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Volumn 4, Issue 6, 2013, Pages

B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1

Author keywords

B4GALT family; hedgehog signaling; human leukemia cell line; multidrug resistance; multidrug resistance associated protein 1; P glycoprotein

Indexed keywords

BETA 1,4 GALACTOSYLTRANSFERASE 1; BETA 1,4 GALACTOSYLTRANSFERASE 5; CYCLOPAMINE; DOXORUBICIN; GALACTOSYLTRANSFERASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 84879614859     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.186     Document Type: Article
Times cited : (66)

References (43)
  • 1
    • 0037466315 scopus 로고    scopus 로고
    • An evolving hierarchical family classification for glycosyltransferases
    • Coutinho PM, Deleury E, Davies GJ, Henrissat B. An evolving hierarchical family classification for glycosyltransferases. J Mol Biol 2003; 328: 307-317.
    • (2003) J Mol Biol , vol.328 , pp. 307-317
    • Coutinho, P.M.1    Deleury, E.2    Davies, G.J.3    Henrissat, B.4
  • 2
    • 84862919698 scopus 로고    scopus 로고
    • Glycan-related gene expression signatures in human metastatic hepatocellular carcinoma cells
    • Kang X, Wang N, Pei C, Sun L, Sun R, Chen J et al. Glycan-related gene expression signatures in human metastatic hepatocellular carcinoma cells. Exp Ther Med 2012; 3: 415-422.
    • (2012) Exp Ther Med , vol.3 , pp. 415-422
    • Kang, X.1    Wang, N.2    Pei, C.3    Sun, L.4    Sun, R.5    Chen, J.6
  • 3
    • 78651273016 scopus 로고    scopus 로고
    • Glycan changes: Cancer metastasis and anti-cancer vaccines
    • Li M, Song L, Qin X. Glycan changes: cancer metastasis and anti-cancer vaccines. J Biosci 2010; 35: 665-673.
    • (2010) J Biosci , vol.35 , pp. 665-673
    • Li, M.1    Song, L.2    Qin, X.3
  • 4
    • 34249901538 scopus 로고    scopus 로고
    • N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma
    • Kudo T, Nakagawa H, Takahashi M, Hamaguchi J, Kamiyama N, Yokoo H et al. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. Mol Cancer 2007; 6: 32-40.
    • (2007) Mol Cancer , vol.6 , pp. 32-40
    • Kudo, T.1    Nakagawa, H.2    Takahashi, M.3    Hamaguchi, J.4    Kamiyama, N.5    Yokoo, H.6
  • 5
    • 80555136756 scopus 로고    scopus 로고
    • Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells
    • Nakano M, Saldanha R, Gö bel A, Kavallaris M, Packer NH. Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. Mol Cell Proteomics 2011; 10: M111.009001.
    • (2011) Mol Cell Proteomics , vol.10
    • Nakano, M.1    Saldanha, R.2    Gö Bel, A.3    Kavallaris, M.4    Packer, N.H.5
  • 6
    • 84861431411 scopus 로고    scopus 로고
    • Glycomic alterations are associated with multidrug resistance in human leukemia
    • Zhang Z, Zhao Y, Jiang L, Miao X, Zhou H, Jia L. Glycomic alterations are associated with multidrug resistance in human leukemia. Int J Biochem Cell Biol 2012; 44: 1244-1253.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1244-1253
    • Zhang, Z.1    Zhao, Y.2    Jiang, L.3    Miao, X.4    Zhou, H.5    Jia, L.6
  • 7
    • 0032759101 scopus 로고    scopus 로고
    • Identification and characterization of large galactosyltransferase gene families: Galactosyltransferases for all functions
    • Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta 1999; 1473: 35-53.
    • (1999) Biochim Biophys Acta , vol.1473 , pp. 35-53
    • Amado, M.1    Almeida, R.2    Schwientek, T.3    Clausen, H.4
  • 8
    • 77349124718 scopus 로고    scopus 로고
    • Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4\+ T cells
    • Han Y, Zhou X, Ji Y, Shen A, Sun X, Hu Y et al. Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4\+ T cells. Cell Immunol 2010; 262: 11-17.
    • (2010) Cell Immunol , vol.262 , pp. 11-17
    • Han, Y.1    Zhou, X.2    Ji, Y.3    Shen, A.4    Sun, X.5    Hu, Y.6
  • 10
    • 0035158267 scopus 로고    scopus 로고
    • Differential gene expression of beta-1,4-galactosyltransferases I, II and v during mouse brain development
    • Nakamura N, Yamakawa N, Sato T, Tojo H, Tachi C, Furukawa K. Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development. J Neurochem 2001; 76: 29-38.
    • (2001) J Neurochem , vol.76 , pp. 29-38
    • Nakamura, N.1    Yamakawa, N.2    Sato, T.3    Tojo, H.4    Tachi, C.5    Furukawa, K.6
