Combined exposure to bacteria and cigarette smoke resembles characteristic phenotypes of human COPD in a murine disease model

Experimental and Toxicologic Pathology

Volumn 67, Issue 3, 2015, Pages 261-269

  Herr, Christian ^a   Han, Gang ^a   Li, Dong ^a   Tschernig, Thomas ^a   Dinh, Quoc Thai ^a   Beißwenger, Christoph ^a   Bals, Robert ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Bacteria; Chronic obstructive pulmonary disease; Emphysema; IBALT; IL 17; Inflammation

Indexed keywords

CIGARETTE SMOKE; INTERLEUKIN 17; SMOKE;

AIRWAY REMODELING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; EXPOSURE; FEMALE; GOBLET CELL; HAEMOPHILUS INFLUENZAE; HISTOPATHOLOGY; INFLAMMATORY CELL; LUNG EMPHYSEMA; LUNG FUNCTION TEST; LYMPH FOLLICLE; MACROPHAGE; MEDIATOR; METAPLASIA; MOUSE; NONHUMAN; PHENOTYPE; PNEUMONIA; RESPIRATORY TRACT INFLAMMATION; STEREOLOGY; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; HAEMOPHILUS INFECTION; HUMAN; LUNG; MICROBIOLOGY; PATHOLOGY; SMOKE; TOBACCO;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; LUNG; MICE; MICE, INBRED C57BL; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKE; TOBACCO;

EID: 84927553422     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2015.01.002     Document Type: Article

References (38)

