메뉴 건너뛰기




Volumn 60, Issue 1, 2014, Pages 84-92

Cortisol: The villain in metabolic syndrome?

Author keywords

11 Hydroxysteroid; Dehydrogenase; Glucocorticoids; Insulin resistance; Metabolic syndrome; Obesity; Stress

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ADIPOCYTOKINE; ADIPONECTIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTISONE; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; HYDROCORTISONE; INSULIN; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; VASOPRESSIN;

EID: 84927173219     PISSN: 01044230     EISSN: None     Source Type: Journal    
DOI: 10.1590/1806-9282.60.01.017     Document Type: Article
Times cited : (46)

References (53)
  • 1
    • 70449729523 scopus 로고    scopus 로고
    • Stress hormones: Physiological stress and regulation of metabolism
    • Kyrou I, Tsigos C. Stress hormones: physiological stress and regulation of metabolism. Curr Opin Pharmacol. 2009;9:787-93.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 787-793
    • Kyrou, I.1    Tsigos, C.2
  • 2
    • 33845667299 scopus 로고    scopus 로고
    • The hypothalamic-pituitaryadrenal axis activity in obesity and the metabolic syndrome
    • Pasquali R, Vicennati V, Cacciari M, Pagotto U. The hypothalamic-pituitaryadrenal axis activity in obesity and the metabolic syndrome. Ann N Y Acad Sci. 2006;1083:111-28.
    • (2006) Ann N Y Acad Sci , vol.1083 , pp. 111-128
    • Pasquali, R.1    Vicennati, V.2    Cacciari, M.3    Pagotto, U.4
  • 3
    • 33845611051 scopus 로고    scopus 로고
    • Stress, visceral obesity, and metabolic complications
    • Kyrou I, Chrousos G, Tsigos C. Stress, visceral obesity, and metabolic complications. Ann N Y Acad Sci. 2006;1083:77-110.
    • (2006) Ann N Y Acad Sci , vol.1083 , pp. 77-110
    • Kyrou, I.1    Chrousos, G.2    Tsigos, C.3
  • 4
    • 0032078238 scopus 로고    scopus 로고
    • Stress, adaptation, and disease. Allostasis and allostatic load
    • McWwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33-44.
    • (1998) Ann N Y Acad Sci , vol.840 , pp. 33-44
    • McWwen, B.S.1
  • 5
    • 39849090597 scopus 로고    scopus 로고
    • Is the metabolic syndrome an intracellular cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoidactivating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene
    • Iwasaki Y, Takayasu S, Nishiyama M, Tsugita M, Taguchi T, Asai M, et al. Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoidactivating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene. Mol Cell Endocrinol. 2008;285:10-8.
    • (2008) Mol Cell Endocrinol , vol.285 , pp. 10-18
    • Iwasaki, Y.1    Takayasu, S.2    Nishiyama, M.3    Tsugita, M.4    Taguchi, T.5    Asai, M.6
  • 6
    • 17144385790 scopus 로고    scopus 로고
    • Excess deaths associated with underweight, overweight, and obesity
    • Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005;293:1861-7.
    • (2005) JAMA , vol.293 , pp. 1861-1867
    • Flegal, K.M.1    Graubard, B.I.2    Williamson, D.F.3    Gail, M.H.4
  • 7
    • 84868285277 scopus 로고    scopus 로고
    • Diabetes treatment in 2025: Can scientific advances keep pace with prevalence?
    • Shomali M. Diabetes treatment in 2025: can scientific advances keep pace with prevalence? Ther Adv Endocrinol Metab. 2012;3:163-73.
    • (2012) Ther Adv Endocrinol Metab , vol.3 , pp. 163-173
    • Shomali, M.1
  • 8
    • 0037137285 scopus 로고    scopus 로고
    • Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: Nested case-control study
    • Brunner EJ, Hemingway H, Walker BR, Page M, Clarke P, Juneja M, et al. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation. 2002;106:2659-65.
    • (2002) Circulation , vol.106 , pp. 2659-2665
