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Volumn 37, Issue 11, 2012, Pages 640-648

Implementation of management guidelines for chronic myeloidl leukemia perspectives in the United States

Author keywords

Chronic myeloid leukemia; Clinical practice guidelines; Dasatinib; Imatinib; Nilotinib; Tyrosine kinase inhibitors

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 84870697761     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (10)

References (62)
  • 1
    • 58149398623 scopus 로고    scopus 로고
    • Translation of the Philadelphia chromosome into therapy for CML
    • Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008;112(13):4808-4817.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4808-4817
    • Druker, B.J.1
  • 2
    • 68549125412 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia, BCR-ABL1+
    • Vardiman JW. Chronic myelogenous leukemia, BCR-ABL1+. Am J Clin Pathol 2009;132(2):250-260.
    • (2009) Am J Clin Pathol , vol.132 , Issue.2 , pp. 250-260
    • Vardiman, J.W.1
  • 4
    • 84870690891 scopus 로고    scopus 로고
    • Resource utilization and perceptions of major molecular response in chronic myeloid leukemia (CML): Results of a Delphi panel study (Abstract)
    • Quintas-Cardama A, Flamm M, Lill M, et al. Resource utilization and perceptions of major molecular response in chronic myeloid leukemia (CML): Results of a Delphi panel study (Abstract). Value Health 2011;14(3):A157.
    • (2011) Value Health , vol.14 , Issue.3
    • Quintas-Cardama, A.1    Flamm, M.2    Lill, M.3
  • 5
    • 84870707269 scopus 로고    scopus 로고
    • Survey of the frontline treatment and management of chronic myeloid leukemia (CML) in a real-word setting: Third annual update of the Worldwide Observational Registry Collecting Longitudinal Data on Management of Chronic Myeloid Leukemia Patients (the WORLD CML Registry)
    • San Diego, December 10, Available at, Accessed June 14, 2012
    • Pasquini R, Cortes JE, Kantarjian HM, et al. Survey of the frontline treatment and management of chronic myeloid leukemia (CML) in a real-word setting: Third annual update of the Worldwide Observational Registry Collecting Longitudinal Data on Management of Chronic Myeloid Leukemia Patients (the WORLD CML Registry). Presented at the American Society of Hematology annual meeting, San Diego, December 10, 2011. Available at: https://ash.confex.com/ash/2011/webprogram/Paper40024.html. Accessed June 14, 2012.
    • (2011) Presented At the American Society of Hematology Annual Meeting
    • Pasquini, R.1    Cortes, J.E.2    Kantarjian, H.M.3
  • 6
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355(23):2408-2417.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 7
    • 36348968931 scopus 로고    scopus 로고
    • Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
    • Kantarjian HM, Giles F, Gattermann N, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007;110(10):3540-3546.
    • (2007) Blood , vol.110 , Issue.10 , pp. 3540-3546
    • Kantarjian, H.M.1    Giles, F.2    Gattermann, N.3
  • 8
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H, Shah NP, Hochhaus A, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010;362(24):2260-2270.
    • (2010) N Engl J Med , vol.362 , Issue.24 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3
  • 9
    • 34249074686 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized phase 2 trial
    • Kantarjian H, Pasquini R, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized phase 2 trial. Blood 2007;109(12):5143-5150.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5143-5150
    • Kantarjian, H.1    Pasquini, R.2    Hamerschlak, N.3
  • 10
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronicphase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronicphase chronic myeloid leukemia. N Engl J Med 2003;348(11):994-1004.
    • (2003) N Engl J Med , vol.348 , Issue.11 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 11
    • 77953691179 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
    • Saglio G, Kim D-W, Issaragrisil S, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010;362(24):2251-2259.
