pH-responsive polymeric micelles of poly(ethylene glycol)-b-poly(alkyl(meth)acrylate-co-methacrylic acid): Influence of the copolymer composition on self-assembling properties and release of candesartan cilexetil

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 65, Issue 3, 2007, Pages 379-387

  Satturwar, Prashant ^a   Eddine, Mohamad Nasser ^a   Ravenelle, François ^b   Leroux, Jean Christophe ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Labopharm Inc   (Canada)

Author keywords

Atom transfer radical polymerization; Candesartan cilexetil; Critical aggregation concentration; Drug solubilization; Oral delivery; pH sensitivity; Poly(ethylene glycol) b poly(alkyl(meth)acrylate co methacrylic acid); Polymeric micelles; Solvent evaporation

Indexed keywords

ACRYLIC ACID BUTYL ESTER; ACRYLIC ACID ISOBUTYL ESTER; CANDESARTAN HEXETIL; COPOLYMER; MACROGOL; METHACRYLIC ACID TERT BUTYL ESTER; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; ATOMIC FORCE MICROSCOPY; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; EVALUATION; EVAPORATION; HYDROLYSIS; IMAGE ANALYSIS; LIGHT SCATTERING; MICELLE; PARTICLE SIZE; PKA; SOLUBILITY; STRUCTURE ANALYSIS; SYNTHESIS;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; GASTRIC JUICE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIGHT; METHACRYLATES; MICELLES; MICROSCOPY, ATOMIC FORCE; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; SCATTERING, RADIATION; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TETRAZOLES; TIME FACTORS; WATER;

EID: 33847337418     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.09.012     Document Type: Article

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