Role of increased CD8/CD28 null T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease

Clinical and Experimental Immunology

Volumn 166, Issue 1, 2011, Pages 94-102

  Hodge, G ^a   Mukaro, V ^a   Reynolds, P N ^a   Hodge, S ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

CD8 CD28 null T cells; Co stimulatory molecules; COPD; Granzyme; Smoking mouse model

Indexed keywords

B7 ANTIGEN; CD134 ANTIGEN; CD28 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GRANZYME; OX40 LIGAND;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD4; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FLOW CYTOMETRY; GENE EXPRESSION; GRANZYMES; HUMANS; LUNG; LYMPHOCYTES, NULL; MICE; MIDDLE AGED; PERFORIN; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; UP-REGULATION;

EID: 80052614854     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04455.x     Document Type: Article

References (27)

1. Hodge S, Hodge G, Holmes M, Reynolds PN. Increased apoptosis in the airways in COPD persists after smoking cessation. Eur Respir J 2005; 25:447-54.
2. Eggleton P, Haigh R, Winyard PG. Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxf) 2008; 47:567-71.
3. Agustí A, MacNee W, Donaldson K, Cosio M. Hypothesis: does COPD have an autoimmune component? Thorax 2003; 58:832-4.
4. van der Strate BW, Postma DS, Brandsma CA etal. Cigarette smoke-induced emphysema: a role for the B cell? Am J Respir Crit Care Med 2006; 173:751-8.
5. Feghali-Bostwick CA, Gadgil AS, Otterbein LE etal. Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177:156-63.
6. Stefanska AM, Walsh PT. Chronic obstructive pulmonary disease: evidence for an autoimmune component. Cell Mol Immunol 2009; 6:81-6.
7. Lee SH, Goswami S, Grudo A etal. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 2007; 13:567-9.
8. Hodge G, Nairn J, Holmes M, Reynolds P, Hodge S. Increased intracellular T helper type 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of chronic obstructive pulmonary disease subjects. Clin Exp Immunol 2007; 150:22-9.
9. Saetta M, Di Stefano A, Turato G etal. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157:822-6.
10. Hodge SJ, Hodge GL, Reynolds PN, Scicchitano R, Holmes M. Increased production of TGF-beta and apoptosis of T lymphocytes isolated from peripheral blood in COPD. Am J Physiol Lung Cell Mol Physiol 2003; 285:L492-L499.
11. de Jong JW, van der Belt-Gritter B, Koeter GH, Postma DS. Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function. Respir Med 1997; 91:67-76.
12. Hodge S, Hodge G, Nairn J, Holmes M, Reynolds PN. Increased airway granzyme b and perforin in current and ex-smoking COPD subjects. COPD 2006; 3:1-9.
13. Guinan EC, Gribben JG, Bousiottis VA, Freeman GJ, Nadler LM. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood 1994; 84:3261-82.
14. (null) cells? Clin Exp Immunol 2010; 160:256-65.
15. Sharma G, Hanania NA, Shim YM. The aging immune system and its relationship to the development of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009; 6:573-80.
16. Arosa FA. CD8+CD28- T cells: certainties and uncertainties of a prevalent human T-cell subset. Immunol Cell Biol 2002; 80:1-13.
17. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001; 163:1256-76.
18. Hodge S, Matthews G, Dean M etal. Is there a therapeutic role for mannose binding lectin in cigarette smoke-induced lung inflammation? Evidence from a murine model. Am J Respir Cell Mol Biol 2010; 42:235-42.
19. Hodge S, Matthews G, Mukaro V etal. Cigarette smoke-induced changes to alveolar macrophage phenotype and function is improved by treatment with procysteine. Am J Respir Cell Mol Biol 2011; 44:673-81.
20. Hodge S, Hodge G, Flower R, Reynolds PN, Holmes M. Alveolar macrophages from subjects with COPD are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol 2003; 81:289-96.
21. Hodge S, Hodge G, Ahern J, Jersman H, Holmes M, Reynolds PN. Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2007; 37:748-55.
22. Lambers C, Hacker S, Posch M etal. T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease. Clin Exp Immunol 2009; 155:466-75.
23. Roberts SD, Kohli LL, Wood KL, Wilkes DS, Knox KS. CD4+CD28-T cells are expanded in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2005; 22:13-19.
24. Katchar K, Wahlström J, Eklund A, Grunewald J. Highly activated T-cell receptor AV2S3(+) CD4(+) lung T-cell expansions in pulmonary sarcoidosis. Am J Respir Crit Care Med 2001; 163:1540-5.
25. Wouters EF. Chronic obstructive pulmonary disease. 5: Systemic effects of COPD. Thorax 2002; 57:1067-70.
26. Oudijk EJ, Lammers JW, Koenderman L. Systemic inflammation in chronic obstructive pulmonary disease. Eur Respir J Suppl 2003; 46:5s-13s.
27. Lehmann C, Wilkening A, Leiber D etal. Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system. Anat Rec 2001; 264:229-36.