    • (2010) N Engl J Med , vol.362 , Issue.24 , pp. 2251-2259
    • Saglio, G.1    Kim, D.-W.2    Issaragrisil, S.3
  • 12
    • 71849109054 scopus 로고    scopus 로고
    • Response definitions and European LeukemiaNet management recommendations
    • Baccarani M, Castagnetti F, Gugliotta G, et al. Response definitions and European LeukemiaNet management recommendations. Best Pract Res Clin Haematol 2009;22(3):331-341.
    • (2009) Best Pract Res Clin Haematol , vol.22 , Issue.3 , pp. 331-341
    • Baccarani, M.1    Castagnetti, F.2    Gugliotta, G.3
  • 13
    • 37549072095 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network, Version 2, Available at, Accessed July 5, 2011
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Chronic Myelogenous Leukemia. Version 2.2012. Available at: www.nccn.org/professionals/physician_gls/PDF/cml.pdf. Accessed July 5, 2011.
    • (2012) NCCN Clinical Practice Guidelines In Oncology. Chronic Myelogenous Leukemia
  • 14
    • 84870677852 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network, Available at, Accessed March 22
    • National Comprehensive Cancer Network. About NCCN. Available at: www.nccn.org/about/default.asp. Accessed March 22, 2011.
    • (2011) About NCCN
  • 15
    • 84870700116 scopus 로고    scopus 로고
    • European LeukemiaNet. Available at, Accessed March 22
    • European LeukemiaNet. Available at: www.leukemia-net.org/content/home. Accessed March 22 2011.
    • (2011)
  • 16
    • 0036939303 scopus 로고    scopus 로고
    • High reliability and sensitivity of the BCR/ABL1 D-FISH test for the detection of BCR/ABL rearrangements
    • Pelz AF, Kroning H, Franke A, et al. High reliability and sensitivity of the BCR/ABL1 D-FISH test for the detection of BCR/ABL rearrangements. Ann Hematol 2002;81(3):147-153.
    • (2002) Ann Hematol , vol.81 , Issue.3 , pp. 147-153
    • Pelz, A.F.1    Kroning, H.2    Franke, A.3
  • 17
    • 85009854501 scopus 로고    scopus 로고
    • Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: A study on 350 cases
    • Schoch C, Schnittger S, Bursch S, et al. Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: A study on 350 cases. Leukemia 2002;16(1):53-59.
    • (2002) Leukemia , vol.16 , Issue.1 , pp. 53-59
    • Schoch, C.1    Schnittger, S.2    Bursch, S.3
  • 18
    • 0022623818 scopus 로고
    • Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia
    • Talpaz M, Kantarjian HM, McCredie K, et al. Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. N Engl J Med 1986;314(17):1065-1069.
    • (1986) N Engl J Med , vol.314 , Issue.17 , pp. 1065-1069
    • Talpaz, M.1    Kantarjian, H.M.2    McCredie, K.3
  • 19
    • 0029041749 scopus 로고
    • UK Medical Research Council randomised, multicentre trial of interferon-alpha n1 for chronic myeloid leukaemia: Improved survival irrespective of cytogenetic response
    • Allan NC, Richards SM, Shepherd PC. UK Medical Research Council randomised, multicentre trial of interferon-alpha n1 for chronic myeloid leukaemia: Improved survival irrespective of cytogenetic response. Lancet 1995;345(8962):1392-1397.
    • (1995) Lancet , vol.345 , Issue.8962 , pp. 1392-1397
    • Allan, N.C.1    Richards, S.M.2    Shepherd, P.C.3
  • 20
    • 23444462074 scopus 로고
    • Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia
    • Italian Cooperative Study Group on Chronic Myeloid Leukemia
    • Italian Cooperative Study Group on Chronic Myeloid Leukemia. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med 1994;330(12):820-825.
    • (1994) N Engl J Med , vol.330 , Issue.12 , pp. 820-825
  • 21
    • 0034951384 scopus 로고    scopus 로고
    • STI571: Targeting BCR-ABL as therapy for CML
    • Mauro MJ, Druker BJ. STI571: Targeting BCR-ABL as therapy for CML. Oncologist 2001;6(3):233-238.
