The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2714-2722

  Eldeeb, Mohamed A ^a,b   Fahlman, Richard P ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Lyn; N end rule; Protein degradation; Ubiquitination; UBR

Indexed keywords

IMATINIB; LEUCINE; PROTEIN KINASE LYN; UBIQUITIN PROTEIN LIGASE E3; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CASPASE; LYN PROTEIN-TYROSINE KINASE; PIPERAZINE DERIVATIVE; PROTEASOME; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GENE SILENCING; LEUKEMIA CELL LINE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; GENETICS; HUMAN; METABOLISM; SITE DIRECTED MUTAGENESIS; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZAMIDES; BLOTTING, WESTERN; CASPASES; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MUTAGENESIS, SITE-DIRECTED; PIPERAZINES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; PYRIMIDINES; RNA, SMALL INTERFERING; SRC-FAMILY KINASES; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASES;

EID: 84901218392     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1931     Document Type: Article

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