메뉴 건너뛰기




Volumn 102, Issue 1, 2015, Pages 17-23

Intratumoral heterogeneity and consequences for targeted therapies

Author keywords

Drug resistance; Gene mutation; MALDI imaging; Proteomics; Tumor relapse

Indexed keywords

PROTEIN; GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

EID: 84927544635     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1016/j.bulcan.2014.12.006     Document Type: Review
Times cited : (17)

References (52)
  • 1
    • 0001400561 scopus 로고
    • The chromosomes in ontogeny and oncogeny
    • Hauschka TS. The chromosomes in ontogeny and oncogeny. Cancer Res 1961;21:957-74.
    • (1961) Cancer Res , vol.21 , pp. 957-974
    • Hauschka, T.S.1
  • 2
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194(4260):23-8.
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 3
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz Jr, Williams RT, Wu J, et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 2012;486(7404):537-40.
    • (2012) Nature , vol.486 , Issue.7404 , pp. 537-540
    • Diaz1    Williams, R.T.2    Wu, J.3
  • 4
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin N, Kendall J, Troge J, et al. Tumour evolution inferred by single-cell sequencing. Nature 2011;478(7341):90-4.
    • (2011) Nature , vol.478 , Issue.7341 , pp. 90-94
    • Navin, N.1    Kendall, J.2    Troge, J.3
  • 5
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012;366(10):883-92.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 6
    • 83455176258 scopus 로고    scopus 로고
    • Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    • Snuderl M, Fazlollahi L, Le LP, et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 2011;20(6):810-7.
    • (2011) Cancer Cell , vol.20 , Issue.6 , pp. 810-817
    • Snuderl, M.1    Fazlollahi, L.2    Le, L.P.3
  • 7
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens PJ, Tarpey PS, Davies H, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 2012;486 (7403):400-4.
    • (2012) Nature , vol.486 , Issue.7403 , pp. 400-404
    • Stephens, P.J.1    Tarpey, P.S.2    Davies, H.3
  • 8
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature 2013;500(7463):415-21.
    • (2013) Nature , vol.500 , Issue.7463 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 9
    • 0037468517 scopus 로고    scopus 로고
    • Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    • Sieber OM, Lipton L, Crabtree M, et al. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med 2003;348(9):791-9.
    • (2003) N Engl J Med , vol.348 , Issue.9 , pp. 791-799
    • Sieber, O.M.1    Lipton, L.2    Crabtree, M.3
  • 10
    • 0037152628 scopus 로고    scopus 로고
    • Tobacco smoke carcinogens. DNA damage and p53 mutations in smoking-associated cancers
    • Pfeifer GP, Denissenko MF, Olivier M, et al. Tobacco smoke carcinogens. DNA damage and p53 mutations in smoking-associated cancers. Oncogene 2002;21(48):7435-51.
    • (2002) Oncogene , vol.21 , Issue.48 , pp. 7435-7451
    • Pfeifer, G.P.1    Denissenko, M.F.2    Olivier, M.3
  • 11
    • 0027379357 scopus 로고
    • Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients
    • Dumaz N, Drougard C, Sarasin A, et al. Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients. Proc Natl Acad Sci U S A 1993;90:10529-33.
    • (1993) Proc Natl Acad Sci u S a , vol.90 , pp. 10529-10533
    • Dumaz, N.1    Drougard, C.2    Sarasin, A.3
  • 12
    • 78650151378 scopus 로고    scopus 로고
    • Towards an inventory of oncogenic mutations in cancer
    • Theillet C. Towards an inventory of oncogenic mutations in cancer. Bull Cancer 2010;97 (11):1223-9.
    • (2010) Bull Cancer , vol.97 , Issue.11 , pp. 1223-1229
    • Theillet, C.1
  • 13
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • Govindan R, Ding L, Griffith M, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 2012;150:1121-34.
    • (2012) Cell , vol.150 , pp. 1121-1134
    • Govindan, R.1    Ding, L.2    Griffith, M.3
  • 14
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012;486(7403):395-9.
