NQO1 protein expression predicts poor prognosis of non-small cell lung cancers

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Li, Zhenling ^a   Zhang, Yue ^b   Jin, Tiefeng ^a   Men, Jiguang ^a   Lin, Zhenhua ^a   Qi, Peng ^a   Piao, Yingshi ^a   Yan, Guanghai ^a  

^a YANBIAN UNIVERSITY MEDICAL COLLEGE   (China)

^b JILIN CANCER HOSPITAL   (China)

Author keywords

Immunohistochemistry; Non small cell lung cancer; NQO1; Prognosis; Survival analysis

Indexed keywords

NQO1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TUMOR MARKER; UNCLASSIFIED DRUG; NQO1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; PREDICTIVE VALUE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SQUAMOUS CELL LUNG CARCINOMA; SURVIVAL PREDICTION; SURVIVAL RATE; TUMOR DIFFERENTIATION; TUMOR VOLUME; UPREGULATION; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; PATHOLOGY; PROGNOSIS;

ADULT; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NAD(P)H DEHYDROGENASE (QUINONE); NEOPLASM STAGING; PROGNOSIS;

EID: 84927642915     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1227-8     Document Type: Article

References (35)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30.
2. Chen X, Liu Y, Røe OD, Qian Y, Guo R, Zhu L, et al. Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: a systematic review. PLoS One. 2013;8(3):e59314.
3. Gaughan EM, Costa DB. Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities. Ther Adv Med Oncol. 2011;3(3):113-25.
4. Jin T, Jin J, Shang Y, Zhang S, Yu K, Piao Y, et al. Prognostic implications of ezrin and phosphorylated ezrin expression in non-small cell lung cancer. BMC Cancer. 2014;14:191.
5. Vasilious V, Rose D, Nebert DW. Update of the NAD(P)H: quinone oxidoreductase (NQO) gene family. Hum Genomic. 2006;2(5):329-35.
6. Buranrat B, Prawan A, Kukongviriyapan U, Kongpetch S, Kukongviriyapan V. Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells. World J Gastroenterol. 2010;16(19):2362-70.
7. Siegel D, Gustafson DL, Dehn DL, Han JY, Boonchoong P, Berliner LJ, et al. NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavengar. Mol Pharmacol. 2004;65(5):1238-47.
8. Siegel D, Bolton EM, Burr JA, Liebler DC, Ross D. The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydrolquinone as a cellular antioxidant. Mol Pharmacol. 1997;52(2):300-5.
9. Siegel D, Ross D. Immunodetection of NAD(P)H: quinone oxidoreductase 1 (NQO1) in human tissues. Free RadicBiol Med. 2000;29(2-3):246-53.
10. Chao C, Zhang ZF, Berthiller J, Boffetta P, Hashibe M. NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15(5):979-87.
11. Awadallah NS, Dehn D, Shah RJ, Russell Nash S, Chen YK, Ross D, et al. NQO1 expression in pancreatic cancer and its potentail use as a biomarker. ApplImmunohistochem Mol Morphol. 2008;16(1):24-31.
12. Buranrat B, Chau-in S, Prawan A, Puapaoroj A, Zeekpudsa P, Kukongviriyapan V. NQO1 expression correlates with cholangiocarcinoma prognosis. Asian Pac J Cancer Pre. 2012;13(Suppl):131-6.
13. Garate M, Wani AA, Li G. The NAD(P)H:Quinone Oxidoreductase 1 inducescell cycle progression and proliferation of melanoma cells. Free RadicBiolMed. 2010;48(12):1601-9.
14. Ernster L, Lindberg O. Animal mitochondria. Annu Rev Physiol. 1958;20:13-42.
15. Nioi P, Hayes JD. Contribution of NAD(P)H: quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res. 2004;555(1-2):149-71.
