메뉴 건너뛰기




Volumn 27, Issue 23, 2008, Pages 3313-3328

Orphan nuclear receptor estrogen-related receptor-β suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer

Author keywords

ERR ; Estrogen receptor related receptor; Estrogen related receptor; Orphan nuclear receptor; Prostate cancer; Tumor suppression

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; ESTROGEN RELATED RECEPTOR ALPHA; ESTROGEN RELATED RECEPTOR BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

EID: 44349192262     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210986     Document Type: Article
Times cited : (68)

References (45)
  • 1
    • 33747154772 scopus 로고    scopus 로고
    • Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
    • Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. (2006). Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126: 789-799.
    • (2006) Cell , vol.126 , pp. 789-799
    • Bookout, A.L.1    Jeong, Y.2    Downes, M.3    Yu, R.T.4    Evans, R.M.5    Mangelsdorf, D.J.6
  • 2
    • 33746086158 scopus 로고    scopus 로고
    • Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes
    • Castet A, Herledan A, Bonnet S, Jalaguier S, Vanacker JM, Cavaillès V. (2006). Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol Endocrinol 20: 1035-1047.
    • (2006) Mol Endocrinol , vol.20 , pp. 1035-1047
    • Castet, A.1    Herledan, A.2    Bonnet, S.3    Jalaguier, S.4    Vanacker, J.M.5    Cavaillès, V.6
  • 3
    • 0032858242 scopus 로고    scopus 로고
    • In situ hybridization study of PSP94 (prostatic secretory protein of 94 amino acids) expression in human prostates
    • Chan PS, Chan LW, Xuan JW, Chin JL, Choi HL, Chan FL. (1999). In situ hybridization study of PSP94 (prostatic secretory protein of 94 amino acids) expression in human prostates. Prostate 41: 99-109.
    • (1999) Prostate , vol.41 , pp. 99-109
    • Chan, P.S.1    Chan, L.W.2    Xuan, J.W.3    Chin, J.L.4    Choi, H.L.5    Chan, F.L.6
  • 4
    • 0033522229 scopus 로고    scopus 로고
    • Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR
    • Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C et al. (1999). Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene 228: 101-109.
    • (1999) Gene , vol.228 , pp. 101-109
    • Chen, F.1    Zhang, Q.2    McDonald, T.3    Davidoff, M.J.4    Bailey, W.5    Bai, C.6
  • 5
    • 15944404288 scopus 로고    scopus 로고
    • Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues
    • Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X et al. (2005). Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues. J Clin Endocrinol Metab 90: 1830-1844.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1830-1844
    • Cheung, C.P.1    Yu, S.2    Wong, K.B.3    Chan, L.W.4    Lai, F.M.5    Wang, X.6
  • 7
    • 0036633114 scopus 로고    scopus 로고
    • To ERR in the estrogen pathway
    • Giguère V. (2002). To ERR in the estrogen pathway. Trends Endocrinol Metab 13: 220-225.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 220-225
    • Giguère, V.1
  • 8
    • 0023857147 scopus 로고
    • Identification of a new class of steroid hormone receptors
    • Giguère V, Yang N, Segui P, Evans RM. (1988). Identification of a new class of steroid hormone receptors. Nature 331: 91-94.
    • (1988) Nature , vol.331 , pp. 91-94
    • Giguère, V.1    Yang, N.2    Segui, P.3    Evans, R.M.4
  • 9
    • 0033814734 scopus 로고    scopus 로고
    • Estrogens and prostatic disease. International Prostate Health Council Study Group
    • Griffiths K. (2000). Estrogens and prostatic disease. International Prostate Health Council Study Group. Prostate 45: 87-100.
    • (2000) Prostate , vol.45 , pp. 87-100
    • Griffiths, K.1
  • 10
    • 3042601089 scopus 로고    scopus 로고
    • Dietary influences on endocrine-inflammatory interactions in prostate cancer development
    • Ho E, Boileau TW, Bray TM. (2004). Dietary influences on endocrine-inflammatory interactions in prostate cancer development. Arch Biochem Biophys 428: 109-117.
    • (2004) Arch Biochem Biophys , vol.428 , pp. 109-117
    • Ho, E.1    Boileau, T.W.2    Bray, T.M.3
  • 11
    • 3843145374 scopus 로고    scopus 로고
    • Estrogens and anti-estrogens: Key mediators of prostate carcinogenesis and new therapeutic candidates
