen JJM. Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principle, approaches, and laboratory aspects. Leukemia 2003, 17: 1013-1034.
    • (2003) Leukemia , vol.17 , pp. 1013-1034
    • Van der Velden, V.H.J.1    Hochhaus, A.2    Cazzaniga, G.3    Szczepanski, T.4    Gabert, J.5    van Dongen, J.J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.