    • (2001) Oncologist , vol.6 , Issue.3 , pp. 233-238
    • Mauro, M.J.1    Druker, B.J.2
  • 22
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003;349(15):1423-1432.
    • (2003) N Engl J Med , vol.349 , Issue.15 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 23
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005;65(11):4500-4505.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 24
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005;7(2):129-141.
    • (2005) Cancer Cell , vol.7 , Issue.2 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 25
    • 80052383499 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
    • Kantarjian HM, Hochhaus A, Saglio G, et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011;12(9):841-851.
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 841-851
    • Kantarjian, H.M.1    Hochhaus, A.2    Saglio, G.3
  • 26
    • 79952038063 scopus 로고    scopus 로고
    • ENESTnd update: Continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) (Abstract)
    • Hughes TP, Hochhaus A, Saglio G, et al. ENESTnd update: Continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) (Abstract). Blood 2010;116(21):207.
    • (2010) Blood , vol.116 , Issue.21 , pp. 207
    • Hughes, T.P.1    Hochhaus, A.2    Saglio, G.3
  • 27
    • 81555217734 scopus 로고    scopus 로고
    • Comparison of nilotinib and imatinib in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 24-month followup (Abstract)
    • Larson RA, Kim D, Rosti G, et al. Comparison of nilotinib and imatinib in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 24-month followup (Abstract). J Clin Oncol 2011;29:6511.
    • (2011) J Clin Oncol , vol.29 , pp. 6511
    • Larson, R.A.1    Kim, D.2    Rosti, G.3
  • 28
    • 84861696317 scopus 로고    scopus 로고
    • Nilotinib versus imatinib in patients (pts) with newly diagnosed Philadelphia chromosome- positive (Ph+) chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 36-month (mo) follow-up (Abstract)
    • Saglio G, LeCoutre PD, Pasquini R, et al. Nilotinib versus imatinib in patients (pts) with newly diagnosed Philadelphia chromosome- positive (Ph+) chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 36-month (mo) follow-up (Abstract). Blood 2011;118(21):452.
    • (2011) Blood , vol.118 , Issue.21 , pp. 452
    • Saglio, G.1    Lecoutre, P.D.2    Pasquini, R.3
  • 29
    • 79952038795 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) in the DASISION trial: 18-month follow-up (Abstract)
    • Shah N, Kantarjian H, Hochhaus A, et al. Dasatinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) in the DASISION trial: 18-month follow-up (Abstract). Blood 2010;116(21):206.
    • (2010) Blood , vol.116 , Issue.21 , pp. 206
    • Shah, N.1    Kantarjian, H.2    Hochhaus, A.3
  • 30
    • 84863011486 scopus 로고    scopus 로고
    • Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)
    • Kantarjian HM, Shah NP, Cortes JE, et al. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood 2012;119(5):1123-1129.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1123-1129
    • Kantarjian, H.M.1    Shah, N.P.2    Cortes, J.E.3
  • 31
    • 76549116248 scopus 로고    scopus 로고
    • Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response, or intolerance to imatinib
    • Shah NP, Kim D-W, Kantarjian H, et al. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response, or intolerance to imatinib. Haematologica 2010;95(2):232-240.
    • (2010) Haematologica , vol.95 , Issue.2 , pp. 232-240
    • Shah, N.P.1    Kim, D.-W.2    Kantarjian, H.3
  • 32
    • 79251546724 scopus 로고    scopus 로고
    • Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results
    • Kantarjian HM, Giles FJ, Bhalla KN, et al. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results. Blood 2011;117(4):1141-1145.
    • (2011) Blood , vol.117 , Issue.4 , pp. 1141-1145
    • Kantarjian, H.M.1    Giles, F.J.2    Bhalla, K.N.3
  • 33
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • Hochhaus A, Kantarjian HM, Baccarani M, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007;109(6):2303-2309.