  • 11
    • 2242472978 scopus 로고    scopus 로고
    • Identification of a drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
    • Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T et al. Identification of a Drosophila gene encoding xylosylprotein beta4- galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. J Biol Chem 2002; 277: 46280-46288.
    • (2002) J Biol Chem , vol.277 , pp. 46280-46288
    • Nakamura, Y.1    Haines, N.2    Chen, J.3    Okajima, T.4    Furukawa, K.5    Urano, T.6
  • 12
    • 20144389548 scopus 로고    scopus 로고
    • Elevated beta1,4-galactosyltransferase i in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator
    • Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z et al. Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. J Biol Chem 2005; 280: 12503-12516.
    • (2005) J Biol Chem , vol.280 , pp. 12503-12516
    • Zhu, X.1    Jiang, J.2    Shen, H.3    Wang, H.4    Zong, H.5    Li, Z.6
  • 13
    • 84867218421 scopus 로고    scopus 로고
    • Estrogen induced b-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells
    • Choi HJ, Chung TW, Kim CH, Jeong HS, Joo M, Youn B et al. Estrogen induced b-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells. Biochem Biophys Res Commun 2012; 426: 620-625.
    • (2012) Biochem Biophys Res Commun , vol.426 , pp. 620-625
    • Choi, H.J.1    Chung, T.W.2    Kim, C.H.3    Jeong, H.S.4    Joo, M.5    Youn, B.6
  • 14
    • 0035997973 scopus 로고    scopus 로고
    • Expression and characterization of beta-1,4-galactosyltransferase from Neisseria meningitidis and Neisseria gonorrhoeae
    • Park JE, Lee KY, Do SI, Lee SS. Expression and characterization of beta-1,4-galactosyltransferase from Neisseria meningitidis and Neisseria gonorrhoeae. J Biochem Mol Biol 2002; 35: 330-336.
    • (2002) J Biochem Mol Biol , vol.35 , pp. 330-336
    • Park, J.E.1    Lee, K.Y.2    Do, S.I.3    Lee, S.S.4
  • 15
    • 52549095339 scopus 로고    scopus 로고
    • The expression patterns of beta1,4 galactosyltransferase i and v mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury
    • Yan M, Cheng C, Ding F, Jiang J, Gao L, Xia C et al. The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury. Glycoconj J 2008; 25: 685-701.
    • (2008) Glycoconj J , vol.25 , pp. 685-701
    • Yan, M.1    Cheng, C.2    Ding, F.3    Jiang, J.4    Gao, L.5    Xia, C.6
  • 17
    • 55049089292 scopus 로고    scopus 로고
    • Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells
    • Wassler MJ, Shur BD, Zhou W, Geng YJ. Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Stem Cells 2008; 26: 2006-2018.
    • (2008) Stem Cells , vol.26 , pp. 2006-2018
    • Wassler, M.J.1    Shur, B.D.2    Zhou, W.3    Geng, Y.J.4
  • 18
    • 45949098700 scopus 로고    scopus 로고
    • Down-regulation of beta1,4GalT v at protein level contributes to arsenic trioxide-induced glioma cell apoptosis
    • Wei Y, Liu D, Ge Y, Zhou F, Xu J, Chen H et al. Down-regulation of beta1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis. Cancer Lett 2008; 267: 96-105.
    • (2008) Cancer Lett , vol.267 , pp. 96-105
    • Wei, Y.1    Liu, D.2    Ge, Y.3    Zhou, F.4    Xu, J.5    Chen, H.6
  • 19
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003; 3: 903-911.
    • (2003) Nat Rev Cancer , vol.3 , pp. 903-911
    • Pasca Di Magliano, M.1    Hebrok, M.2
  • 20
    • 79952387584 scopus 로고    scopus 로고
    • Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas
    • Zhu W, You Z, Li T, Yu C, Tao G, Hu M et al. Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas. Jpn J Clin Oncol 2011; 41: 386-393.
    • (2011) Jpn J Clin Oncol , vol.41 , pp. 386-393
    • Zhu, W.1    You, Z.2    Li, T.3    Yu, C.4    Tao, G.5    Hu, M.6
  • 21
    • 70949087325 scopus 로고    scopus 로고
    • Gli1 is a potential target for alleviating multidrug resistance of gliomas
    • Cui D, Xu Q, Wang K, Che X. Gli1 is a potential target for alleviating multidrug resistance of gliomas. J Neurol Sci 2010; 288: 156-166.
    • (2010) J Neurol Sci , vol.288 , pp. 156-166
    • Cui, D.1    Xu, Q.2    Wang, K.3    Che, X.4
  • 22
    • 65349188910 scopus 로고    scopus 로고
    • Drug resistance is dramatically restored by hedgehog inhibitors in CD34\+ leukemia cells
    • Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S et al. Drug resistance is dramatically restored by hedgehog inhibitors in CD34\+ leukemia cells. Cancer Sci 2009; 100: 948-955.
    • (2009) Cancer Sci , vol.100 , pp. 948-955
    • Kobune, M.1    Takimoto, R.2    Murase, K.3    Iyama, S.4    Sato, T.5    Kikuchi, S.6
  • 23
    • 58549088199 scopus 로고    scopus 로고
    • Drug-drug Interactions mediated through p-glycoprotein: Clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug
    • Fenner KS, Troutman MD, Kempshall S, Cook JA, Ware JA, Smith DA et al. Drug-drug Interactions mediated through p-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug. Clin Pharmacol Ther 2009; 85: 173-181.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 173-181
    • Fenner, K.S.1    Troutman, M.D.2    Kempshall, S.3    Cook, J.A.4    Ware, J.A.5    Smith, D.A.6
  • 24
    • 33745835398 scopus 로고    scopus 로고
    • Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    • Deeley RG, Westlake C, Cole SP. Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006; 86: 849-899.
    • (2006) Physiol Rev , vol.86 , pp. 849-899
    • Deeley, R.G.1    Westlake, C.2    Cole, S.P.3
  • 25
    • 84867796359 scopus 로고    scopus 로고
    • B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line
    • Zhou H, Zhang Z, Liu C, Jin C, Zhang J, Miao X et al. B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line. IUBMB Life 2012; 64: 889-900.
    • (2012) IUBMB Life , vol.64 , pp. 889-900
    • Zhou, H.1    Zhang, Z.2    Liu, C.3    Jin, C.4    Zhang, J.5    Miao, X.6
  • 26
    • 84867233080 scopus 로고    scopus 로고
    • Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancerspecific biomarker of colorectal tumors
    • Poeta ML, Massi E, Parrella P, Pellegrini P, De Robertis M, Copetti M et al. Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancerspecific biomarker of colorectal tumors. Genes Chromosomes Cancer 2012; 51: 1133-1143.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 1133-1143
    • Poeta, M.L.1    Massi, E.2    Parrella, P.3    Pellegrini, P.4    De Robertis, M.5    Copetti, M.6
  • 27
    • 64149106273 scopus 로고    scopus 로고
    • Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectinmediated tumor metastasis
    • Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK et al. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4- galactosyltransferase 1 and selectinmediated tumor metastasis. J Biol Chem 2009; 284: 4952-4959.
    • (2009) J Biol Chem , vol.284 , pp. 4952-4959
    • Brown, J.R.1    Yang, F.2    Sinha, A.3    Ramakrishnan, B.4    Tor, Y.5    Qasba, P.K.6
  • 28
    • 41349113352 scopus 로고    scopus 로고
    • Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis
    • Zhou J, Wei Y, Liu D, Ge X, Zhou F, Jiang XY et al. Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis. J Biochem 2008; 143: 547-554.
    • (2008) J Biochem , vol.143 , pp. 547-554
    • Zhou, J.1    Wei, Y.2    Liu, D.3    Ge, X.4    Zhou, F.5    Jiang, X.Y.6
  • 29
    • 29344454268 scopus 로고    scopus 로고
    • Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis
    • Chen WS, Chang HY, Li CP, Liu JM, Huang TS. Tumor beta-1,4- galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis. Clin Cancer Res 2005; 11: 8615-8622.
    • (2005) Clin Cancer Res , vol.11 , pp. 8615-8622
    • Chen, W.S.1    Chang, H.Y.2    Li, C.P.3    Liu, J.M.4    Huang, T.S.5
  • 30
    • 0036738679 scopus 로고    scopus 로고
    • Over-expression of beta-1,4-galactosyltransferase v increases the growth of astrocytoma cell line
    • Xu S, Zhang S, Chen C, Yan J, Cai M, Zhu X et al. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line. J Exp Clin Cancer Res 2002; 21: 409-414.
    • (2002) J Exp Clin Cancer Res , vol.21 , pp. 409-414
    • Xu, S.1    Zhang, S.2    Chen, C.3    Yan, J.4    Cai, M.5    Zhu, X.6
  • 31
    • 77953232420 scopus 로고    scopus 로고
    • Beta1,4-galactosyltransferase v regulates self-renewal of glioma-initiating cell
    • Wei Y, Zhou F, Ge Y, Chen H, Cui C, Li Q et al. Beta1,4- galactosyltransferase V regulates self-renewal of glioma-initiating cell. Biochem Biophys Res Commun 2010; 396: 602-607.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 602-607
    • Wei, Y.1    Zhou, F.2    Ge, Y.3    Chen, H.4    Cui, C.5    Li, Q.6
