Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in Late Pregnancy1-3

Journal of Nutrition

Volumn 142, Issue 11, 2012, Pages 2004-2009

  Shao, Jie ^a,b   Lou, Jingan ^b   Rao, Raghavendra ^c   Georgieff, Michael K ^c   Kaciroti, Niko ^d   Felt, Barbara T ^d   Zhao, Zheng Yan ^a,b   Lozoff, Betsy ^d  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEMOGLOBIN;

ADULT; ANEMIA; ARTICLE; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; IRON STORAGE; LINEAR REGRESSION ANALYSIS; MATERNAL SERUM; NEWBORN; PREGNANCY; PREGNANT WOMAN; THIRD TRIMESTER PREGNANCY; UMBILICAL CORD BLOOD;

ADULT; ANEMIA, IRON-DEFICIENCY; CHINA; FEMALE; FERRITINS; FETAL BLOOD; HUMANS; INFANT, NEWBORN; IRON; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; YOUNG ADULT;

EID: 84869118579     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.162362     Document Type: Article

References (55)

1. Beard J. Recent evidence from human and animal studies regarding iron status and infant development. J Nutr. 2007;137:S524-30.
2. Unger EL, Paul T, Murray-Kolb LE, Felt B, Jones BC, Beard JL. Early iron deficiency alters sensorimotor development and brain monoamines in rats. J Nutr. 2007;137:118-24.
3. Wu LL, Zhang L, Shao J, Qin YF, Yang RW, Zhao ZY. Effect of perinatal iron deficiency on myelination and associated behaviors in rat pups. Behav Brain Res. 2008;188:263-70.
4. Ward KL, Tkac I, Jing Y, Felt B, Beard J, Connor J, Schallert T, Georgieff MK, Rao R. Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats. J Nutr. 2007;137:1043-9.
5. Golub MS, Hogrefe CE, Tarantal AF, Germann SL, Beard JL, Georgieff MK, Calatroni A, Lozoff B. Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys. Am J Clin Nutr. 2006;83: 647-56.
6. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long- lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64:S34-43.
7. Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140:165-70.
8. Bothwell TH. Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr. 2000;72:S257-64.
9. Harris ED. New insights into placental iron transport. Nutr Rev. 1992;50:329-31.
10. Starreveld JS, Kroos MJ, Van Suijlen JD, Verrijt CE, Van Eijk HG, Van Dijk JP. Ferritin in cultured human cytotrophoblasts: synthesis and subunit distribution. Placenta. 1995;16:383-95.
11. Petry CD, Wobken JD, McKay H, Eaton MA, Seybold VS, Johnson DE, Georgieff MK. Placental transferrin receptor in diabetic pregnancies with increased fetal iron demand. Am J Physiol. 1994;267:E507-14.
12. Young MF, Pressman E, Foehr ML, McNanley T, Cooper E, Guillet R, Orlando M, McIntyre AW, Lafond J, O'Brien KO. Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents. Placenta. 2010;31:1010-4.
13. Gambling L, Lang C, McArdle HJ. Fetal regulation of iron transport during pregnancy. Am J Clin Nutr. 2011;94 Suppl:S1903-7.
14. Bradley J, Leibold EA, Harris ZL, Wobken JD, Clarke S, Zumbrennen KB, Eisenstein RS, Georgieff MK. Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta. Am J Physiol Regul Integr Comp Physiol. 2004;287:R894-901.
15. Oski FA. Iron deficiency in infancy and childhood. N Engl J Med. 1993; 329:190-3.
16. Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71:S1280-4.
17. Lao TT, Loong EP, Chin RK, Lam CW, Lam YM. Relationship between newborn and maternal iron status and haematological indices. Biol Neonate. 1991;60:303-7.
18. MacPhail AP, Charlton RW, Bothwell TH, Torrance JD. The relation- ship between maternal and infant iron status. Scand J Haematol. 1980;25:141-50.
19. Emery D, Barry D. Comparison of Maori and non-Maori maternal and fetal iron parameters. N Z Med J. 2004;117:U909.
20. Ervasti M, Sankilampi U, Heinonen S, Punnonen K. Early signs of maternal iron deficiency do not influence the iron status of the newborn, but are associated with higher infant birthweight. Acta Obstet Gynecol Scand. 2009;88:83-90.
21. Agrawal RM, Tripathi AM, Agarwal KN. Cord blood haemoglobin, iron and ferritin status in maternal anaemia. Acta Paediatr Scand. 1983;72:545-8.
22. Singla PN, Chand S, Khanna S, Agarwal KN. Effect of maternal anaemia on the placenta and the newborn infant. Acta Paediatr Scand. 1978;67:645-8.
23. Sweet DG, Savage G, Tubman TR, Lappin TR, Halliday HL. Study of maternal influences on fetal iron status at term using cord blood transferrin receptors. Arch Dis Child Fetal Neonatal Ed. 2001;84:F40-3.
24. Gaspar MJ, Ortega RM, Moreiras O. Relationship between iron status in pregnant women and their newborn babies. Investigation in a Spanish population. Acta Obstet Gynecol Scand. 1993;72:534-7.
25. Bhargava M, Kumar R, Iyer PU, Ramji S, Kapani V, Bhargava SK. Effect of maternal anaemia and iron depletion on foetal iron stores, birthweight and gestation. Acta Paediatr Scand. 1989;78:321-2.