    • (2012) Nature , vol.486 , Issue.7403 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3
  • 15
    • 79957815376 scopus 로고    scopus 로고
    • Future medical applications of single-cell sequencing in cancer
    • Navin N, Hicks J. Future medical applications of single-cell sequencing in cancer. Genome Med 2011;3(5):31.
    • (2011) Genome Med , vol.3 , Issue.5 , pp. 31
    • Navin, N.1    Hicks, J.2
  • 16
    • 84884407337 scopus 로고    scopus 로고
    • Tumour heterogeneity in the clinic
    • Bedard PL, Hansen AR, Ratain MJ, et al. Tumour heterogeneity in the clinic. Nature 2013;501(7467):355-64.
    • (2013) Nature , vol.501 , Issue.7467 , pp. 355-364
    • Bedard, P.L.1    Hansen, A.R.2    Ratain, M.J.3
  • 17
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton C. Intratumor heterogeneity: evolution through space and time. Cancer Res 2012;72:4875-82.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 18
    • 84864045330 scopus 로고    scopus 로고
    • EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas
    • Chen ZY, Zhong WZ, Zhang XC, et al. EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas. Oncologist 2012; 17:978-85.
    • (2012) Oncologist , vol.17 , pp. 978-985
    • Chen, Z.Y.1    Zhong, W.Z.2    Zhang, X.C.3
  • 19
    • 84861550476 scopus 로고    scopus 로고
    • The life history of 21 breast cancers
    • Nik-Zainal S, Van Loo P, Wedge DC, et al. The life history of 21 breast cancers. Cell 2012; 149:994-1007.
    • (2012) Cell , vol.149 , pp. 994-1007
    • Nik-Zainal, S.1    Van Loo, P.2    Wedge, D.C.3
  • 20
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein CA. Parallel progression of primary tumours and metastases. Nat Rev Cancer 2009;9:302-12.
    • (2009) Nat Rev Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 21
    • 84856233963 scopus 로고    scopus 로고
    • Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast
    • Banys M, Gruber I, Krawczyk N, et al. Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast. Breast Cancer Res Treat 2012;131:801-8.
    • (2012) Breast Cancer Res Treat , vol.131 , pp. 801-808
    • Banys, M.1    Gruber, I.2    Krawczyk, N.3
  • 22
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Hüsemann Y, Geigl JB, Schubert F, et al. Systemic spread is an early step in breast cancer. Cancer Cell 2008;13:58-68.
    • (2008) Cancer Cell , vol.13 , pp. 58-68
    • Hüsemann, Y.1    Geigl, J.B.2    Schubert, F.3
  • 23
    • 80052970594 scopus 로고    scopus 로고
    • Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ
    • Sänger N, Effenberger KE, Riethdorf S, et al. Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ. Int J Cancer 2011;129:2522-6.
    • (2011) Int J Cancer , vol.129 , pp. 2522-2526
    • Sänger, N.1    Effenberger, K.E.2    Riethdorf, S.3
  • 24
    • 0037206022 scopus 로고    scopus 로고
    • Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
    • Klein CA, Blankeinstein TJ, Schmidt-Kittler O, et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002;360:683-9.
    • (2002) Lancet , vol.360 , pp. 683-689
    • Klein, C.A.1    Blankeinstein, T.J.2    Schmidt-Kittler, O.3
  • 25
    • 24944534497 scopus 로고    scopus 로고
    • Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer
    • Schardt JA, Meyer M, Hartmann CH, et al. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell 2005;8:227-39.
    • (2005) Cancer Cell , vol.8 , pp. 227-239
    • Schardt, J.A.1    Meyer, M.2    Hartmann, C.H.3
  • 26
    • 0038271868 scopus 로고    scopus 로고
    • From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
    • Schmidt-Kittler O, Ragg T, Daskalakis A, et al. From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A 2003;100:7737-42.
    • (2003) Proc Natl Acad Sci u S a , vol.100 , pp. 7737-7742
    • Schmidt-Kittler, O.1    Ragg, T.2    Daskalakis, A.3
  • 27
    • 84878901123 scopus 로고    scopus 로고
    • Circulating tumor cells and advanced prostate cancer
    • Murez T, Droupy S, Rebillard X, et al. Circulating tumor cells and advanced prostate cancer. Bull Cancer 2012;99:S4-15.