    • Brunner, E.J.1    Hemingway, H.2    Walker, B.R.3    Page, M.4    Clarke, P.5    Juneja, M.6
  • 10
    • 33644904316 scopus 로고    scopus 로고
    • Chronic stress at work and the metabolic syndrome: Prospective study
    • Chandola T, Brunner E, Marmot M. Chronic stress at work and the metabolic syndrome: prospective study. BMJ. 2006;332:521-5.
    • (2006) BMJ , vol.332 , pp. 521-525
    • Chandola, T.1    Brunner, E.2    Marmot, M.3
  • 11
    • 0031732443 scopus 로고    scopus 로고
    • Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities
    • Rosmond R, Dallman MF, Björntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab. 1998;83:1853-9.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1853-1859
    • Rosmond, R.1    Dallman, M.F.2    Björntorp, P.3
  • 13
    • 34547885436 scopus 로고    scopus 로고
    • Glucocorticoids, metabolism and metabolic diseases
    • Vegiopoulos A, Herzig S. Glucocorticoids, metabolism and metabolic diseases. Mol Cell Endocrinol. 2007;275:43-61.
    • (2007) Mol Cell Endocrinol , vol.275 , pp. 43-61
    • Vegiopoulos, A.1    Herzig, S.2
  • 14
    • 15444366462 scopus 로고    scopus 로고
    • The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome
    • Wang M. The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome. Nutr Metab (Lond). 2005;2:3.
    • (2005) Nutr Metab (Lond) , vol.2 , pp. 3
    • Wang, M.1
  • 15
    • 0036805791 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    • Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res. 2002;53:865-71.
    • (2002) J Psychosom Res , vol.53 , pp. 865-871
    • Tsigos, C.1    Chrousos, G.P.2
  • 16
    • 34447503556 scopus 로고    scopus 로고
    • Corticosteroid-binding globulin gene polymorphisms: Clinical implications and links to idiopathic chronic fatigue disorders
    • Torpy DJ, Ho JT. Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 2007;67:161-7.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 161-167
    • Torpy, D.J.1    Ho, J.T.2
  • 18
    • 34447105433 scopus 로고    scopus 로고
    • Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
    • Wamil M, Seckl JR. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target. Drug Discov Today. 2007;12:504-20.
    • (2007) Drug Discov Today , vol.12 , pp. 504-520
    • Wamil, M.1    Seckl, J.R.2
  • 19
    • 33845644003 scopus 로고    scopus 로고
    • Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease
    • Walker BR, Andrew R. Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease. Ann N Y Acad Sci. 2006;1083:165-84.
    • (2006) Ann N Y Acad Sci , vol.1083 , pp. 165-184
    • Walker, B.R.1    Andrew, R.2
  • 20
    • 34248148124 scopus 로고    scopus 로고
    • Extra-adrenal regeneration of glucocorticoids by 11betahydroxysteroid dehydrogenase type 1: Physiological regulator and pharmacological target for energy partitioning
    • Walker BR. Extra-adrenal regeneration of glucocorticoids by 11betahydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning. Proc Nutr Soc. 2007;66:1-8.
    • (2007) Proc Nutr Soc , vol.66 , pp. 1-8
    • Walker, B.R.1
  • 21
    • 4444269459 scopus 로고    scopus 로고
    • Role of stress in the pathogenesis of the metabolic syndrome
    • Rosmond R. Role of stress in the pathogenesis of the metabolic syndrome. Psychoneuroendocrinology. 2005;30:1-10.
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 1-10
    • Rosmond, R.1
  • 22
    • 70449413778 scopus 로고    scopus 로고
    • Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy
    • Brown ES. Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Ann N Y Acad Sci. 2009;1179:41-55.
    • (2009) Ann N Y Acad Sci , vol.1179 , pp. 41-55
    • Brown, E.S.1
  • 23
    • 60549103547 scopus 로고    scopus 로고
