Epigenetic modulations in activated cells early after HIV-1 infection and their possible functional consequences

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Maricato, Juliana T ^a   Furtado, Maria N ^a   Takenaka, Maisa C ^a   Nunes, Edsel R M ^a   Fincatti, Patricia ^a   Meliso, Fabiana M ^a   Da Silva, Ismael D C G ^a   Jasiulionis, Miriam G ^a   De Araripe Sucupira, Maria Cecília ^a   Diaz, Ricardo Sobhie ^a   Janini, Luiz M R ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; HISTONE;

ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRMT8 GENE; QUANTITATIVE ASSAY; RPS6KA3 GENE; RSK2 GENE; SETD6 GENE; SETDB2 GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING; CELL CLONE; GENETIC EPIGENESIS; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; PROTEIN PROCESSING; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; EPIGENESIS, GENETIC; HISTONES; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84927582213     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119234     Document Type: Article

References (44)

1. Delcuve GP, Rastegar M, Davie JR. Epigenetic Control. Journal Cellular Phisiology. 2009; 219 (2):243-50. doi: 10.1002/jcp.21678 PMID: 19127539
2. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nature Reviews Genetics. 2007; 8(4):253-62. PMID: 17363974
3. Yedavalli VRK, Jeang KT. Methylation: a regulator of HIV-1-1 replication? Retrovirology. 2007: 4: 9. PMID: 17274823
4. Grant PA. A tale of histone modifications. Genome Biology. 2001; 2(4): 1-6.
5. Robertson KD. DNA methylation and human disease. Nature Reviews Genetics. 2005; 6: 597-610. PMID: 16136652
6. Su PF, Lee TC, Lin PJ, Lee PH, Jeng YM, Chen CH, et al. Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. Int. J. Cancer. 2007; 121: 1257-1264. PMID: 17534893
7. Niller HH, Wolf H, Minarovits J. Epigenetic dysregulation of the host cell genome in Epstein-Barr virusassociated neoplasia. Seminars in Cancer Biology. 2009; 19:158-164. doi: 10.1016/j.semcancer. 2009.02.012 PMID: 19429479
8. Willemsen NM, Hitchen EM, Bodetti TJ, Apolloni A, Warrilow D, Piller SC et al. Protein methylation is required to maintain optimal HIV-1-1 infectivity. Retrovirology. 2006; 3:92. PMID: 17169163
9. Ylisastigui L, Archin NM, Lehrman G, Bosch RJ, Margolis DM. Coaxing HIV-1-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression. AIDS. 2004; 18(8): 1101-8. PMID: 15166525
10. Ishida T, Hamano A, Koiwa T, Watanabe T. 5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1-1 provirus that is demethylated by reactivation signals. Retrovirology. 2006; 3: 69. PMID: 17034647
11. Wang GP, Ciuffi A, Leipzig J, Berry CC, Bushman FD. HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Res. 2007; 17:1-9. PMID: 17151344
12. Isräel N, Gougerot-Pocidalo MA. Oxidative stress in human immunodeficiency virus infection. CMLS. 1997; 53: 864-870 PMID: 9447238
13. Youngblood B, Noto A, Porichis F Akondy RS, Ndhlovu ZM, Austin JW et al. Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells. J Immunol.2013; 191(2):540-4. doi: 10.4049/jimmunol.1203161 PMID: 23772031
14. Abdel Hameed EA, Ji H, Sherman KE, Shata MT. Epigenetic modification of FOXP3 in patients with chronic HIV infection. J Acquir Immune Defic Syndr. 2014; 65(1):19-26. doi: 10.1097/QAI. 0b013e3182a1bca4 PMID: 23846566
15. Desplats P, Dumaop W, Smith D, Adame A, Everall I Letendre S et al. Molecular and pathologic insights from latent HIV-1 infection in the human brain. 2013;; 80(15):1415-23.
16. Wu YL, Wang D, Peng XE, Chen YL, Zheng DL, Chen WN et al. Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by Hepatitis B virus-X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells. Free Radic Biol Med. 2013; 65:632-44. doi: 10.1016/j. freeradbiomed.2013.07.037 PMID: 23920313
17. Woellmer A, Hammerschmidt W. Epstein-Barr virus and host cell methylation: regulation of latency, replication and virus reactivation. Current Opinion in Virology. 2013; 3:260-265. doi: 10.1016/j.coviro. 2013.03.005 PMID: 23567077
18. Liu XF, Wang X, Yan S, Zhang Z, Abecassis M, Hummel M. Epigenetic control of cytomegalovirus latency and reactivation.Viruses, 2013; 5(5):1325-45. doi: 10.3390/v5051325 PMID: 23698401
19. Van Lint C, Bouchat S, Marcello A. HIV-1 transcription and latency: an update.Retrovirology. 2013; 26;10:67.