    • Ho SM. (2004). Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates. J Cell Biochem 91: 491-503.
    • (2004) J Cell Biochem , vol.91 , pp. 491-503
    • Ho, S.M.1
  • 12
    • 28144452372 scopus 로고    scopus 로고
    • HZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes
    • Huang CY, Beliakoff J, Li X, Lee J, Li X, Sharma M et al. (2005). HZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol Endocrinol 19: 2915-2929.
    • (2005) Mol Endocrinol , vol.19 , pp. 2915-2929
    • Huang, C.Y.1    Beliakoff, J.2    Li, X.3    Lee, J.4    Li, X.5    Sharma, M.6
  • 13
    • 0037174798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ
    • Huss JM, Kopp RP, Kelly DP. (2002). Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ. J Biol Chem 277: 40265-40274.
    • (2002) J Biol Chem , vol.277 , pp. 40265-40274
    • Huss, J.M.1    Kopp, R.P.2    Kelly, D.P.3
  • 14
    • 4744371376 scopus 로고    scopus 로고
    • Estrogen-related receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    • Huss JM, Torra IP, Staels B, Giguère V, Kelly DP. (2004). Estrogen-related receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol 24: 9079-9091.
    • (2004) Mol Cell Biol , vol.24 , pp. 9079-9091
    • Huss, J.M.1    Torra, I.P.2    Staels, B.3    Giguère, V.4    Kelly, D.P.5
  • 15
    • 0037185003 scopus 로고    scopus 로고
    • Identification of a specific molecular repressor of the peroxisome proliferator-activator receptor γ coactivator-1α (PGC-1α)
    • Ichida M, Nemoto S, Finkel T. (2002). Identification of a specific molecular repressor of the peroxisome proliferator-activator receptor γ coactivator-1α (PGC-1α). J Biol Chem 277: 50991-50995.
    • (2002) J Biol Chem , vol.277 , pp. 50991-50995
    • Ichida, M.1    Nemoto, S.2    Finkel, T.3
  • 16
    • 0142091356 scopus 로고    scopus 로고
    • PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity
    • Kamei Y, Ohizumi H, Fujitani Y, Nemoto T, Tanaka T, Takahashi N et al. (2003). PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci USA 100: 12378-12383.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12378-12383
    • Kamei, Y.1    Ohizumi, H.2    Fujitani, Y.3    Nemoto, T.4    Tanaka, T.5    Takahashi, N.6
  • 17
    • 33750034898 scopus 로고    scopus 로고
    • Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells
    • Litvinov IV, Griend DJ, Antony L, Dalrymple S, De Marzo AM, Drake CG et al. (2006). Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells. Proc Natl Acad Sci USA 103: 15085-15090.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15085-15090
    • Litvinov, I.V.1    Griend, D.J.2    Antony, L.3    Dalrymple, S.4    De Marzo, A.M.5    Drake, C.G.6
  • 18
    • 33748260777 scopus 로고    scopus 로고
    • Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
    • Liu Y. (2006). Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis 9: 230-234.
    • (2006) Prostate Cancer Prostatic Dis , vol.9 , pp. 230-234
    • Liu, Y.1
  • 19
    • 0035883862 scopus 로고    scopus 로고
    • Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors
    • Lu D, Kiriyama Y, Lee KY, Giguère V. (2001). Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors. Cancer Res 61: 6755-6761.
    • (2001) Cancer Res , vol.61 , pp. 6755-6761
    • Lu, D.1    Kiriyama, Y.2    Lee, K.Y.3    Giguère, V.4
  • 20
    • 33750489759 scopus 로고    scopus 로고
    • Molecular cloning and functional study of rat estrogen receptor-related receptor γ in rat prostatic cells
    • Lui K, Huang Y, Choi HL, Yu S, Wong KB, Chen S et al. (2006). Molecular cloning and functional study of rat estrogen receptor-related receptor γ in rat prostatic cells. Prostate 66: 1600-1619.
    • (2006) Prostate , vol.66 , pp. 1600-1619
    • Lui, K.1    Huang, Y.2    Choi, H.L.3    Yu, S.4    Wong, K.B.5    Chen, S.6
  • 21
    • 0030869565 scopus 로고    scopus 로고
    • Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β
    • Luo J, Sladek R, Bader JA, Matthyssen A, Rossant J, Giguère V. (1997). Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β. Nature 388: 778-782.
    • (1997) Nature , vol.388 , pp. 778-782
    • Luo, J.1    Sladek, R.2    Bader, J.A.3    Matthyssen, A.4    Rossant, J.5    Giguère, V.6