    • Síndrome metabólica em Portugal: Prevalência e implicações no risco cardiovascular: Resultados do Estudo Valsim
    • Fiuza M, Cortez-Dias N, Martins S, Belo A. Síndrome metabólica em Portugal: Prevalência e implicações no risco cardiovascular: resultados do Estudo Valsim. Rev Port Cardiol. 2008;27:1495-529.
    • (2008) Rev Port Cardiol , vol.27 , pp. 1495-1529
    • Fiuza, M.1    Cortez-Dias, N.2    Martins, S.3    Belo, A.4
  • 24
    • 69349100510 scopus 로고    scopus 로고
    • Social stress, visceral obesity, and coronary artery atherosclerosis: Product of a primate adaptation
    • Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009;71:742-51.
    • (2009) Am J Primatol , vol.71 , pp. 742-751
    • Shively, C.A.1    Register, T.C.2    Clarkson, T.B.3
  • 26
    • 77649148756 scopus 로고    scopus 로고
    • Razão cintura/estatura comparado a outros indicadores antropométricos de obesidade como preditor de risco coronariano elevado
    • Haun D, Pitanga F, Lessa I. Razão cintura/estatura comparado a outros indicadores antropométricos de obesidade como preditor de risco coronariano elevado. Rev Assoc Med Bras. 2009;55:705-11.
    • (2009) Rev Assoc Med Bras , vol.55 , pp. 705-711
    • Haun, D.1    Pitanga, F.2    Lessa, I.3
  • 27
    • 13544253065 scopus 로고    scopus 로고
    • Metabolic syndrome: A clinical and molecular perspective
    • Moller DE, Kaufman KD. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med. 2005;56:45-62.
    • (2005) Annu Rev Med , vol.56 , pp. 45-62
    • Moller, D.E.1    Kaufman, K.D.2
  • 28
    • 0030889677 scopus 로고    scopus 로고
    • Behavior and physiology of social stress and depression in female cynomolgus monkeys
    • Shively CA, Laber-Laird K, Anton RF. Behavior and physiology of social stress and depression in female cynomolgus monkeys. Biol Psychiatry. 1997;41:871-82.
    • (1997) Biol Psychiatry , vol.41 , pp. 871-882
    • Shively, C.A.1    Laber-Laird, K.2    Anton, R.F.3
  • 29
    • 84865975344 scopus 로고    scopus 로고
    • 11β-Hydroxysteroid dehydrogenase type 1: Relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus
    • Pereira CD, Azevedo I, Monteiro R, Martins MJ. 11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus. Diabetes Obes Metab. 2012;14:869-81.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 869-881
    • Pereira, C.D.1    Azevedo, I.2    Monteiro, R.3    Martins, M.J.4
  • 30
    • 0036324073 scopus 로고    scopus 로고
    • Tissue-specific changes in peripheral cortisol metabolism in obese women: Increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity
    • Rask E, Walker B, Söderberg S, Livingstone DE, Eliasson M, Johnson O, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab. 2002;87:3330-6.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3330-3336
    • Rask, E.1    Walker, B.2    Söderberg, S.3    Livingstone, D.E.4    Eliasson, M.5    Johnson, O.6
  • 31
    • 0032990860 scopus 로고    scopus 로고
    • Cortisol metabolism in human obesity: Impaired cortisone->cortisol conversion in subjects with central adiposity
    • Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH. Cortisol metabolism in human obesity: impaired cortisone->cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab. 1999;84:1022-7.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1022-1027
    • Stewart, P.M.1    Boulton, A.2    Kumar, S.3    Clark, P.M.4    Shackleton, C.H.5
  • 33
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev. 2000;21:697-738.
    • (2000) Endocr Rev , vol.21 , pp. 697-738
    • Wajchenberg, B.L.1
  • 34
    • 80054986457 scopus 로고    scopus 로고
    • The effects of glucocorticoids on adipose tissue lipid metabolism
