Rifampicin reduces advanced glycation end products and activates DAF-16 to increase lifespan in Caenorhabditis elegans

Aging Cell

Volumn 14, Issue 3, 2015, Pages 463-473

  Golegaonkar, Sandeep ^a   Tabrez, Syed S ^b   Pandit, Awadhesh ^b   Sethurathinam, Shalini ^b   Jagadeeshaprasad, Mashanipalya G ^a   Bansode, Sneha ^a   Sampathkumar, Srinivasa Gopalan ^b   Kulkarni, Mahesh J ^a   Mukhopadhyay, Arnab ^b  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Caenorhabditis elegans; Advanced glycation end products; Aging; DAF 16; Glycation; Lifespan; Rifampicin

Indexed keywords

ADVANCED GLYCATION END PRODUCT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; QUINONE DERIVATIVE; RIFAMPICIN; RIFAMYCIN; RIFAXIMIN; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; FORKHEAD TRANSCRIPTION FACTOR; INSULIN; TUBERCULOSTATIC AGENT;

ADULT; ADULTHOOD; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; GENE EXPRESSION; GENE EXPRESSION REGULATION; IC50; IN VIVO STUDY; LIFESPAN; LONGEVITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; AGING; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; MUTATION;

CAENORHABDITIS ELEGANS; RICE STRIPE VIRUS;

AGING; ANIMALS; ANTIBIOTICS, ANTITUBERCULAR; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GLYCOSYLATION END PRODUCTS, ADVANCED; INSULIN; LONGEVITY; MUTATION; RIFAMPIN; SIGNAL TRANSDUCTION;

EID: 84927911310     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12327     Document Type: Article

References (45)