  • 22
    • 0242580188 scopus 로고    scopus 로고
    • Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α
    • Luo J, Sladek R, Carrier J, Bader JA, Richard D, Giguère V. (2003). Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α. Mol Cell Biol 23: 7947-7956.
    • (2003) Mol Cell Biol , vol.23 , pp. 7947-7956
    • Luo, J.1    Sladek, R.2    Carrier, J.3    Bader, J.A.4    Richard, D.5    Giguère, V.6
  • 23
    • 1442299168 scopus 로고    scopus 로고
    • Loss of PGC-specific expression of the orphan nuclear receptor ERR-β results in reduction of germ cell number in mouse embryos
    • Mitsunaga K, Araki K, Mizusaki H, Morohashi K, Haruna K, Nakagata N et al. (2004). Loss of PGC-specific expression of the orphan nuclear receptor ERR-β results in reduction of germ cell number in mouse embryos. Mech Dev 121: 237-246.
    • (2004) Mech Dev , vol.121 , pp. 237-246
    • Mitsunaga, K.1    Araki, K.2    Mizusaki, H.3    Morohashi, K.4    Haruna, K.5    Nakagata, N.6
  • 24
    • 0030062628 scopus 로고    scopus 로고
    • Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis
    • Pettersson K, Svensson K, Mattsson R, Carlsson B, Ohlsson R, Berkenstam A. (1996). Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev 54: 211-223.
    • (1996) Mech Dev , vol.54 , pp. 211-223
    • Pettersson, K.1    Svensson, K.2    Mattsson, R.3    Carlsson, B.4    Ohlsson, R.5    Berkenstam, A.6
  • 25
    • 33847790692 scopus 로고    scopus 로고
    • The role of estrogens in normal and abnormal development of the prostate gland
    • Prins GS, Huang L, Birch L, Pu Y. (2006). The role of estrogens in normal and abnormal development of the prostate gland. Ann N Y Acad Sci 1089: 1-13.
    • (2006) Ann N Y Acad Sci , vol.1089 , pp. 1-13
    • Prins, G.S.1    Huang, L.2    Birch, L.3    Pu, Y.4
  • 26
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activator receptor-γ coactivator 1α (PGC-1α): Transcriptional coactivator and metabolic regulator
    • Puigserver P, Spiegelman BM. (2003). Peroxisome proliferator-activator receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24: 78-90.
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 27
    • 2342592545 scopus 로고    scopus 로고
    • The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
    • Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M et al. (2004). The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 101: 6472-6477.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6472-6477
    • Schreiber, S.N.1    Emter, R.2    Hock, M.B.3    Knutti, D.4    Cardenas, J.5    Podvinec, M.6
  • 28
    • 0344874663 scopus 로고    scopus 로고
    • HZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci
    • Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ et al. (2003). HZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBL J 22: 6101-6114.
    • (2003) EMBL J , vol.22 , pp. 6101-6114
    • Sharma, M.1    Li, X.2    Wang, Y.3    Zarnegar, M.4    Huang, C.Y.5    Palvimo, J.J.6
  • 29
    • 0030787844 scopus 로고    scopus 로고
    • The orphan nuclear receptor estrogen-related receptor α is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene
    • Sladek R, Bader JA, Giguére V. (1997). The orphan nuclear receptor estrogen-related receptor α is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol 17: 5400-5409.
    • (1997) Mol Cell Biol , vol.17 , pp. 5400-5409
    • Sladek, R.1    Bader, J.A.2    Giguére, V.3
  • 30
    • 33748314528 scopus 로고    scopus 로고
    • Evidence for a mitochondrial regulatory pathway defined peroxisome proliferator-activated receptor-γ coactivator-1α, estrogen-related receptor-α, and mitofusin 2
    • Soriano FX, Liesa M, Bach D, Chan DC, Palacín M, Zorzano A. (2006). Evidence for a mitochondrial regulatory pathway defined peroxisome proliferator-activated receptor-γ coactivator-1α, estrogen-related receptor-α, and mitofusin 2. Diabetes 55: 1783-1791.
    • (2006) Diabetes , vol.55 , pp. 1783-1791
    • Soriano, F.X.1    Liesa, M.2    Bach, D.3    Chan, D.C.4    Palacín, M.5    Zorzano, A.6
  • 31
  • 33
    • 0029985338 scopus 로고    scopus 로고
    • Nuclear orphan receptor as a repressor of glucocorticoid receptor transcriptional activity