20. Vatakis DN, Nixon CC, Bristol G, Zack JA. Differentially Stimulated CD4+ T Cells Display Altered Human Immunodeficiency Virus Infection Kinetics: Implications for the Efficacy of Antiviral Agents. J. Virol. 2009; 83(7): 3374-3378. doi: 10.1128/JVI.02161-08 PMID: 19129455
21. Parker MI, de Haan JB, Gevers W. DNA hypermethylation in sodium butyrate-treated WI-38 fibroblasts. J Biol Chem. 1986; 261(6): 2786-90. PMID: 2419322
22. Sharma S, De Carvalho DD, Jeong S, Jones PA, Liang G. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet. 2011; 7(2):e1001286. doi: 10.1371/journal.pgen.1001286 PMID: 21304883
23. Molognoni F, Cruz AT, Meliso FM, Morais AS, Souza CF, Xander P et al. Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics. 2011; 6(4):450-64. PMID: 21343701
24. Profiler PCR Array System Pathway-Focused Gene Expression Profiling Using Real-Time PCR Handbook. SA Bioscieneces. 2010; 5.
25. Arikawa E, Quellhorst E, Hongguang Y, Pan H, Yang J. RT2 Profiler PCR Arrays:Pathway-Focused Gene Expression Profiling with qRT-PCR. SA Bioscience, 2010.
26. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008; 3: 1101-1108. PMID: 18546601
27. O'Brien WA, Namazi A, Kalhor H, Mao SH, Zack JA, Chen IS. Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors J Virol. 1994; 68(2):1258-63. PMID: 7507180
28. Zack JA, Kim SG, Vatakis DN. HIV restriction in quiescent CD4? T cells. Retrovirol. 2013; 10: 37.
29. Kauder SE, Bosque A, Lindqvist A, Planelles V, Verdin E. Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathog. 2009; 5(6):490-495.
30. Iafrate AJ, Bronson S, Skowronski J. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling EMBO J. 1997; 16(4):673-84. PMID: 9049297
31. Westby M, Marriott JB, Guckian M, Cookson S, Hay S, Dalgleish AG. Abnormal intracellular IL-2 and in-terferon-gamma (IFN-γ) production as HIV-1-associated markers of immune dysfunction. Clin Exp Immunol. 1998; 111(2): 257-263. PMID: 9486390
32. Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, DeOliveira D et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014; 20(1):61-72. doi: 10.1016/j.cmet.2014.05.004 PMID: 24930970
33. Loisel-Meyer S, Swainson L, Craveiro M, Oburoglu L, Mongellaz C, Costa C et al. Glut1-mediated glucose transport regulates HIV infection. Proc Natl Acad Sci. 2012; 14; 109(7):2549-54. doi: 10.1073/ pnas.1121427109 PMID: 22308487
34. Bullen KC, Laird GM, Durand CM, Siliciano JD, Siliciano RF. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nature Medicine. 2014; 20, 425-429. doi: 10.1038/nm.3489 PMID: 24658076
35. Korin YD, Zack JA. Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells. J Virol. 1998; 72(4):3161-8. PMID: 9525642
36. Blazkova J, Trejbalova K, Gondois-Rey F, Halfon P, Philibert P, Guiquen A et al. CpG methylation controls reactivation of HIV from latency. PLoS Pathog. 2009; 5(8):1000554 doi: 10.1371/journal.ppat. 1000554 PMID: 19696893
37. Ho Ya-Chi, Shan L, Hosmane NN, Wang J, Laskey SB, Rosenbloom DI et al. Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure. Cell. 2013; 155 (3):540-51. doi: 10.1016/j.cell.2013.09.020 PMID: 24243014
38. Zhang X, Tamaru H, Khan SI, Horton JR, Keefer LJ, Selker EU et al. Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell. 2002; 111(1):117-27. PMID: 12372305
39. Guimiot F, Delezoide AL, Hanauer A, Simonneau M. Expression of the RSK2 gene during early human development. Gene Expr Patterns. 2004; 4(1):111-4. PMID: 14678837
40. Delaunoy J, Abidi F, Zeniou M, Jacquot S, Merienne K, Pannetier S et al. Mutations in the X-linked RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome. Hum Mutat. 2001; 17(2):103-16. PMID: 11180593
41. Delaunoy JP, Dubos A, Marques Pereira P, Hanauer A. Identification of novel mutations in the RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome. Clin Genet. 2006; 70(2):161-6. PMID: 16879200
42. Zeniou M, Gattoni R, Hanauer A, Stevenin J. Delineation of the mechanisms of aberrant splicing caused by two unusual intronic mutations in the RSK2 gene involved in Coffin-Lowry syndrome. Nucleic Acids Res. 2004; 18; 32(3):1214-23. PMID: 14973203
43. Jost S, Tomezsko PJ, Rands K, Toth I, Lichterfeld M, Gandhi RT, et al. CD4+ T-cell help enhances NK cell function following therapeutic HIV-1 vaccination. J Virol. 2014; 88(15):8349-54. doi: 10.1128/JVI. 00924-14 PMID: 24829350
44. Lévy Y, Thiébaut R, Montes M, Lacabaratz C, Sloan L. Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load. Eur J Immunol. 2014; 44(9):2802-10. doi: 10.1002/eji.201344433 PMID: 25042008