Gestational age-specific reference ranges of hepcidin in cord blood

Neonatology

Volumn 106, Issue 2, 2014, Pages 133-139

  Lorenz, Laila ^a   Herbst, Johanna ^a   Engel, Corinna ^a   Peter, Andreas ^b   Abele, Harald ^a   Poets, Christian F ^a   Westerman, Mark ^b   Franz, Axel R ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b Center for Pediatric Clinical Studies University Children's Hospital of Tübingen Metabolism Pathobiochemistry and Clinical Chemistry ^*  (United States)

Author keywords

Cord blood; Gestational age specific reference values; Hepcidin; Iron deficiency; Premature infant

Indexed keywords

FERRITIN; HEPCIDIN; IRON; AUTACOID; BIOLOGICAL MARKER; HEMOGLOBIN; C REACTIVE PROTEIN; INTERLEUKIN 6;

ARTICLE; BIRTH WEIGHT; CESAREAN SECTION; ENTEROCOCCUS FAECALIS; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; OBSERVATIONAL STUDY; PREMATURITY; PRIORITY JOURNAL; SCORING SYSTEM; SEPSIS; UMBILICAL CORD BLOOD; VAGINAL DELIVERY; AGE; ANEMIA, IRON-DEFICIENCY; BLOOD; CASE CONTROL STUDY; CHEMISTRY; DELIVERY; FETAL GROWTH RETARDATION; FETUS BLOOD; GRAM-POSITIVE BACTERIAL INFECTIONS; ISOLATION AND PURIFICATION; LOW BIRTH WEIGHT; MICROBIOLOGY; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE; PROSPECTIVE STUDY; REFERENCE VALUE; RISK; STATISTICAL MODEL; ACIDOSIS; BLOOD CELL COUNT; FERRITIN BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HORMONE BLOOD LEVEL; INFLAMMATION; MEAN CORPUSCULAR VOLUME; PREGNANCY DIABETES MELLITUS; PROTEIN BLOOD LEVEL;

ENTEROCOCCUS FAECALIS;

AGE FACTORS; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL MARKERS; BIRTH WEIGHT; CASE-CONTROL STUDIES; DELIVERY, OBSTETRIC; ENTEROCOCCUS FAECALIS; FEMALE; FERRITINS; FETAL BLOOD; FETAL GROWTH RETARDATION; GESTATIONAL AGE; GRAM-POSITIVE BACTERIAL INFECTIONS; HEMOGLOBINS; HEPCIDINS; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFLAMMATION MEDIATORS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REFERENCE VALUES; SEPSIS;

EID: 84927785918     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000360072     Document Type: Article

References (25)

