Characterization of CD4+CD28null T cells in patients with coronary artery disease and individuals with risk factors for atherosclerosis

Cellular Immunology

Volumn 281, Issue 1, 2013, Pages 11-19

  Téo, Fábio Haach ^a   de Oliveira, Rômulo Tadeu Dias ^a   Mamoni, Ronei Luciano ^a   Ferreira, Maria Carolina Salmora ^a   Nadruz, Wilson ^a   Coelho, Otávio Rizzi ^a   Fernandes, Juliano de Lara ^a   Blotta, Maria Heloisa Souza Lima ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Atherosclerosis; CD4+CD28null cells; Inflammation; Risk factors

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; GRANULYSIN; GRANZYME A; GRANZYME B; HOMING RECEPTOR; PERFORIN; TUMOR NECROSIS FACTOR ALPHA; CCR7 PROTEIN, HUMAN; CD28 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; CXCR3 PROTEIN, HUMAN; GNLY PROTEIN, HUMAN; GRANZYME; LIPOPOLYSACCHARIDE; T LYMPHOCYTE ANTIGEN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CD4+ CD25+ T LYMPHOCYTE; CELL CULTURE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ATHEROSCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; CORONARY ARTERY DISEASE; FEMALE; GRANZYMES; HUMANS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; PERFORIN; RECEPTORS, CCR7; RECEPTORS, CXCR3; RISK FACTORS; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

MLCS; MLOWN;

EID: 84873702376     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.01.007     Document Type: Article

References (34)

