Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes

Respiratory Research

Volumn 16, Issue 1, 2015, Pages

  Hodge, Greg ^a,b   Jersmann, Hubertus ^a,b   Tran, Hai B ^a   Holmes, Mark ^a,b   Reynolds, Paul N ^a,b   Hodge, Sandra ^a,b  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

CD28null T and NKT like cells; COPD; Glucocorticoid receptor; IFN and TNF ; Lymphocyte senescence

Indexed keywords

CD28 ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; PGP1 PROTEIN; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ABCB1 PROTEIN, HUMAN; AUTACOID; CYTOKINE; GLUCOCORTICOID; MULTIDRUG RESISTANCE PROTEIN;

ADULT; ARTICLE; CD28 POSITIVE CD28 POSITIVE T LYMPHOCYTE; CD28 POSITIVE T LYMPHOCYTE; CELL AGING; CELL STIMULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; MALE; NATURAL KILLER T CELL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETROSPECTIVE STUDY; STEROID BINDING; T LYMPHOCYTE; AGED; AGONISTS; BLOOD; CASE CONTROL STUDY; CD8+ T LYMPHOCYTE; DRUG EFFECTS; DRUG RESISTANCE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

ADULT; AGED; ANTIGENS, CD28; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CYTOKINES; DOWN-REGULATION; DRUG RESISTANCE; FEMALE; FLOW CYTOMETRY; GLUCOCORTICOIDS; HUMANS; INFLAMMATION MEDIATORS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NATURAL KILLER T-CELLS; P-GLYCOPROTEINS; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, GLUCOCORTICOID;

EID: 84927745311     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-014-0161-7     Document Type: Article

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