A micelle-like structure of poloxamer-methotrexate conjugates as nanocarrier for methotrexate delivery

International Journal of Pharmaceutics

Volumn 487, Issue 1-2, 2015, Pages 177-186

  Ren, Jin ^a,b   Fang, Zhengjie ^a   Yao, Li ^c   Dahmani, Fatima Zohra ^a   Yin, Lifang ^a   Zhou, Jianping ^a   Yao, Jing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

^c Department of Endocrinology   (China)

Author keywords

Bioavailability; Biphasic release; Micelles; MTX; Poloxamer

Indexed keywords

METHOTREXATE; NANOCARRIER; POLOXAMER; ANTIMETABOLITE; DELAYED RELEASE FORMULATION; DRUG CARRIER; ESTER; MICELLE; NANOPARTICLE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ESTERIFICATION; HYDROGEN BOND; HYDROPHOBICITY; IN VIVO STUDY; MALE; MEAN RESIDENCE TIME; MOLECULAR WEIGHT; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SUSTAINED DRUG RELEASE; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG FORMULATION; MICELLE; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIMETABOLITES; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ESTERS; MALE; METHOTREXATE; MICELLES; NANOPARTICLES; PARTICLE SIZE; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84927728767     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.04.014     Document Type: Article

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