Non-invasive in-cell determination of free cytosolic [NAD+]/ [NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes

Journal of Biological Chemistry

Volumn 289, Issue 4, 2014, Pages 2344-2352

  Christensen, Caspar Elo ^a,b   Karlsson, Magnus ^a   Winther, Jakob R ^b   Jensen, Pernille Rose ^a   Lerche, Mathilde H ^a  

^a Albeda Research   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CELL TYPES; CELLULAR REDOX; CYTOSOLIC; HYPERPOLARIZED; METABOLIC PHENOTYPE; PHENOTYPING; PYRUVATES; WIDE SELECTION;

GLUCOSE;

METABOLISM;

1 CARBON LACTATE C 13; 1 CARBON PYRUVIC ACID C 13; GLUCOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PENTOSE PHOSPHATE; RADIOISOTOPE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL KINETICS; CELL METABOLISM; CONTROLLED STUDY; FREE CYTOSOLIC NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE RATIO; GLYCOLYSIS; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERPOLARIZATION; LACTATE PYRUVATE RATIO; MALE; METABOLIC PARAMETERS; METABOLITE; NON INVASIVE PROCEDURE; OXIDATION REDUCTION STATE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER;

BREAST CANCER; GLUCOSE; HYPERPOLARIZATION; METABOLIC PHENOTYPE; NAD; NADH; PROSTATE CANCER;

BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GLUCOSE; GLYCOLYSIS; HUMANS; LACTIC ACID; MALE; NAD; PROSTATIC NEOPLASMS; PYRUVIC ACID;

EID: 84893109709     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.498626     Document Type: Article

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