The role of ghrelin in metabolic regulation

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 17, Issue 6, 2014, Pages 497-502

  Pinkney, Jonathan ^a  

^a PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

Author keywords

Ghrelin; Glucose; Insulin; Lipids

Indexed keywords

CARBOHYDRATE; FATTY ACID; GHRELIN; GLUCOSE; INSULIN; LEPTIN; GHRELIN, DES-N-OCTANOYL;

AGING; APPETITE; CARBOHYDRATE METABOLISM; ENERGY BALANCE; ENERGY CONSERVATION; ENZYME REGULATION; ENZYME REPRESSION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HEART PROTECTION; HUMAN; HUNGER; INSULIN RELEASE; LIPID METABOLISM; NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; POSTPRANDIAL STATE; REVIEW; SATIETY; ADIPOGENESIS; BLOOD; ENERGY METABOLISM; HOMEOSTASIS; METABOLISM; PHYSIOLOGY; WEIGHT GAIN;

ADIPOGENESIS; APPETITE; ENERGY METABOLISM; GHRELIN; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; LEPTIN; LIPID METABOLISM; POSTPRANDIAL PERIOD; SATIATION; WEIGHT GAIN;

EID: 84927796180     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000101     Document Type: Review

References (39)

1. Sangiao-Alvarellos S, Cordido F. Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. Int J Pept 2010; article ID 234709.
2. Heppner KM, Muller TD, Tong J, Tschop MH. Ghrelin in the control of venergy, lipid, and glucose metabolism.Methods Enzymol 2012; 514:249-260.
3. Heppner KM, Tong J, Kirchner H, et al. The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism. Curr Opin Endocrinol Diabetes Obes 2011; 18:50-55.
4. Delhanty PJ, Neggers SJ, van der Lely AJ. Mechanisms in endocrinology: ghrelin: the differences between acyl-and des-acyl ghrelin. Eur J Endocrinol 2012; 167:601-608.
5. Heppner KM, Piechowski CL, Muller A, et al. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes 2014; 63:122-131.
6. Stevanovic DM, Grefhorst A, Themmen AP, et al. Unacylated ghrelin suppresses grelin-induced neuronal activity in the hypothalamus and brainstem of male rats. PLoS One 2014; 9:e98180.
7. Shimada T, Furuta H, Doi A, et al. Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway. Metabolism 2014; 63:469-474.
8. Rodriguez A, Gomez-Ambrosi J, Catalan V, et al. Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Int J Obes (Lond) 2009; 33:541-552.
9. Cederberg H, Koivisto VM, Jokelainen J, et al. Unacylated ghrelin is associated with changes in insulin sensitivity and lipid profile during an exercise intervention. Clin Endocrinol (Oxf) 2012; 76:39-45.
10. St-Onge MP. The role of sleep duration in the regulation of energy balance: effects on energy intakes and expenditure. J Clin Sleep Med 2013; 9:73-80.
11. Spiegel K, Tasali E, Leproult R, et al. Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J Clin Endocrinol Metab 2011; 96:486-493.
12. Delhanty PJ, Neggers SJ, van der Lely AJ. Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do? Front Horm Res 2014; 42:163-174.
13. Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 2010; 59:2145-2151.
14. Kiewiet RM, van Aken MO, van der Weerd K, et al. Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes. Eur J Endocrinol 2009; 161:567-573.
15. Tong J, Davis HW, Summer S, et al. Acute administration of unacylated ghrelin has no effect on basal or stimulated insulin secretion in healthy humans. Diabetes 2014; 63:2309-2319.
16. Chacko SK, Haymond MW, Sun Y, et al. Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab 2012; 302:E1055-E1062.
17. Dezaki K. Ghrelin function in insulin release and glucose metabolism. Endocr Dev 2013; 25:135-143.
18. Vestergaard ET, Moller N, Jorgensen JO. Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects. Am J Physiol Endocrinol Metab 2013; 304:E1273-E1280.
19. Sakata I, Park WM, Walker AK, et al. Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells. Am J Physiol Endocrinol Metab 2012; 302:E1300-E1310.
20. Knudsen SH, Karstoft K, Solomon TP. Hyperglycemia abolishes meal-induced satiety by a dysregulation of ghrelin and peptide YY3-36 in healthy overweight/ obese humans. Am J Physiol Endocrinol Metab 2014; 306:E225-E231.
21. Wang Q, Liu C, Uchida A, et al. Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin. Mol Metab 2013; 3:64-72.
22. Briggs DI, Lockie SH, Benzler J, et al. Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice. Endocrinology 2014; 155:2411-2422.
23. Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006; 116:1983-1993.
24. Dieguez C, Vazquez MJ, Romero A, et al. Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins. Neuroendocrinology 2011; 94:1-11.
25. Davies JS, Kotokorpi P, Eccles SR, et al. Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol 2009; 23:914-924.
26. Porteiro B, Diaz-Ruiz A, Martinez G, et al. Ghrelin requires p53 to stimulate lipid storage in fat and liver. Endocrinology 2013; 154:3671-3679.
27. Rodriguez A, Gomez-Ambrosi J, Catalan V, et al. The ghrelin O-acyltransferase-ghrelin system reduces TNF-alpha-induced apoptosis and autophagy in human visceral adipocytes. Diabetologia 2012; 55:3038-3050.
28. Qi L, Cui X, Dong W, et al. Ghrelin protects rats against traumatic brain injury and hemorrhagic shock through upregulation of UCP2. Ann Surg 2014; 260:169-178.
29. Stoyanova II, le Feber J, Rutten WL. Ghrelin stimulates synaptic formation in cultured cortical networks in a dose-dependent manner. Regul Pept 2013; 186:43-48.
30. Nesic DM, Stevanovic DM, Stankovic SD, et al. Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats. Eur J Pharmacol 2013; 710:85-91.
31. Buss J, Havel PJ, Epel E, et al. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 2014; 76:84-94.
32. Goldstone AP, Prechtl CG, Scholtz S, et al. Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food. Am J Clin Nutr 2014; 99:1319-1330.
33. Sun X, Veldhuizen MG, Wray AE, et al. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiol Behav 2014. [Epub ahead of print]. doi: 10.1016/j.physbeh.2014.04.017.
34. Huda MS, Dovey T, Wong SP, et al. Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects. Int J Obes (Lond) 2009; 33:317-325.
35. Nisembaum LG, de Pedro N, Delgado MJ, Isorna E. Crosstalking between the 'gut-brain' hormone ghrelin and the circadian system in the goldfish. Effects on clock gene expression and food anticipatory activity. Gen Comp Endocrinol 2014. [Epub ahead of print]. doi: 10.1016/j.ygcen.2014.03.016.
36. Leggio L, Zywiak WH, Fricchione SR, et al. Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigation. Biol Psychiatry 2014. [Epub ahead of print]. doi: 10.1016/j.biopsych.2014.03.019.
37. Vengeliene V. The role of ghrelin in drug and natural reward. Addict Biol 2013; 18:897-900.
38. Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med 2011; 365:1597-1604.
39. Crujeiras AB, Diaz-Lagares A, Abete I, et al. Pretreatment circulating leptin/ ghrelin ratio as a noninvasive marker to identify patients likely to regain the lost weight after an energy restriction treatment. J Endocrinol Invest 2014; 37:119-126.