    • Trapp T, Holsboer F. (1996). Nuclear orphan receptor as a repressor of glucocorticoid receptor transcriptional activity. J Biol Chem 271: 9879-9882.
    • (1996) J Biol Chem , vol.271 , pp. 9879-9882
    • Trapp, T.1    Holsboer, F.2
  • 34
    • 0033517107 scopus 로고    scopus 로고
    • Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ
    • Vanacker JM, Pettersson K, Gustafsson JÅ, Laudet V. (1999). Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ. EMBO J 18: 4270-4279.
    • (1999) EMBO J , vol.18 , pp. 4270-4279
    • Vanacker, J.M.1    Pettersson, K.2    Gustafsson, J.Å.3    Laudet, V.4
  • 35
    • 24944584210 scopus 로고    scopus 로고
    • Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: Role of fatty acid β-oxidation and glucose
    • Vankoningsloo S, Piens M, Lecocq C, Gilson A, De Pauw A, Renard P et al. (2005). Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid β-oxidation and glucose. J Lipid Res 46: 1133-1149.
    • (2005) J Lipid Res , vol.46 , pp. 1133-1149
    • Vankoningsloo, S.1    Piens, M.2    Lecocq, C.3    Gilson, A.4    De Pauw, A.5    Renard, P.6
  • 37
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga S, Hannon GJ, Beach D, Stillman B. (1994). The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 38
    • 28544438180 scopus 로고    scopus 로고
    • PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: A mechanism for transcriptional control of muscle glucose metabolism
    • Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP. (2005). PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 25: 10684-10694.
    • (2005) Mol Cell Biol , vol.25 , pp. 10684-10694
    • Wende, A.R.1    Huss, J.M.2    Schaeffer, P.J.3    Giguère, V.4    Kelly, D.P.5
  • 40
    • 0041833727 scopus 로고    scopus 로고
    • Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells
    • Wright ME, Tsai MJ, Aebersold R. (2003). Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells. Mol Endocrinol 17: 1726-1737.
    • (2003) Mol Endocrinol , vol.17 , pp. 1726-1737
    • Wright, M.E.1    Tsai, M.J.2    Aebersold, R.3
  • 41
    • 0033345059 scopus 로고    scopus 로고
    • Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2
    • Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR et al. (1999). Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. Mol Endocrinol 13: 2151-2162.
    • (1999) Mol Endocrinol , vol.13 , pp. 2151-2162
    • Xie, W.1    Hong, H.2    Yang, N.N.3    Lin, R.J.4    Simon, C.M.5    Stallcup, M.R.6
  • 42
    • 33747157406 scopus 로고    scopus 로고
    • Nuclear receptor expression links the circadian clock to metabolism
    • Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M et al. (2006). Nuclear receptor expression links the circadian clock to metabolism. Cell 126: 801-810.
    • (2006) Cell , vol.126 , pp. 801-810
    • Yang, X.1    Downes, M.2    Yu, R.T.3    Bookout, A.L.4    He, W.5    Straume, M.6
  • 43
    • 13944270955 scopus 로고    scopus 로고
    • Identification of an agonist ligand for estrogen-related receptors ERRβ/γ
    • Yu DD, Forman BM. (2005). Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg Med Chem Lett 15: 1311-1313.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 1311-1313
    • Yu, D.D.1    Forman, B.M.2
  • 44
    • 34250371424 scopus 로고    scopus 로고
    • ERRγ suppresses cell proliferation and tumor growth androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer
    • Yu S, Wang X, Ng CF, Chen S, Chan FL. (2007). ERRγ suppresses cell proliferation and tumor growth androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res 67: 4904-4914.
    • (2007) Cancer Res , vol.67 , pp. 4904-4914
    • Yu, S.1    Wang, X.2    Ng, C.F.3    Chen, S.4    Chan, F.L.5
  • 45
    • 32544441388 scopus 로고    scopus 로고
    • Identification and characterization of two novel splicing isoforms of human estrogen-related receptor β
    • Zhou W, Liu Z, Wu J, Liu J, Hyder SM, Antoniou E et al. (2006). Identification and characterization of two novel splicing isoforms of human estrogen-related receptor β. J Clin Endocrinol Metab 91: 569-579.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 569-579
    • Zhou, W.1    Liu, Z.2    Wu, J.3    Liu, J.4    Hyder, S.M.5    Antoniou, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.