    • (2007) Blood , vol.109 , Issue.6 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3
  • 34
    • 80051573352 scopus 로고    scopus 로고
    • BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Recommendations from an expert panel on behalf of European LeukemiaNet
    • Soverini S, Hochhaus A, Nicolini FE, et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Recommendations from an expert panel on behalf of European LeukemiaNet. Blood 2011;118(5):1208-1215.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1208-1215
    • Soverini, S.1    Hochhaus, A.2    Nicolini, F.E.3
  • 35
    • 84865182397 scopus 로고    scopus 로고
    • Validation of the new European LeukemiaNet (ELN) recommendations for Bcr-Abl kinase domain mutation analysis in chronic myeloid leukemia: An analysis of the GIMEMA CML Working Party studies (Abstract)
    • Soverini S, Gnani A, De Benedittis C, et al. Validation of the new European LeukemiaNet (ELN) recommendations for Bcr-Abl kinase domain mutation analysis in chronic myeloid leukemia: An analysis of the GIMEMA CML Working Party studies (Abstract). Blood 2011;118(21):112.
    • (2011) Blood , vol.118 , Issue.21 , pp. 112
    • Soverini, S.1    Gnani, A.2    de Benedittis, C.3
  • 36
    • 79955018499 scopus 로고    scopus 로고
    • Tolerabilityadapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-a in newly diagnosed chronic myeloid leukemia
    • Hehlmann R, Lauseker M, Jung-Munkwitz S, et al. Tolerabilityadapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-a in newly diagnosed chronic myeloid leukemia. J Clin Oncol 2011;29(12):1634-1642.
    • (2011) J Clin Oncol , vol.29 , Issue.12 , pp. 1634-1642
    • Hehlmann, R.1    Lauseker, M.2    Jung-Munkwitz, S.3
  • 37
    • 77958595179 scopus 로고    scopus 로고
    • Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the international randomized study of interferon versus STI571 (IRIS)
    • Hughes TP, Hochhaus A, Branford S, et al. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the international randomized study of interferon versus STI571 (IRIS). Blood 2010;116(19):3758-3765.
    • (2010) Blood , vol.116 , Issue.19 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3
  • 38
    • 79958839899 scopus 로고    scopus 로고
    • Molecular response<1% BCR-ABL IS at 12 months is associated with improved overall and progression-free survival: The randomized German CML Study IV (Abstract)
    • Müller MC, Hochhaus A, Lauseker M, et al. Molecular response<1% BCR-ABL IS at 12 months is associated with improved overall and progression-free survival: The randomized German CML Study IV (Abstract). Blood 2010;116(21):669.
    • (2010) Blood , vol.116 , Issue.21 , pp. 669
    • Müller, M.C.1    Hochhaus, A.2    Lauseker, M.3
  • 39
    • 67049087117 scopus 로고    scopus 로고
    • Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study
    • Noens L, van Lierde MA, De Bock R, et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study. Blood 2009;113(22):5401-5411.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5401-5411
    • Noens, L.1    van Lierde, M.A.2    de Bock, R.3
  • 40
    • 77952467377 scopus 로고    scopus 로고
    • Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
    • Marin D, Bazeos A, Mahon FX, et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010;28(14):2381-2388.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2381-2388
    • Marin, D.1    Bazeos, A.2    Mahon, F.X.3
  • 41
    • 79953823237 scopus 로고    scopus 로고
    • Poor adherence is the main reason for loss of CCyR and imatinib failure for CML patients on long term therapy
    • Ibrahim AR, Eliasson L, Apperley JF, et al. Poor adherence is the main reason for loss of CCyR and imatinib failure for CML patients on long term therapy. Blood 2011;117(14):3733-3376.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3733-3776
    • Ibrahim, A.R.1    Eliasson, L.2    Apperley, J.F.3
  • 42
    • 34249782019 scopus 로고    scopus 로고
    • Treatment interruptions and non-adherence with imatinib and associated healthcare costs: A retrospective analysis among managed care patients with chronic myelogenous leukaemia
    • Darkow T, Henk HJ, Thomas SK, et al. Treatment interruptions and non-adherence with imatinib and associated healthcare costs: A retrospective analysis among managed care patients with chronic myelogenous leukaemia. Pharmacoeconomics 2007;25(6):481-496.
