Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: Novel potential treatment for COPD

BMC Pulmonary Medicine

Volumn 14, Issue 1, 2014, Pages

  Hodge, Greg ^a,b   Holmes, Mark ^a,b   Jersmann, Hubertus ^a,b   Reynolds, Paul N ^a,b   Hodge, Sandra ^a,b  

^a Department of Neurosurgery   (South Africa)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Blocking CD137; CD28null T and NKT like cells; COPD; IFN and TNF ; NK cells

Indexed keywords

CD137 ANTIGEN; CD28 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANZYME B; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC LYMPHOCYTE; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MALE; NATURAL KILLER CELL; NATURAL KILLER T CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; UPREGULATION; BLOOD; CASE CONTROL STUDY; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LYMPHOCYTE; MOLECULARLY TARGETED THERAPY; MONONUCLEAR CELL; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

ANTIGENS, CD137; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MALE; MOLECULAR TARGETED THERAPY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84902553477     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-14-85     Document Type: Article

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