1. Barnes P.J. Chronic obstructive pulmonary disease. N Engl J Med 2000, 343:269-280.
2. Bartalesi B., Cavarra E., Fineschi S., Lucattelli M., Lunghi B., Martorana P.A., et al. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J 2005, 25:15-22.
3. Brass D.M., Savov J.D., Gavett S.H., Haykal-Coates N., Schwartz D.A. Subchronic endotoxin inhalation causes persistent airway disease. Am J Physiol Lung Cell Mol Physiol 2003, 285:L755-L761.
4. Churg A., Sin D.D., Wright J.L. Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use. Am J Respir Cell Mol Biol 2011, 45:1111-1115.
5. Churg A., Wang R.D., Xie C., Wright J.L. Alpha-1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2003, 168:199-207.
6. Churg A., Wang X., Wang R.D., Meixner S.C., Pryzdial E.L., Wright J.L. Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages. Am J Respir Cell Mol Biol 2007, 37:144-151.
7. Erb-Downward J.R., Thompson D.L., Han M.K., Freeman C.M., McCloskey L., Schmidt L.A., et al. Analysis of the lung microbiome in the healthy smoker and in COPD. PLoS ONE 2011, 6:e16384.
8. Fahy J.V., Dickey B.F. Airway mucus function and dysfunction. N Engl J Med 2010, 363:2233-2247.
9. Fehrenbach H. Animal models of chronic obstructive pulmonary disease: some critical remarks. Pathobiology 2002, 70:277-283.
10. Foster W.M., Langenback E.G., Bergofsky E.H. Disassociation in the mucociliary function of central and peripheral airways of asymptomatic smokers. Am Rev Respir Dis 1985, 132:633-639.
11. Ganesan S., Comstock A.T., Kinker B., Mancuso P., Beck J.M., Sajjan U.S. Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice. Respir Res 2014, 15:11.
12. Gaschler G.J., Skrtic M., Zavitz C.C., Lindahl M., Onnervik P.O., Murphy T.F., et al. Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile. Am J Respir Crit Care Med 2009, 179:666-675.
13. Gaschler G.J., Zavitz C.C., Bauer C.M., Stampfli M.R. Mechanisms of clearance of nontypeable Haemophilus influenzae from cigarette smoke-exposed mouse lungs. Eur Respir J 2010, 36:1131-1142.
14. Heijink I.H., Brandenburg S.M., Postma D.S., van Oosterhout A.J. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 2012, 39:419-428.
15. Herr C., Beisswenger C., Hess C., Kandler K., Suttorp N., Welte T., et al. Suppression of pulmonary innate host defence in smokers. Thorax 2009, 64:144-149.
16. Hill A.T., Campbell E.J., Bayley D.L., Hill S.L., Stockley R.A. Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ) 56. Am J Respir Crit Care Med 1999, 160:1968-1975.
17. Hodge S., Hodge G., Ahern J., Jersmann H., Holmes M., Reynolds P.N. Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2007, 37:748-755.
18. Hogg J.C., Chu F., Utokaparch S., Woods R., Elliott W.M., Buzatu L., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004, 350:2645-2653.
19. Hollingsworth J.W., Chen B.J., Brass D.M., Berman K., Gunn M.D., Cook D.N., et al. The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. Am J Respir Crit Care Med 2005, 171:806-813.
20. Huvenne W., Lanckacker E.A., Krysko O., Bracke K.R., Demoor T., Hellings P.W., et al. Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice. Respir Res 2011, 12:69.
21. Knust J., Ochs M., Gundersen H.J., Nyengaard J.R. Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs. Anat Rec 2009, 292:113-122.
22. Kranenburg A.R., Willems-Widyastuti A., Moori W.J., Sterk P.J., Alagappan V.K., de Boer W.I., et al. Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease. Am J Clin Pathol 2006, 126:725-735.
23. Moghaddam S.J., Clement C.G., De la Garza M.M., Zou X., Travis E.L., Young H.W., et al. Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype. Am J Respir Cell Mol Biol 2008, 38:629-638.
24. Murphy T.F., Brauer A.L., Schiffmacher A.T., Sethi S. Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004, 170:266-272.
25. Nikota J.K., Shen P., Morissette M.C., Fernandes K., Roos A., Chu D.K., et al. Cigarette smoke primes the pulmonary environment to IL-1alpha/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice. J Immunol 2014, 193:3134-3145.
26. Pemberton P.A., Kobayashi D., Wilk B.J., Henstrand J.M., Shapiro S.D., Barr P.J. Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. COPD 2006, 3:101-108.
27. Pfeifer P., Voss M., Wonnenberg B., Hellberg J., Seiler F., Lepper P.M., et al. IL-17C is a mediator of respiratory epithelial innate immune response. Am J Respir Cell Mol Biol 2013, 48:415-421.
28. Raman A.S., Swinburne A.J., Fedullo A.J. Pneumococcal adherence to the buccal epithelial cells of cigarette smokers. Chest 1983, 83:23-27.
29. Salazar L.M., Herrera A.M. Fibrotic response of tissue remodeling in COPD. Lung 2011, 189:101-109.
30. Sethi S. Infection as a comorbidity of COPD. Eur Respir J 2010, 35:1209-1215.
31. Sethi S., Evans N., Grant B.J., Murphy T.F. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 2002, 347:465-471.
32. Sethi S., Maloney J., Grove L., Wrona C., Berenson C.S. Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006, 173:991-998.
33. Sethi S., Murphy T.F. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 2008, 359:2355-2365.
34. Shapiro S.D. Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease. Eur Respir J 2007, 29:375-378.
35. Sze M.A., Dimitriu P.A., Hayashi S., Elliott W.M., McDonough J.E., Gosselink J.V., et al. The lung tissue microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012, 185:1073-1080.
36. Taraseviciene-Stewart L., Voelkel N.F. Molecular pathogenesis of emphysema. J Clin Invest 2008, 118:394-402.
37. Wilkinson T.M., Patel I.S., Wilks M., Donaldson G.C., Wedzicha J.A. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003, 167:1090-1095.
38. Zakharkina T., Heinzel E., Koczulla R.A., Greulich T., Rentz K., Pauling J.K., et al. Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing. PLoS ONE 2013, 8:e68302.