    • (2007) Pharmacoeconomics , vol.25 , Issue.6 , pp. 481-496
    • Darkow, T.1    Henk, H.J.2    Thomas, S.K.3
  • 43
    • 77649221871 scopus 로고    scopus 로고
    • Healthcare resource utilization and costs associated with non-adherence to imatinib treatment in chronic myeloid leukemia patients
    • Wu EQ, Johnson S, Beaulieu N, et al. Healthcare resource utilization and costs associated with non-adherence to imatinib treatment in chronic myeloid leukemia patients. Curr Med Res Opin 2010;26(1):61-69.
    • (2010) Curr Med Res Opin , vol.26 , Issue.1 , pp. 61-69
    • Wu, E.Q.1    Johnson, S.2    Beaulieu, N.3
  • 44
    • 77958577395 scopus 로고    scopus 로고
    • Comprehensive evaluation of time-to-response parameter as a predictor of treatment failure following imatinib therapy in chronic phase chronic myeloid leukemia: Which parameter at which time-point does matter?
    • Kim DH, Sriharsha L, Jung CW, et al. Comprehensive evaluation of time-to-response parameter as a predictor of treatment failure following imatinib therapy in chronic phase chronic myeloid leukemia: Which parameter at which time-point does matter? Am JHematol 2010;85(11):856-862.
    • (2010) Am JHematol , vol.85 , Issue.11 , pp. 856-862
    • Kim, D.H.1    Sriharsha, L.2    Jung, C.W.3
  • 45
    • 84865864744 scopus 로고    scopus 로고
    • Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML)
    • Hanfstein B, Muller MC, Hehlmann R, et al. Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML). Leukemia 2012;26(9):2096-2102.
    • (2012) Leukemia , vol.26 , Issue.9 , pp. 2096-2102
    • Hanfstein, B.1    Muller, M.C.2    Hehlmann, R.3
  • 46
    • 84862907694 scopus 로고    scopus 로고
    • Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
    • Marin D, Ibrahim AR, Lucas C, et al. Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. J Clin Oncol 2012;30(3):232-238.
    • (2012) J Clin Oncol , vol.30 , Issue.3 , pp. 232-238
    • Marin, D.1    Ibrahim, A.R.2    Lucas, C.3
  • 47
    • 84859857734 scopus 로고    scopus 로고
    • Dasatinib and imatinibinduced reductions in BCR-ABL transcript levels below 10% at 3 months are associated with improved responses in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): Analysis of molecular response kinetics in the DASISION trial (Abstract)
    • Hochhaus A, Saglio G, Chuah C, et al. Dasatinib and imatinibinduced reductions in BCR-ABL transcript levels below 10% at 3 months are associated with improved responses in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): Analysis of molecular response kinetics in the DASISION trial (Abstract). Blood 2011;118(21):2767.
    • (2011) Blood , vol.118 , Issue.21
    • Hochhaus, A.1    Saglio, G.2    Chuah, C.3
  • 48
    • 84867887143 scopus 로고    scopus 로고
    • Complete cytogenetic response after 3 months is a very early indicator of good response to imatinib as first-line treatment in chronic myelogenous leukemia (Abstract)
    • Latagliata R, Breccia M, Carmosino I, et al. Complete cytogenetic response after 3 months is a very early indicator of good response to imatinib as first-line treatment in chronic myelogenous leukemia (Abstract). Blood 2011;118(21):3783.