    • (2012) Bull Cancer , vol.99 , pp. S4-S15
    • Murez, T.1    Droupy, S.2    Rebillard, X.3
  • 28
    • 63749083366 scopus 로고    scopus 로고
    • Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer
    • Weckermann D, Polzer B, Ragg T, et al. Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer. J Clin Oncol 2009;27: 1549-56.
    • (2009) J Clin Oncol , vol.27 , pp. 1549-1556
    • Weckermann, D.1    Polzer, B.2    Ragg, T.3
  • 29
    • 84864085607 scopus 로고    scopus 로고
    • Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression
    • Lindström LS, Karisson E, Wilking UM, et al. Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression. J Clin Oncol 2012;30:2601-8.
    • (2012) J Clin Oncol , vol.30 , pp. 2601-2608
    • Lindström, L.S.1    Karisson, E.2    Wilking, U.M.3
  • 30
    • 70849093383 scopus 로고    scopus 로고
    • Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer
    • Liedtke C, Broglio K, Moulder S, et al. Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer. Ann Oncol 2009;20:1953-8.
    • (2009) Ann Oncol , vol.20 , pp. 1953-1958
    • Liedtke, C.1    Broglio, K.2    Moulder, S.3
  • 31
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012;21: 309-22.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 32
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: Complex tissues that interface with the entire organism
    • Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 2010;18:884-901.
    • (2010) Dev Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 33
    • 84864286442 scopus 로고    scopus 로고
    • Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
    • Wilson TR, Fridlyand J, Yan Y, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012;487:505-9.
    • (2012) Nature , vol.487 , pp. 505-509
    • Wilson, T.R.1    Fridlyand, J.2    Yan, Y.3
  • 34
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    • Straussman R, Morikawa T, Shee K, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012;487:500-4.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3
  • 35
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009;15:21-34.
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3
  • 36
    • 77958501473 scopus 로고    scopus 로고
    • DNA damagemediated induction of a chemoresistant niche
    • Gilbert LA, Hemann MT. DNA damagemediated induction of a chemoresistant niche. Cell 2010;143:355-66.
    • (2010) Cell , vol.143 , pp. 355-366
    • Gilbert, L.A.1    Hemann, M.T.2
  • 37
    • 84867685827 scopus 로고    scopus 로고
    • Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
    • Landsberg J, Kohlmeyer J, Renn M, et al. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature 2012;490:412-6.
    • (2012) Nature , vol.490 , pp. 412-416
    • Landsberg, J.1    Kohlmeyer, J.2    Renn, M.3
  • 38
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila MR, de Sauvage FJ. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013;501(7467): 346-54.
    • (2013) Nature , vol.501 , Issue.7467 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 39
    • 34548069945 scopus 로고    scopus 로고
    • Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
    • Hafner C, Lopez-Knowles E, Luis NM, et al. Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A 2007;104:13450-54.
    • (2007) Proc Natl Acad Sci u S a , vol.104 , pp. 13450-13454
    • Hafner, C.1    Lopez-Knowles, E.2    Luis, N.M.3
  • 40
    • 78650582977 scopus 로고    scopus 로고
    • Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors
    • Hafner C, Toll A, Fernandez-Casado A, et al. Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A 2010;107:20780-85.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20780-20785
    • Hafner, C.1    Toll, A.2    Fernandez-Casado, A.3
  • 41
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos PD, Zhang XH, Nadal C, et al. Genes that mediate breast cancer metastasis to the brain. Nature 2009;459:1005-9.
    • (2009) Nature , vol.459 , pp. 1005-1009