1. Lorenz L Peter A Poets CF Franz AR: A review of cord blood concentrations of iron status parameters to define reference ranges for preterm infants. Neonatology 2013; 104: 194-202.
2. Briana DD Boutsikou T Baka S Boutsikou M Stamati L Hassiakos D Gourgiotis D Malamitsi-Puchner A: Perinatal role of hepcidin and iron homeostasis in full-term intrauterine growth-re stricted infants. Eur J Haematol 2013; 90: 37-44.
3. Niklasson A Engstrom E Hard AL Wikland KA Hellstrom A: Growth in very preterm children: a longitudinal study. Pediatr Res 2003; 54: 899-905.
4. Widness JA Madan A Grindeanu LA Zimmerman MB Wong DK Stevenson DK: Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-l ine blood gas and chemistry monitor. Pediatrics 2005; 115: 1299-1306.
5. Rabe H Reynolds G Diaz-Rossello J: A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants. Neonatology 2008; 93: 138-144.
6. Steinmacher J Pohlandt F Bode H Sander S Kron M Franz AR: Randomized trial of early versus late enteral iron supplementation in infan ts with a birth weight of less than 1,301 grams: neurocognitive development at 5.3 years' corrected age. Pediatrics 2007; 120: 538-546.
7. Agostoni C Buonocore G Carnielli VP De Curtis M Darmau n D Decsi T Domellof M Embleton ND Fusch C Genzel-Boroviczeny O Goulet O Kalhan SC Kolacek S Koletzko B Lapillonne A Mihatsch W Moreno L Neu J Poindexter B Puntis J Putet G Rigo J Riskin A Salle B Sauer P Shamir R Szajewska H Thureen P Turck D van Goudoever JB Ziegler EE: Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroe nterology Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50: 85-91.
8. Muller KF Lorenz L Poets CF Westerman M Franz AR: Hepcidin concentrations in se rum and urine correlate with iron homeostasis in preterm infants. J Pediatr 2012; 160: 949-953.e2.
9. Ganz T Olbina G Girelli D Nemeth E Westerman M: Immunoassay for human serum hepcidin. Blood 2008; 112: 4292-4297.
10. Freeman JV Cole TJ Chinn S Jones PR White EM Preece MA: Cross sectional stature and weight reference curves for the UK 1990. Arch Dis Child 1995; 73: 17-24.
11. Shao J Lou J Rao R Georgieff MK Kaciroti N Felt BT Zhao ZY Lozoff B: Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012 ; 142: 2004-2009.
12. Rehu M Punnonen K Ostland V Heinonen S Westerman M Pulkki K Sankilampi U: Maternal serum hepcidin is low at term and independent of cord blood iron status. E ur J Haematol 2010; 85: 345-352.
13. Wu TW Tabangin M Kusano R Ma Y Ridsdale R Akinbi H: The utility of serum hepcidin as a biomarker for late-onset neonatal sepsis. J Pediatr 2013; 162: 67-71.
14. Berglund S Lonnerdal B Westrup B Domellof M: Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants. Am J Clin Nutr 2011; 94: 1553-1561.
15. Nicolas G Chauvet C Viatte L Danan JL Bigard X Devaux I Beaumont C Kahn A Vaulont S: The gene encoding the iron regulatory peptide hepcidin is regulated by ane mia hypoxia and inflammation. J Clin Invest 2002; 110: 1037-1044.
16. Bastin J Drakesmith H Rees M Sargent I Townsend A Localisation of proteins of iron metabolism in the human placenta and liver Br J Haematol 2006 134 532-543.
17. Nemeth E Tuttle MS Powelson J Vaughn MB Donovan A Ward DM Ganz T Kaplan J: Hepcidin regulates cellular iron efflux by bindi ng to ferroportin and inducing its internalization. Science 2004; 306: 2090-2093.
18. Muller KF Lorenz L Poets CF Westerman M Franz AR: Hepcidin concentrations in serum and urine correlate with iron homeostasis in preterm infants. J Pediatr 2012; 160: 949-953.e2.
19. Mando C Tabano S Colapietro P Pileri P Colleoni F Avagliano L Doi P Bulfamante G Miozzo M Ce tin I: Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas. Placenta 2011; 32: 44-50.
20. Schwarz P Strnad P von Figura G Janetzko A Krayenbuhl P Adler G Kulaksiz H: A novel monoclonal antibody immunoassay for the detection of human serum hepcidin. J Gastroenterol 2011; 46: 648-656.
21. Verner AM Manderson J Lappin TR Mc-Cance DR Halliday HL Sweet DG: Influence of maternal diabetes mellitus on fetal iron status. Arch Dis Child Fetal Neonatal Ed 2007; 92:F399-F401.
22. Piperno A Galimberti S Mariani R Pelucchi S Ravasi G Lombardi C Bilo G Revera M Giuliano A Faini A Mainini V Westerman M Ganz T Valsecchi MG Mancia G Parati G: Modulation of hepcidin production during hypoxia-induce d erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood 2011; 117: 2953-2959.
23. Nemeth E Rivera S Gabayan V Keller C Taudorf S Pedersen BK Ganz T: IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 20 04; 113: 1271-1276.
24. Franz AR Steinbach G Kron M Pohlandt F: Interleukin-8: a valuable tool to restrict antibiotic therapy in newborn infants. Acta Paediatr 2001; 90: 1025-1032.
25. Malamitsi-Puchner A Protonotariou E Boutsikou T Makrakis E Sarandakou A Creatsas G: The influence of the mode of delivery on circulating cytokine concentrations in the perinatal period. Early Hum Dev 2005; 81: 387-392.