The utility of serum hepcidin as a biomarker for late-onset neonatal sepsis

Journal of Pediatrics

Volumn 162, Issue 1, 2013, Pages 67-71

  Wu, Tai Wei ^a   Tabangin, Meredith ^c   Kusano, Ryosuke ^b   Ma, Yan ^c   Ridsdale, Ross ^c   Akinbi, Henry ^c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

C reactive protein; CART; Classification and regression tree; Coefficient of variation; CRP; CV; ln; Natural logarithmic; Negative predictive value; NPV; Positive predictive value; PPV; Very low birth weight; VLBW

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; HEPCIDIN;

ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; INFANT; MALE; NEWBORN; NEWBORN SEPSIS; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; VERY LOW BIRTH WEIGHT;

AGE OF ONSET; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; MALE; PREDICTIVE VALUE OF TESTS; SEPSIS;

EID: 84871393007     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2012.06.010     Document Type: Article

References (23)

1. A. Borghesi, and M. Stronati Strategies for the prevention of hospital-acquired infections in the neonatal intensive care unit J Hosp Infect 68 2008 293 300
2. B.J. Stoll, and N. Hansen Infections in VLBW infants: studies from the NICHD Neonatal Research Network Semin Perinatol 27 2003 293 301 (Pubitemid 37099810)
3. B.J. Stoll, N.I. Hansen, and I. Adams-Chapman Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection JAMA 292 2004 2357 2365 (Pubitemid 39491920)
4. T.G. Connell, M. Rele, D. Cowley, J.P. Buttery, and N. Curtis How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a childre's hospital Pediatrics 119 2007 891 896 (Pubitemid 46715658)
5. J.A. Kellogg, F.L. Ferrentino, M.H. Goodstein, J. Liss, S.L. Shapiro, and D.A. Bankert Frequency of low level bacteremia in infants from birth to two months of age Pediatr Infect Dis J 16 1997 381 385 (Pubitemid 27172958)
6. J.D. Edgar, V. Gabriel, J.R. Gallimore, S.A. McMillan, and J. Grant A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection BMC Pediatr 10 2010 22
7. T.B. Newman, K.M. Puopolo, S. Wi, D. Draper, and G.J. Escobar Interpreting complete blood counts soon after birth in newborns at risk for sepsis Pediatrics 126 2010 903 909
8. E. Kemna, P. Pickkers, E. Nemeth, H. van der Hoeven, and D. Swinkels Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS Blood 106 2005 1864 1866 (Pubitemid 41208606)
9. E. Nemeth, S. Rivera, V. Gabayan, C. Keller, S. Taudorf, and B.K. Pedersen IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 113 2004 1271 1276 (Pubitemid 39069926)
10. S.I. Patruta, and W.H. Horl Iron and infection Kidney Int Suppl 69 1999 S125 S130
11. K.F. Müller, L. Lorenz, C.F. Poets, M. Westerman, and A.R. Franz Hepcidin Concentrations in Serum and Urine Correlate with Iron Homeostasis in Preterm Infants J Pediatr 2012
12. T. Ganz, G. Olbina, D. Girelli, E. Nemeth, and M. Westerman Immunoassay for human serum hepcidin Blood 112 2008 4292 4297
13. R.A. Polin, and T.M. Randis Biomarkers for late-onset neonatal sepsis Genome Med 2 2010 58
14. D. Vyoral, and J. Petrak Hepcidin: a direct link between iron metabolism and immunity Int J Biochem Cell Biol 37 2005 1768 1773 (Pubitemid 40961662)
15. S.T. Ong, J.Z. Ho, B. Ho, and J.L. Ding Iron-withholding strategy in innate immunity Immunobiology 211 2006 295 314
16. P. Valenti, F. Berlutti, M.P. Conte, C. Longhi, and L. Seganti Lactoferrin functions: current status and perspectives J Clin Gastroenterol 38 2004 S127 S129
17. M.F. Macedo, M. de Sousa, R.M. Ned, C. Mascarenhas, N.C. Andrews, and M. Correia-Neves Transferrin is required for early T-cell differentiation Immunology 112 2004 543 549 (Pubitemid 39061478)
18. M.H. Dörner, A. Silverstone, K. Nishiya, A. de Sostoa, G. Munn, and M. de Sousa Ferritin synthesis by human T lymphocytes Science 209 1980 1019 1021 (Pubitemid 10014876)
19. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, and D.M. Ward Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093 (Pubitemid 40007660)
20. A. Cuesta, J. Meseguer, and M.A. Esteban The antimicrobial peptide hepcidin exerts an important role in the innate immunity against bacteria in the bony fish gilthead seabream Mol Immunol 45 2008 2333 2342
21. M. Ervasti, U. Sankilampi, S. Luukkonen, S. Heinonen, and K. Punnonen Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth Eur J Obstet Gynecol Reprod Biol 147 2009 161 165
22. S.S. Bansal, J.M. Halket, A. Bomford, R.J. Simpson, N. Vasavda, and S.L. Thein Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry Anal Biochem 384 2009 245 253
23. M.A. Verboon-Maciolek, S.F. Thijsen, M.A. Hemels, M. Menses, A.M. van Loon, and T.G. Krediet Inflammatory mediators for the diagnosis and treatment of sepsis in early infancy Pediatr Res 59 2006 457 461 (Pubitemid 43740088)