1. Hansson G.K., Libby P. The immune response in atherosclerosis: a double-edged sword. Nat. Rev. Immunol. 2006, 6:508-519.
2. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
3. Nakajima T., Goek O., Zhang X., Kopecky S.L., Frye R.L., Goronzy J.J., Weyand C.M. De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. Circ. Res. 2003, 93:106-113.
4. Nakajima T., Schulte S., Warrington K.J., Kopecky S.L., Frye R.L., Goronzy J.J., Weyand C.M. T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation 2002, 105:570-575.
5. Morishita Y., Sao H., Hansen J.A., Martin P.J. A distinct subset of human CD4+ cells with a limited alloreactive T cell receptor repertoire. J. Immunol. 1989, 143:2783-2789.
6. Snyder M.R., Nakajima T., Leibson P.J., Weyand C.M., Goronzy J.J. Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms. J. Immunol. 2004, 173:3725-3731.
7. Zal B., Kaski J.C., Arno G., Akiyu J.P., Xu Q., Cole D., Whelan M., Russell N., Madrigal J.A., Dodi I.A., Baboonian C. Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes. Circulation 2004, 109:1230-1235.
8. Namekawa T., Snyder M.R., Yen J.H., Goehring B.E., Leibson P.J., Weyand C.M., Goronzy J.J. Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. J. Immunol. 2000, 165:1138-1145.
9. Thewissen M., Somers V., Hellings N., Fraussen J., Damoiseaux J., Stinissen P. CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation. J. Immunol. 2007, 179:6514-6523.
10. Ramos-Casals M., Garcia-Carrasco M., Brito M.P., Lopez-Soto A., Font J. Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly. Lupus 2003, 12:341-355.
11. Helmersson J., Larsson A., Vessby B., Basu S. Active smoking and a history of smoking are associated with enhanced prostaglandin F(2alpha), interleukin-6 and F2-isoprostane formation in elderly men. Atherosclerosis 2005, 181:201-207.
12. Kurukulasuriya L.R., Stas S., Lastra G., Manrique C., Sowers J.R. Hypertension in obesity. Endocrinol. Metab. Clin. North Am. 2008, 37:647-662. ix.
13. Li J., Doerffel Y., Hocher B., Unger T. Inflammation in the genesis of hypertension and its complications - the role of angiotensin II. Nephrol. Dial. Transplant. 2007, 22:3107-3109.
14. Schieffer B., Luchtefeld M., Braun S., Hilfiker A., Hilfiker-Kleiner D., Drexler H. Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ. Res. 2000, 87:1195-1201.
15. Whaley-Connell A., Sowers J.R. Hypertension and insulin resistance. Hypertension 2009, 54:462-464.
16. Gerli R., Schillaci G., Giordano A., Bocci E.B., Bistoni O., Vaudo G., Marchesi S., Pirro M., Ragni F., Shoenfeld Y., Mannarino E. CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients. Circulation 2004, 109:2744-2748.
17. Liuzzo G., Biasucci L.M., Trotta G., Brugaletta S., Pinnelli M., Digianuario G., Rizzello V., Rebuzzi A.G., Rumi C., Maseri A., Crea F. Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events. J. Am. Coll. Cardiol. 2007, 50:1450-1458.
18. Liuzzo G., Kopecky S.L., Frye R.L., O'Fallon W.M., Maseri A., Goronzy J.J., Weyand C.M. Perturbation of the T-cell repertoire in patients with unstable angina. Circulation 1999, 100:2135-2139.
19. Rizzello V., Liuzzo G., Brugaletta S., Rebuzzi A., Biasucci L.M., Crea F. Modulation of CD4(+)CD28null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina. Circulation 2006, 113:2272-2277.
20. Suganami T., Nishida J., Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2062-2068.
21. Thewissen M., Somers V., Venken K., Linsen L., van Paassen P., Geusens P., Damoiseaux J., Stinissen P. Analyses of immunosenescent markers in patients with autoimmune disease. Clin. Immunol. 2007, 123:209-218.
22. Liuzzo G., Goronzy J.J., Yang H., Kopecky S.L., Holmes D.R., Frye R.L., Weyand C.M. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 2000, 101:2883-2888.
23. Kim Y.S., Ahn Y., Hong M.H., Kim K.H., Park H.W., Hong Y.J., Kim J.H., Kim W., Jeong M.H., Cho J.G., Park J.C., Kang J.C. Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and nuclear factor-kappaB in endothelial cells. J. Cardiovasc. Pharmacol. 2007, 49:376-383.
24. Rudich S.M., Mongini P.K., Perez R.V., Katznelson S. HMG-CoA reductase inhibitors pravastatin and simvastatin inhibit human B-lymphocyte activation. Transplant. Proc. 1998, 30:992-995.
25. Ulivieri C., Fanigliulo D., Benati D., Pasini F.L., Baldari C.T. Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation. Eur. J. Immunol. 2008, 38:2832-2844.
26. Brugaletta S., Biasucci L.M., Pinnelli M., Biondi-Zoccai G., Di Giannuario G., Trotta G., Liuzzo G., Crea F. Novel anti-inflammatory effect of statins: reduction of CD4+CD28null T lymphocyte frequency in patients with unstable angina. Heart 2006, 92:249-250.
27. Liuzzo G., Giubilato G., Pinnelli M. T cells and cytokines in atherogenesis. Lupus 2005, 14:732-735.
28. Ma L.L., Spurrell J.C., Wang J.F., Neely G.G., Epelman S., Krensky A.M., Mody C.H. CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15. J. Immunol. 2002, 169:5787-5795.
29. Ochoa M.T., Stenger S., Sieling P.A., Thoma-Uszynski S., Sabet S., Cho S., Krensky A.M., Rollinghoff M., Nunes Sarno E., Burdick A.E., Rea T.H., Modlin R.L. T-cell release of granulysin contributes to host defense in leprosy. Nat. Med. 2001, 7:174-179.
30. Stenger S., Hanson D.A., Teitelbaum R., Dewan P., Niazi K.R., Froelich C.J., Ganz T., Thoma-Uszynski S., Melian A., Bogdan C., Porcelli S.A., Bloom B.R., Krensky A.M., Modlin R.L. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 1998, 282:121-125.
31. Smeeth L., Thomas S.L., Hall A.J., Hubbard R., Farrington P., Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. N. Engl. J. Med. 2004, 351:2611-2618.
32. Wilcox J.N., Nelken N.A., Coughlin S.R., Gordon D., Schall T.J. Local expression of inflammatory cytokines in human atherosclerotic plaques. J. Atheroscler. Thromb. 1994, 1(Suppl. 1):S10-S13.
33. Mach F., Sauty A., Iarossi A.S., Sukhova G.K., Neote K., Libby P., Luster A.D. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells. J. Clin. Invest. 1999, 104:1041-1050.
34. Ridker P.M., Danielson E., Fonseca F.A., Genest J., Gotto A.M., Kastelein J.J., Koenig W., Libby P., Lorenzatti A.J., MacFadyen J.G., Nordestgaard B.G., Shepherd J., Willerson J.T., Glynn R.J. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 2008, 359:2195-2207.