NOTCH mutations: Multiple faces in human malignancies

Cancer Prevention Research

Volumn 8, Issue 4, 2015, Pages 259-261

  Mao, Li ^a  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PRESENILIN 1; PROTEIN P53; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B LYMPHOCYTE ACTIVATION; BILE DUCT CARCINOMA; CANCER PATIENT; CARCINOGENESIS; CAUCASIAN; CHROMOSOME TRANSLOCATION; CHRONIC LYMPHATIC LEUKEMIA; COHORT ANALYSIS; COLORECTAL CARCINOMA; FOLLOW UP; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; HAN CHINESE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HEMATOPOIETIC SYSTEM TUMOR; HUMAN; LEUKOPLAKIA; LOSS OF FUNCTION MUTATION; LUNG ADENOCARCINOMA; LYMPHOMA; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; MELANOMA; MOUTH SQUAMOUS CELL CARCINOMA; MULTIPLE CANCER; MUTATION; MUTATION RATE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOLID TUMOR; SOMATIC MUTATION; CELL TRANSFORMATION; GENETICS; METABOLISM; MOUTH MUCOSA; MOUTH TUMOR; PATHOLOGY; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; LEUKOPLAKIA, ORAL; MOUTH MUCOSA; MOUTH NEOPLASMS; MUTATION; RECEPTOR, NOTCH1;

EID: 84927583302     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-15-0063     Document Type: Article

References (30)

1. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S. Specific EGF repeats of notch mediate interactions with delta and serrate: Implications for Notch as a multifunctional receptor. Cell 1991;67: 687-99.
2. Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, et al. Nicastrin functions as a gamma-secretase-substrate receptor. Cell 2005;122:435-47.
3. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligandinduced proteolytic release of intracellular domain. Nature 1998;393: 382-6.
4. Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006;7:678-89.
5. Ntziachristos P, Lim JS, Sage J, Aifantis I. From fly wings to targeted cancer therapies: a centennial for Notch signaling. Cancer Cell 2014;25:318-34.
6. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66:649-61.
7. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol 1997;17:6265-73.
8. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996;183:2283-91.
9. Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71.
10. Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 2011;208:1389-401.
11. Love C, Sun Z, JimaD, LiG, Zhang J, Miles R, et al. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet 2012;44:1321-5.
12. Licciulli S, Avila JL,Hanlon L, Troutman S,Cesaroni M, Kota S, et al. Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. Cancer Res 2013;73:5974-84.
13. Zage PE, Nolo R, FangW, Stewart J, Garcia-Manero G, Zweidler-McKay PA. Notch pathway activation induces neuroblastomatumor cell growth arrest. Pediatric Blood Cancer 2011;58:682-9.
14. Westhoff B, Colaluca IN, D'Ario G, Donzelli M, Tosoni D, Volorio S, et al. Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A 2009;106:22293-8.
15. Chen J, Imanaka N, Griffin JD. Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer 2009;102:351-60.
16. Meng RD, Shelton CC, Li YM,Qin LX, Notterman D, Paty PB, et al. gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res 2009;69:573-82.
17. Kannan S, Sutphin RM, Hall MG, Golfman LS, Fang W, Nolo RM, et al. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med 2013;210:321-37.
18. Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC, et al. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood 2005;106:3898-906.
19. Agrawal N, FrederickMJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011;333:1154-7.
20. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011;333:1157-60.
21. Song X, Xia R, Li J, Long Z, Ren H, Chen W, et al. Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma. Clin Cancer Res 2014;20:701-10.
22. Izumchenko EG, Kai S, Jones S, Brait M, Agrawal N, Koch W, et al. Notch1 mutations are drivers of oral tumorigenesis. Cancer Prev Res 2015;8: 277-86.
23. Mao L, Lee JS, Fan YH, Ro JY, Batsakis JG, Lippman S, et al. Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment. Nat Med 1996;2:682-5.
24. Rosin MP, Cheng X, Poh C, Lam WL, Huang Y, Lovas J, et al. Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res 2000;6:357-62.
25. Zhang L, Poh CF, Williams M, Laronde DM, Berean K, Gardner PJ, et al. Loss of heterozygosity (LOH) profiles-validated risk predictors for progression to oral cancer. Cancer Prev Res 2012;5:1081-9.
26. Sun W, Gaykalova DA, Ochs MF, Mambo E, Arnaoutakis D, Liu Y, et al. Activation of the NOTCH pathway in head and neck cancer. Cancer Res 2014;74:1091-104.
27. Balint K, Xiao M, Pinnix CC, Soma A, Veres I, Juhasz I, et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 2005;115:3166-76.
28. Zender S, Nickeleit I, Wuestefeld T, SÖrensen I, Dauch D, Bozko P, et al. A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell 2013;23:784-95.
29. Marignol L, Rivera-Figueroa K, Lynch T, Hollywood D. Hypoxia, notch signalling, and prostate cancer. Nat Rev Urol 2013;10:405-13.
30. Song X, Xia R, Cui Z, Chen W, Mao L. Presenilin 1 is frequently over-expressed and positively associates with epidermal growth factor receptor expression in head and neck squamous cell carcinoma. Head Neck Oncol 2012;4:47.