16. Girolami F, Abbadessa G, Racca S, Spaccamiglio A, Piccione F, Dacasto M, et al. Time-dependent acetylsalicylic acid effects on liver CYP1A and antioxidant enzymes in a rat model of 7,12-dimethylbenzanthracene(DMBA)-induced mammary carcinogenesis. Toxicol Lett. 2008;181(2):87-92.
17. Nagata M, Kimura T, Suzumura T, Kira Y, Nakai T, Umekawa K, et al. C609Tpolymorphism of NADPH Quinone Oxidoreductase 1 Correlates clinicalhematological toxicities in lung cancer patients treated with Amrubicin. Clin Med Insights Oncol. 2013;7:31-9.
18. Malik MA, Zargar SA, Mittal B. Role of NQO1 609C > T and NQO2-3423G > A gene polymorphisms in esophageal cancer risk in Kashmir valley andmeta analysis. Mol Biol Rep. 2012;39(9):9095-104.
19. Fagerholm R, Hofstetter B, Tommiska J, Aaltonen K, Vrtel R, Syrjäkoski K, et al. NAD(P)H: quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet. 2008;40(7):844-53.
20. Asher G, Lotem J, Cohen B, Sachs L, Shaul Y. Regulation of p53 stability and p53-dependent apoptosis by NADH quinoneoxidoreductase 1. Proc NatlAcadSci U S A. 2001;98(3):1188-93.
21. Asher G, Bercovich Z, Tsvetkov P, Shaul Y, Kahana C. 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1. Mol Cell. 2005;17(5):645-55.
22. Yang Y, Zhang Y, Wu Q, Cui X, Lin Z, Liu S, et al. Clinical implications of high NQO1 expression inbreast cancers. J Exp Clin Cancer Res. 2014;33:14.
23. Ma Y, Kong J, Yan G, Ren X, Jin D, Jin T, et al. NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix. BMC Cancer. 2014;14:414.
24. Lin L, Qin Y, Jin T, Liu S, Zhang S, Shen X, et al. Significance of NQO1overexpression for prognostic evaluation of gastric adenocarcinoma. Exp Mol Pathol. 2014;96(2):200-5.
25. Awadallah NS, Dehn D, Shah RJ, Russell Nash S, Chen YK, Ross D, et al. NQO1 expression in pancreatic cancer and its potential use as a biomarker. Appl Immunohistochem Mol Morphol. 2008;16(1):24-31.
26. Lyn-Cook BD, Yan-Sanders Y, Moore S, Taylor S, Word B, Hammons GJ. Increased levels of NAD(P)H: quinoneoxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas. Cell Biol Toxicol. 2006;22(2):73-80.
27. Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, et al. Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl. Cancer Res. 1992;52(17):4752-7.
28. Rosvold EA, McGlynn KA, Lustbader ED, Buetow KH. Identification of an NAD(P)H: quinone oxidoreductase polymorphism and its association with lung cancer and smoking. Pharmacogenetics. 1995;5(4):199-206.
29. Heller G, Zielinski CC, Zochbauer-Muller S. Lung cancer: from single-gene methylation to methylome profiling. Cancer Metastasis Rev. 2010;29(1):95-107.
30. Mikami K, Naito M, Ishiguro T, Yano H, Tomida A, Yamada T, et al. Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase. Jpn J Cancer Res. 1998;89(9):910-5.
31. Kim HC, Song JS, Lee JC, Lee DH, Kim SW, Lee JS, et al. Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer. Int J Clin Exp Pathol. 2014;7(10):6743-51.
32. Workman P. Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol Res. 1994;6(10-11):461-75.
33. Park EJ, Min KJ, Lee TJ, Yoo YH, Kim YS, Kwon TK. β-Lapachoneindcuces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells. Cell Death Dis. 2014;5:e1230.
34. Kung H, Weng T, Liu Y, Lu K, Chau Y. Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells. PLoS One. 2014;9(2):e88122.
35. Huang X, Dong Y, Bey E. An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis. Cancer Res. 2012;72(12):3038-47.