Cathepsin K knockout alleviates aging-induced cardiac dysfunction

Aging Cell

Volumn 14, Issue 3, 2015, Pages 345-351

  Hua, Yinan ^a   Robinson, Timothy J ^b   Cao, Yongtao ^c   Shi, Guo Ping ^d   Ren, Jun ^a   Nair, Sreejayan ^a  

^a UNIVERSITY OF WYOMING SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^c INDIANA UNIVERSITY OF PENNSYLVANIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; Apoptosis; Cardiac function; Cardiac hypertrophy; Cardiac remodeling; Cathepsin K

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; CATHEPSIN K; DOXORUBICIN; LIPOFUSCIN; PROTEIN KINASE B; PROTEIN P16; PROTEIN P21; SOMATOMEDIN C; CASPASE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CELL AGING; CELL CYCLE REGULATION; CELL NUCLEUS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE INACTIVATION; HEART DISEASE; HEART FUNCTION; HEART HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART PERFORMANCE; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; LIVER WEIGHT; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WEIGHT GAIN; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE CELL; CARDIOMEGALY; CELL CULTURE; GENETICS; HEART CONTRACTION; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION;

MUS;

AGING; ANIMALS; APOPTOSIS; CARDIOMEGALY; CASPASES; CATHEPSIN K; CELLS, CULTURED; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC;

EID: 84927909979     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12276     Document Type: Article

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