    • (2011) Blood , vol.118 , Issue.21 , pp. 3783
    • Latagliata, R.1    Breccia, M.2    Carmosino, I.3
  • 49
    • 84870719087 scopus 로고    scopus 로고
    • Landmark analysis of imatinib treatment in CML chronic phase: ES-FISH <10% Ph+ at 3 months associated with better cytogenetic response and improved long-term event-free survival (Abstract)
    • Ohm A-C, Barbany G, Arvidsson I, et al. Landmark analysis of imatinib treatment in CML chronic phase: ES-FISH <10% Ph+ at 3 months associated with better cytogenetic response and improved long-term event-free survival (Abstract). Blood 2011;118(21):1702.
    • (2011) Blood , vol.118 , Issue.21 , pp. 1702
    • Ohm, A.-C.1    Barbany, G.2    Arvidsson, I.3
  • 50
    • 77958012952 scopus 로고    scopus 로고
    • Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR
    • Ross DM, Branford S, Seymour JF, et al. Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR. Leukemia 2010;24(10):1719-1724.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1719-1724
    • Ross, D.M.1    Branford, S.2    Seymour, J.F.3
  • 51
    • 79955066374 scopus 로고    scopus 로고
    • Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay
    • Goh HG, Lin M, Fukushima T, et al. Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay. Leuk Lymphoma 2011;52(5):896-904.
    • (2011) Leuk Lymphoma , vol.52 , Issue.5 , pp. 896-904
    • Goh, H.G.1    Lin, M.2    Fukushima, T.3
  • 52
    • 78049528573 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial
    • Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol 2010;11(11):1029-1035.
    • (2010) Lancet Oncol , vol.11 , Issue.11 , pp. 1029-1035
    • Mahon, F.X.1    Rea, D.2    Guilhot, J.3
  • 53
    • 84860834532 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukemia who have maintained complete molecular response: Updated results of the STIM study (Abstract)
    • Mahon F-X, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukemia who have maintained complete molecular response: Updated results of the STIM study (Abstract). Blood 2011;118(21):603.
    • (2011) Blood , vol.118 , Issue.21 , pp. 603
    • Mahon, F.-X.1    Rea, D.2    Guilhot, J.3
  • 54
    • 84860840888 scopus 로고    scopus 로고
    • Discontinuation of dasatinib or nilotinib in chronic myeloid leukemia (CML) patients (pts) with stable undetectable Bcr-Abl transcripts: Results from the French CML Group (FILMC) (Abstract)
    • Rea D, Rousselot P, Nicolini FE, et al. Discontinuation of dasatinib or nilotinib in chronic myeloid leukemia (CML) patients (pts) with stable undetectable Bcr-Abl transcripts: Results from the French CML Group (FILMC) (Abstract). Blood 2011;118(21):604.
    • (2011) Blood , vol.118 , Issue.21 , pp. 604
    • Rea, D.1    Rousselot, P.2    Nicolini, F.E.3
  • 55
    • 84860729243 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy in chronic myeloid leukemia patients with sustained complete molecular response4.5 (CMR4.5) (Abstract)
    • Goh H-G, Choi S-Y, Bang J-H, et al. Discontinuation of imatinib therapy in chronic myeloid leukemia patients with sustained complete molecular response4.5 (CMR4.5) (Abstract). Blood 2011; 118(21):2763.
    • (2011) Blood , vol.118 , Issue.21 , pp. 2763
    • Goh, H.-G.1    Choi, S.-Y.2    Bang, J.-H.3
  • 56
    • 84870657908 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with CML and sustained complete molecular response (CMR) for over 2 years in the Japanese population: An interim analysis of KEIO STIM study (Abstract)
    • Matsuki E, Ono Y, Sakurai M, et al. Discontinuation of imatinib in patients with CML and sustained complete molecular response (CMR) for over 2 years in the Japanese population: An interim analysis of KEIO STIM study (Abstract). Blood 2011;118(21):3765.