1. Ahmed N (2005) Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pract. 67, 3-21.
2. Blackburn K, Goshe MB (2009) Challenges and strategies for targeted phosphorylation site identification and quantification using mass spectrometry analysis. Brief. Funct. Genomic Proteomic 8, 90-103.
3. Bolt HM, Remmer H (1976) Implication of rifampicin-quinone in the irreversible binding of rifampicin to macromolecules. Xenobiotica 6, 21-32.
4. Brummer G, Littlechild S, McCall S, Zhang Y, Conrad GW (2011) The role of nonenzymatic glycation and carbonyls in collagen cross-linking for the treatment of keratoconus. Invest. Ophthalmol. Vis. Sci. 52, 6363-6369.
5. David DC, Ollikainen N, Trinidad JC, Cary MP, Burlingame AL, Kenyon C (2010) Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol. 8, e1000450.
6. Dillin A, Crawford DK, Kenyon C (2002) Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298, 830-834.
7. Golegaonkar SB, Bhonsle HS, Boppana R, Kulkarni MJ (2010) Discovery of rifampicin as a new anti-glycating compound by matrix-assisted laser desorption/ionization mass spectrometry-based insulin glycation assay. Eur. J. Mass Spectrom. (Chichester, Eng) 16, 221-226.
8. Henderson ST, Johnson TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11, 1975-1980.
9. Hipkiss AR (2006) Accumulation of altered proteins and ageing: causes and effects. Exp. Gerontol. 41, 464-473.
10. Hubner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ (2012) JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc. Natl. Acad. Sci. USA 109, 12046-12051.
11. Jung YS, Joe BY, Cho SJ, Konishi Y (2005) 2, 3-Dimethoxy-5-methyl-1, 4-benzoquinones and 2-methyl-1, 4-naphthoquinones: glycation inhibitors with lipid peroxidation activity. Bioorg. Med. Chem. Lett. 15, 1125-1129.
12. Kenyon CJ (2010) The genetics of ageing. Nature 464, 504-512.
13. Enyon C, Murphy CT (2006) Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat. Genet. 38, 397-398; author reply 398.
14. Khalifah RG, Baynes JW, Hudson BG (1999) Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Biochem. Biophys. Res. Commun. 257, 251-258.
15. Konrad P, Stenberg P (1988) Rifampicin quinone is an immunosuppressant, but not rifampicin itself. Clin. Immunol. Immunopathol. 46, 162-166.
16. Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322.
17. Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28, 139-145.
18. Link CD (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 92, 9368-9372.
19. Luevano-Contreras C, Chapman-Novakofski K (2010) Dietary advanced glycation end products and aging. Nutrients 2, 1247-1265.
20. Matsukawa J, Matsuzawa A, Takeda K, Ichijo H (2004) The ASK1-MAP kinase cascades in mammalian stress response. J. Biochem. 136, 261-265.
21. McGee MD, Weber D, Day N, Vitelli C, Crippen D, Herndon LA, Hall DH, Melov S (2011) Loss of intestinal nuclei and intestinal integrity in aging C. elegans. Aging Cell 10, 699-710.
22. Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H (1999) The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc. Natl. Acad. Sci. USA 96, 7427-7432.
23. Morcos M, Du X, Pfisterer F, Hutter H, Sayed AA, Thornalley P, Ahmed N, Baynes J, Thorpe S, Kukudov G, Schlotterer A, Bozorgmehr F, El Baki RA, Stern D, Moehrlen F, Ibrahim Y, Oikonomou D, Hamann A, Becker C, Zeier M, Schwenger V, Miftari N, Humpert P, Hammes HP, Buechler M, Bierhaus A, Brownlee M, Nawroth PP (2008) Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans. Aging Cell 7, 260-269.
24. Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283.
25. Nakamura A, Yasuda K, Adachi H, Sakurai Y, Ishii N, Goto S (1999) Vitellogenin-6 is a major carbonylated protein in aged nematode, Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 264, 580-583.
26. Nedic O, Rattan SI, Grune T, Trougakos IP (2013) Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology. Free Radical Res. 47(Suppl 1), 28-38.
27. Ogg S, Ruvkun G (1998) The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2, 887-893.
28. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999.
29. Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA (2005) JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 102, 4494-4499.
30. Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA (2006) Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat. Genet. 38, 251-257.
31. Paradis S, Ruvkun G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12, 2488-2498.
32. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13, 1438-1452.
33. Rabbani N, Thornalley PJ (2011) Glyoxalase in diabetes, obesity and related disorders. Semin. Cell Dev. Biol. 22, 309-317.
34. Semba RD, Nicklett EJ, Ferrucci L (2010) Does accumulation of advanced glycation end products contribute to the aging phenotype? J. Gerontol. A Biol. Sci. Med. Sci. 65, 963-975.
35. Shore DE, Ruvkun G (2013) A cytoprotective perspective on longevity regulation. Trends Cell Biol. 23, 409-420.
36. Silva JC, Denny R, Dorschel C, Gorenstein MV, Li GZ, Richardson K, Wall D, Geromanos SJ (2006) Simultaneous qualitative and quantitative analysis of the Escherichia coli proteome: a sweet tale. Mol. Cell Proteomics 5, 589-607.
37. Singh R, Barden A, Mori T, Beilin L (2001) Advanced glycation end-products: a review. Diabetologia 44, 129-146.
38. Sodhi CP, Rana S, Mehta S, Vaiphei K, Goel RC, Mehta SK (1997) Study of oxidative-stress in rifampicin-induced hepatic injury in growing rats with and without protein-energy malnutrition. Hum. Exp. Toxicol. 16, 315-321.
39. Thornalley PJ (2008) Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems-role in ageing and disease. Drug Metabol. Drug Interact. 23, 125-150.
40. Ulrich P, Cerami A (2001) Protein glycation, diabetes, and aging. Recent Prog. Horm. Res. 56, 1-21.
41. Van Nostrand EL, Sanchez-Blanco A, Wu B, Nguyen A, Kim SK (2013) Roles of the developmental regulator unc-62/homothorax in limiting longevity in Caenorhabditis elegans. PLoS Genet. 9, e1003325.
42. Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL (2007) Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 11, 555-569.
43. Wang MC, Bohmann D, Jasper H (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125.
44. Xie H, Gilar M, Gebler JC (2009) Characterization of protein impurities and site-specific modifications using peptide mapping with liquid chromatography and data independent acquisition mass spectrometry. Anal. Chem. 81, 5699-5708.
45. Xue M, Rabbani N, Thornalley PJ (2011) Glyoxalase in ageing. Semin. Cell Dev. Biol. 22, 293-301.