Evaluation of a repeated dose liver micronucleus assay in rats treated with two genotoxic hepatocarcinogens, dimethylnitrosamine and 2-acetylaminofluorene: The possibility of integrating micronucleus tests with multiple tissues into a repeated dose general toxicity study

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 780-781, Issue , 2015, Pages 18-24

  Takashima, Rie ^a   Takasawa, Hironao ^a   Kawasako, Kazufumi ^a   Ohyama, Wakako ^b   Okada, Emiko ^b   Narumi, Kazunori ^b   Fujiishi, Yohei ^b   Wako, Yumi ^a   Yasunaga, Katsuaki ^a   Hattori, Akiko ^a   Kawabata, Masayoshi ^a   Nakadate, Kiyoko ^a   Nakagawa, Munehiro ^a   Hamada, Shuichi ^a  

^a LSI MEDIENCE CORPORATION   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Genotoxic hepatocarcinogens; GI tract micronucleus assay; Integration into toxicity study; Liver micronucleus assay; Repeated dosing

Indexed keywords

DIMETHYLNITROSAMINE; N (2 FLUORENYL)ACETAMIDE; CARCINOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENOTOXICITY; INFLAMMATORY CELL; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DOSE LIVER MICRONUCLEUS ASSAY; WEIGHT CHANGE; ANIMAL; ANTIBODY SPECIFICITY; BONE MARROW; CHROMOSOME ABERRATION; COOPERATION; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; GASTROINTESTINAL TRACT; HEALTH CARE ORGANIZATION; HUMAN; JAPAN; LIVER; LIVER CELL; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ANIMALIA; MAMMALIA; RATTUS;

2-ACETYLAMINOFLUORENE; ADMINISTRATION, ORAL; ANIMALS; BONE MARROW; CARCINOGENS; CHROMOSOME ABERRATIONS; COOPERATIVE BEHAVIOR; DIMETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GASTROINTESTINAL TRACT; HEPATOCYTES; HUMANS; JAPAN; LIVER; MALE; MICRONUCLEUS TESTS; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, PHARMACEUTICAL;

EID: 84927711610     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.10.007     Document Type: Article

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