    • (2011) Blood , vol.118 , Issue.21 , pp. 3765
    • Matsuki, E.1    Ono, Y.2    Sakurai, M.3
  • 57
    • 84870708875 scopus 로고    scopus 로고
    • Fluctuating values of molecular residual disease (MRD) without molecular progression after imatinib discontinuation in patients (pts) with chronic myeloid leukemia (CML) who have maintained complete molecular response: Implications for re-treatment criteria and role of prior interferon therapy: A pilot study of the French CML Group (FILMC) (Abstract)
    • Rousselot P, Makhoul PC, Rea D, et al. Fluctuating values of molecular residual disease (MRD) without molecular progression after imatinib discontinuation in patients (pts) with chronic myeloid leukemia (CML) who have maintained complete molecular response: Implications for re-treatment criteria and role of prior interferon therapy: A pilot study of the French CML Group (FILMC) (Abstract). Blood 2011;118(21):3781.
    • (2011) Blood , vol.118 , Issue.21 , pp. 3781
    • Rousselot, P.1    Makhoul, P.C.2    Rea, D.3
  • 58
    • 84870674620 scopus 로고    scopus 로고
    • Discontinuation of imatinib in Japanese patients with chronic myeloid leukemia (Abstract)
    • Takahashi N, Kyo T, Maeda Y, et al. Discontinuation of imatinib in Japanese patients with chronic myeloid leukemia (Abstract). Blood 2011;118(21):3759.
    • (2011) Blood , vol.118 , Issue.21 , pp. 3759
    • Takahashi, N.1    Kyo, T.2    Maeda, Y.3
  • 59
    • 66749112820 scopus 로고    scopus 로고
    • Role of NCCN in integrating cancer clinical practice guidelines into the healthcare debate
    • Benson AB, Brown E. Role of NCCN in integrating cancer clinical practice guidelines into the healthcare debate. Am Health Drug Benefits 2008;1(1):28-33.
    • (2008) Am Health Drug Benefits , vol.1 , Issue.1 , pp. 28-33
    • Benson, A.B.1    Brown, E.2
  • 60
    • 82955193752 scopus 로고    scopus 로고
    • Cost-effectiveness of dasatinib and nilotinib for imatinib-resistant or -intolerant chronic phase chronic myeloid leukemia
    • Hoyle M, Rogers G, Moxham T, et al. Cost-effectiveness of dasatinib and nilotinib for imatinib-resistant or -intolerant chronic phase chronic myeloid leukemia. Value Health 2011;14(8):1057-1067.
    • (2011) Value Health , vol.14 , Issue.8 , pp. 1057-1067
    • Hoyle, M.1    Rogers, G.2    Moxham, T.3
  • 61
    • 78349255323 scopus 로고    scopus 로고
    • Retrospective real-world comparison of medical visits, costs, and adherence between nilotinib and dasatinib in chronic myeloid leukemia
    • Wu EQ, Guerin A, Yu AP, et al. Retrospective real-world comparison of medical visits, costs, and adherence between nilotinib and dasatinib in chronic myeloid leukemia. Curr Med Res Opin 2010;26(12):2861-2869.
    • (2010) Curr Med Res Opin , vol.26 , Issue.12 , pp. 2861-2869
    • Wu, E.Q.1    Guerin, A.2    Yu, A.P.3
  • 62
    • 77953373231 scopus 로고    scopus 로고
    • The burden of managing pleural effusions in patients with chronic myelogenous leukemia post-imatinib failure: A literature-based economic analysis
    • Stephens J, Carpiuc KT, Botteman M. The burden of managing pleural effusions in patients with chronic myelogenous leukemia post-imatinib failure: A literature-based economic analysis. Int J Gen Med 2010;3:31-36.
    • (2010) Int J Gen Med , vol.3 , pp. 31-36
    • Stephens, J.1    Carpiuc, K.T.2    Botteman, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.