  • 32
    • 78549282816 scopus 로고    scopus 로고
    • Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: A major enzyme in the glycosaminoglycan synthesis pathway
    • Talhaoui I, Bui C, Oriol R, Mulliert G, Gulberti S, Netter P et al. Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway. J Biol Chem 2010; 285: 37342-37358.
    • (2010) J Biol Chem , vol.285 , pp. 37342-37358
    • Talhaoui, I.1    Bui, C.2    Oriol, R.3    Mulliert, G.4    Gulberti, S.5    Netter, P.6
  • 33
    • 3042846793 scopus 로고    scopus 로고
    • A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type
    • Faiyaz-Ul-Haque M, Zaidi SH, Al-Ali M, Al-Mureikhi MS, Kennedy S, Al-Thani G et al. A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type. Am J Med Genet A 2004; 128A: 39-45.
    • (2004) Am J Med Genet A , vol.128 A , pp. 39-45
    • Faiyaz-Ul-Haque, M.1    Zaidi, S.H.2    Al-Ali, M.3    Al-Mureikhi, M.S.4    Kennedy, S.5    Al-Thani, G.6
  • 34
    • 84859560597 scopus 로고    scopus 로고
    • N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients
    • Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE et al. N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients. J Proteome Res 2012; 11: 2282-2300.
    • (2012) J Proteome Res , vol.11 , pp. 2282-2300
    • Alley Jr., W.R.1    Vasseur, J.A.2    Goetz, J.A.3    Svoboda, M.4    Mann, B.F.5    Matei, D.E.6
  • 35
    • 84857881654 scopus 로고    scopus 로고
    • A1-3/4 fucosylation at Asn 241 of b-haptoglobin is a novel marker for colon cancer: A combinatorial approach for development of glycan biomarkers
    • Park SY, Lee SH, Kawasaki N, Itoh S, Kang K, Hee Ryu S et al. a1-3/4 fucosylation at Asn 241 of b-haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers. Int J Cancer 2012; 130: 2366-2376.
    • (2012) Int J Cancer , vol.130 , pp. 2366-2376
    • Park, S.Y.1    Lee, S.H.2    Kawasaki, N.3    Itoh, S.4    Kang, K.5    Hee Ryu, S.6
  • 37
    • 67650996838 scopus 로고    scopus 로고
    • Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens
    • Satomaa T, Heiskanen A, Leonardsson I, Angström J, Olonen A, Blomqvist M et al. Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens. Cancer Res 2009; 69: 5811-5819.
    • (2009) Cancer Res , vol.69 , pp. 5811-5819
    • Satomaa, T.1    Heiskanen, A.2    Leonardsson, I.3    Angström, J.4    Olonen, A.5    Blomqvist, M.6
  • 38
    • 80054726983 scopus 로고    scopus 로고
    • Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation
    • Baran Y, Bielawski J, Gunduz U, Ogretmen B. Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation. J Cancer Res Clin Oncol 2011; 137: 1535-1544.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1535-1544
    • Baran, Y.1    Bielawski, J.2    Gunduz, U.3    Ogretmen, B.4
  • 39
    • 33846902382 scopus 로고    scopus 로고
    • A general role of hedgehog in the regulation of proliferation
    • Agathocleous M, Locker M, Harris WA, Perron M. A general role of hedgehog in the regulation of proliferation. Cell Cycle 2007; 6: 156-159.
    • (2007) Cell Cycle , vol.6 , pp. 156-159
    • Agathocleous, M.1    Locker, M.2    Harris, W.A.3    Perron, M.4
  • 40
    • 1942466507 scopus 로고    scopus 로고
    • Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
    • Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 2004; 18: 937-951.
    • (2004) Genes Dev , vol.18 , pp. 937-951
    • Jeong, J.1    Mao, J.2    Tenzen, T.3    Kottmann, A.H.4    McMahon, A.P.5
  • 41
    • 27144541492 scopus 로고    scopus 로고
    • Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
    • Ma X, Chen K, Huang S, Zhang X, Adegboyega PA, Evers BM et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005; 26: 1698-1705.
    • (2005) Carcinogenesis , vol.26 , pp. 1698-1705
    • Ma, X.1    Chen, K.2    Huang, S.3    Zhang, X.4    Adegboyega, P.A.5    Evers, B.M.6
  • 43
    • 34249878632 scopus 로고    scopus 로고
    • Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport
    • Sims-Mourtada J, Izzo JG, Ajani J, Chao KS. Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007; 26: 5674-5679.
    • (2007) Oncogene , vol.26 , pp. 5674-5679
    • Sims-Mourtada, J.1    Izzo, J.G.2    Ajani, J.3    Chao, K.S.4


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