26. Nhonoli AM, Kihama FE, Ramji BD. The relation between maternal and cord serum iron levels and its effect on fetal growth in iron deficient mothers without malarial infection. Br J Obstet Gynaecol. 1975;82: 467-70.26.
27. Liao QK. Chinese Children, Pregnant Women and Premenopausal Women Iron Deficiency Epidemiological Survey Group. Prevalence of iron deficiency in pregnant and premenopausal women in China: a nationwide epidemiological survey. Zhonghua Xue Ye Xue Za Zhi. 2004;25:653-7.
28. Siddappa AM, Rao R, Long JD, Widness JA, Georgieff MK. The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations. Neonatology. 2007;92:73-82.
29. CDC. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep. 1998;47:1-29.
30. Diagne I, Archambeaud MP, Diallo D, d'Oiron R, Yvart J, Tchernia G. Erythrocyte indices and iron stores in cord blood [in French]. Arch Pediatr. 1995;2:208-14.
31. Paterakis GS, Lykopoulou L, Papassotiriou J, Stamulakatou A, Kattamis C, Loukopoulos D. Flow-cytometric analysis of reticulocytes in normal cord blood. Acta Haematol. 1993;90:182-5.
32. Amin SB, Orlando M, Eddins A, MacDonald M, Monczynski C, Wang H. In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response. J Pediatr. 2010;156:377-81.
33. Siddappa AM, Georgieff MK, Wewerka S, Worwa C, Nelson CA, Deregnier RA. Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers. Pediatr Res. 2004;55:1034-41.
34. Joram N, Boscher C, Denizot S, Loubersac V, Winer N, Roze JC, Gras- Le Guen C. Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection. Arch Dis Child Fetal Neonatal Ed. 2006;91:F65-6.
35. McGee VE. Piecewise regression. J Am Stat Assoc. 1970;65:1109-24.
36. Hussain MA, Gaafar TH, Laulicht M, Hoffebrand AV. Relation of maternal and cord blood serum ferritin. Arch Dis Child. 1977;52:782-4.
37. Harthoorn-Lasthuizen EJ, Lindemans J, Langenhuijsen MM. Does iron- deficient erythropoiesis in pregnancy influence fetal iron supply? Acta Obstet Gynecol Scand. 2001;80:392-6.
38. Kumar A, Rai AK, Basu S, Dash D, Singh JS. Cord blood and breast milk iron status in maternal anemia. Pediatrics. 2008;121:e673-7.
39. Akhter S, Momen MA, Rahman MM, Parveen T, Karim RK. Effect of maternal anemia on fetal outcome. Mymensingh Med J. 2010;19:391-8.
40. Kelly AM, MacDonald DJ, McDougall AN. Observations on maternal and fetal ferritin concentrations at term. Br J Obstet Gynaecol. 1978; 85:338-43.
41. Cook JD. Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol. 2005;18:319-32.
42. Hay G, Refsum H, Whitelaw A, Melbye EL, Haug E, Borch-Iohnsen B. Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life. Am J Clin Nutr. 2007;86:64-73.
43. Strauss MB. Anemia of infancy from maternal iron deficiency in pregnancy. J Clin Invest. 1933;12:345-53.
44. Preziosi P, Prual A, Galan P, Daouda H, Boureima H, Hercberg S. Effect of iron supplementation on the iron status of pregnant women: consequences for newborns. Am J Clin Nutr. 1997;66:1178-82.
45. Kilbride J, Baker TG, Parapia LA, Khoury SA, Shuqaidef SW, Jerwood D. Anaemia during pregnancy as a risk factor for iron-deficiency anaemia in infancy: a case-control study in Jordan. Int J Epidemiol. 1999;28:461-8.
46. Chi IC, Agoestina T, Harbin J. Maternal mortality at twelve teaching hospitals in Indonesia: an epidemiologic analysis. Int J Gynaecol Obstet. 1981;19:259-66.
47. Liao QK, Kong PA, Gao J, Li FY, Qian ZM. Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation. Eur J Clin Nutr. 2001;55:651-6.
48. O'Brien KO, Zavaleta N, Abrams SA, Caulfield LE. Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy. Am J Clin Nutr. 2003;77:924-30.
49. Türkey S, Tanzer F, Gultekin A, Bakici MZ. The influence of maternal iron deficiency anemia on haemoglobin concentration of the infant. J Trop Pediatr. 1995;41:369-71.
50. Fullerton HW. The iron-deficiency anaemia of late infancy. Arch Dis Child. 1937;12:91-110.
51. Georgieff MK, Landon MB, Mills MM, Hedlund BE, Faassen AE, Schmidt RL, Ophoven JJ, Widness JA. Abnormal iron distribution in infants of diabetic mothers: spectrum and maternal antecedents. J Pediatr. 1990;117:455-61.
52. Chockalingam UM, Murphy E, Ophoven JC, Weisdorf SA, Georgieff MK. Cord transferrin and ferritin values in newborn infants at risk for prenatal utroplacental insufficiency and chronic hypoxia. J Pediatr. 1987;111:283-6.
53. Yang GH, Ma JM, Liu N, Zhou LN. Smoking and passive smoking in China, 2002 [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:77-83.
54. Lubach GR, Coe CL. Preconception maternal iron status is a risk factor for iron deficiency in infant rhesus monkeys (Macaca mulatta). J Nutr. 2006;136:2345-9.
55. Ronnenberg AG, Wood RJ, Wang X, Xing H, Chen C, Chen D, Guang W, Huang A, Wang L, Xu X. Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women. J Nutr. 2004;134:2586-91.