    • Bos, P.D.1    Zhang, X.H.2    Nadal, C.3
  • 42
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49.
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 43
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436:518-24.
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3
  • 44
    • 84875934361 scopus 로고    scopus 로고
    • Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors
    • Jones EA, Schmitz N, Waaijer CJ, et al. Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors. J Proteome Res 2013;12(4):1847-55.
    • (2013) J Proteome Res , vol.12 , Issue.4 , pp. 1847-1855
    • Jones, E.A.1    Schmitz, N.2    Waaijer, C.J.3
  • 45
    • 84916200561 scopus 로고    scopus 로고
    • De novo discovery of phenotypic intra-tumor heterogeneity using imaging mass spectrometry
    • Balluff B, Frese CK, Maier SK, et al. De novo discovery of phenotypic intra-tumor heterogeneity using imaging mass spectrometry. J Pathol 2015;235(5):3-13.
    • (2015) J Pathol , vol.235 , Issue.5 , pp. 3-13
    • Balluff, B.1    Frese, C.K.2    Maier, S.K.3
  • 46
    • 84897431598 scopus 로고    scopus 로고
    • Tumoral heterogeneity of hepatic cholangiocarcinomas revealed by MALDI imaging mass spectrometry
    • Le Faouder J, Laouirem S, Alexandrov T, et al. Tumoral heterogeneity of hepatic cholangiocarcinomas revealed by MALDI imaging mass spectrometry. Proteomics 2014;14(7-8):965-72.
    • (2014) Proteomics , vol.14 , Issue.7-8 , pp. 965-972
    • Le Faouder, J.1    Laouirem, S.2    Alexandrov, T.3
  • 47
    • 84871778930 scopus 로고    scopus 로고
    • Laser microdissection and two-dimensional difference gel electrophoresis reveal proteomic intra-tumor heterogeneity in colorectal cancer
    • Sugihara Y, Taniguchi H, Kushima R, et al. Laser microdissection and two-dimensional difference gel electrophoresis reveal proteomic intra-tumor heterogeneity in colorectal cancer. J Proteomics 2013;78:134-47.
    • (2013) J Proteomics , vol.78 , pp. 134-147
    • Sugihara, Y.1    Taniguchi, H.2    Kushima, R.3
  • 48
    • 84896706261 scopus 로고    scopus 로고
    • Organized proteomic heterogeneity in colorectal cancer liver metastases and implications for therapies
    • Turtoi A, Blomme A, Debois D, et al. Organized proteomic heterogeneity in colorectal cancer liver metastases and implications for therapies. Hepatology 2014;59(3):924-34.
    • (2014) Hepatology , vol.59 , Issue.3 , pp. 924-934
    • Turtoi, A.1    Blomme, A.2    Debois, D.3
  • 49
    • 79251490378 scopus 로고    scopus 로고
    • Innovative proteomics for the discovery of systemically accessible cancer biomarkers suitable for imaging and targeted therapies
    • Turtoi A, De Pauw E, Castronovo V. Innovative proteomics for the discovery of systemically accessible cancer biomarkers suitable for imaging and targeted therapies. Am J Pathol 2011;178(1):12-8.
    • (2011) Am J Pathol , vol.178 , Issue.1 , pp. 12-18
    • Turtoi, A.1    De Pauw, E.2    Castronovo, V.3
  • 50
    • 84872866038 scopus 로고    scopus 로고
    • Small targeted cytotoxics: Current state and promises from DNA-encoded chemical libraries
    • Krall N, Scheuermann J, Neri D. Small targeted cytotoxics: current state and promises from DNA-encoded chemical libraries. Angew Chem Int Ed Engl 2013;52(5):1384-402.
    • (2013) Angew Chem Int Ed Engl , vol.52 , Issue.5 , pp. 1384-1402
    • Krall, N.1    Scheuermann, J.2    Neri, D.3
  • 51
    • 84908551380 scopus 로고    scopus 로고
    • The development of immunoconjugates for targeted cancer therapy
    • Smaglo BG, Aldeghaither D, Weiner LM. The development of immunoconjugates for targeted cancer therapy. Nat Rev Clin Oncol 2014;11(11):637-48.
    • (2014) Nat Rev Clin Oncol , vol.11 , Issue.11 , pp. 637-648
    • Smaglo, B.G.1    Aldeghaither, D.2    Weiner, L.M.3
  • 52
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012;367 (19):1783-91.
    • (2012) N Engl J Med , vol.367 , Issue.19 , pp. 1783-1791
    • Verma, S.1    Miles, D.2    Gianni, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.