SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth

EMBO Journal

Volumn 34, Issue 8, 2015, Pages 1110-1125

  Yang, Hui ^a   Zhou, Lisha ^a   Shi, Qian ^a   Zhao, Yuzheng ^b   Lin, Huaipeng ^a   Zhang, Mengli ^a   Zhao, Shimin ^a   Yang, Yi ^b   Ling, Zhi Qiang ^c   Guan, Kun Liang ^a,d   Xiong, Yue ^a,e   Ye, Dan ^a  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY   (China)

^c ZHEJIANG CANCER HOSPITAL   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

acetylation; GOT2; malate aspartate NADH shuttle; pancreatic cancer

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASPARTATE AMINOTRANSFERASE ISOENZYME 2; ASPARTIC ACID; LYSINE; MALATE DEHYDROGENASE; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 3; MALIC ACID DERIVATIVE; SIRT3 PROTEIN, HUMAN;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PANCREAS CANCER; PANCREAS CELL; PRIORITY JOURNAL; TUMOR GROWTH; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; HEK293 CELL LINE; METABOLISM; NUDE MOUSE; OXIDATION REDUCTION REACTION; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; TRANSPORT AT THE CELLULAR LEVEL;

ACETYLATION; ANIMALS; ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL; ASPARTIC ACID; BIOLOGICAL TRANSPORT; CARCINOMA, PANCREATIC DUCTAL; CELL PROLIFERATION; CELLS, CULTURED; HEK293 CELLS; HUMANS; MALATES; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; NAD; OXIDATION-REDUCTION; PANCREATIC NEOPLASMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIRTUIN 3;

EID: 84927698067     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591041     Document Type: Article

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