    • Peckett AJ, Wright DC, Riddell MC. The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism. 2011;60:1500-10.
    • (2011) Metabolism , vol.60 , pp. 1500-1510
    • Peckett, A.J.1    Wright, D.C.2    Riddell, M.C.3
  • 35
    • 38649088252 scopus 로고    scopus 로고
    • Adipose tissue expression of 11betahydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity
    • Espíndola-Antunes D, Kater CE. Adipose tissue expression of 11betahydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity. Arq Bras Endocrinol Metab. 2007;51:1397-403.
    • (2007) Arq Bras Endocrinol Metab , vol.51 , pp. 1397-1403
    • Espíndola-Antunes, D.1    Kater, C.E.2
  • 36
    • 44949151646 scopus 로고    scopus 로고
    • AMPactivated protein kinase mediates glucocorticoid induced metabolic changes: A novel mechanism in Cushing's syndrome
    • Christ-Crain M, Kola B, Lolli F, Fekete C, Seboek D, Wittmann G, et al. AMPactivated protein kinase mediates glucocorticoid induced metabolic changes: a novel mechanism in Cushing's syndrome. FASEB. J 2008;22:1672-83.
    • (2008) FASEB J , vol.22 , pp. 1672-1683
    • Christ-Crain, M.1    Kola, B.2    Lolli, F.3    Fekete, C.4    Seboek, D.5    Wittmann, G.6
  • 37
    • 33751215200 scopus 로고    scopus 로고
    • Cortisol - Cause or cure for metabolic syndrome?
    • Walker BR. Cortisol - cause or cure for metabolic syndrome? Diabet Med. 2006;23:1281-8.
    • (2006) Diabet Med , vol.23 , pp. 1281-1288
    • Walker, B.R.1
  • 38
    • 84873742735 scopus 로고    scopus 로고
    • 11β-Hydroxysteroid dehydrogenase type 1: Potential therapeutic target for metabolic syndrome
    • Joharapurkar A, Dhanesha N, Shah G, Kharul R, Jain M. 11β-Hydroxysteroid dehydrogenase type 1: potential therapeutic target for metabolic syndrome. Pharmacol Rep. 2012;64:1055-65.
    • (2012) Pharmacol Rep , vol.64 , pp. 1055-1065
    • Joharapurkar, A.1    Dhanesha, N.2    Shah, G.3    Kharul, R.4    Jain, M.5
  • 39
    • 33750222847 scopus 로고    scopus 로고
    • Tecido adiposo e citocinas
    • Costa J, Duarte J. Tecido adiposo e citocinas. Acta Med Port. 2006;19:251-6.
    • (2006) Acta Med Port , vol.19 , pp. 251-256
    • Costa, J.1    Duarte, J.2
  • 40
    • 0031059756 scopus 로고    scopus 로고
    • Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle
    • Dimitriadis G, Leighton B, Parry-Billings M, Sasson S, Young M, Krause U, et al. Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochem J. 1997;321:707-12.
    • (1997) Biochem J , vol.321 , pp. 707-712
    • Dimitriadis, G.1    Leighton, B.2    Parry-Billings, M.3    Sasson, S.4    Young, M.5    Krause, U.6
  • 41
    • 77953631526 scopus 로고    scopus 로고
    • Adipose tissue, inflammation and cardiovascular disease
    • Ikeoka D, Madjer J, Pieber T. Adipose tissue, inflammation and cardiovascular disease. Rev Assoc Med Bras. 2010;56:116-21.
    • (2010) Rev Assoc Med Bras , vol.56 , pp. 116-121
    • Ikeoka, D.1    Madjer, J.2    Pieber, T.3
  • 42
    • 33751209234 scopus 로고    scopus 로고
    • Adiponectin, type 2 diabetes and the metabolic syndrome: Lessons from human genetic studies
    • Vasseur F, Meyre D, Froguel P. Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Rev Mol Med. 2006;20:1-12.
    • (2006) Expert Rev Mol Med , vol.20 , pp. 1-12
    • Vasseur, F.1    Meyre, D.2    Froguel, P.3
  • 43
    • 20644450344 scopus 로고    scopus 로고
    • Gordura visceral, subcutânea ou intramuscular: Onde está o problema?
    • Hermsdorff HH, Monteiro JB. Gordura visceral, subcutânea ou intramuscular: onde está o problema? Arq Bras Endocrinol Metab. 2004;48:803-11.
    • (2004) Arq Bras Endocrinol Metab , vol.48 , pp. 803-811
    • Hermsdorff, H.H.1    Monteiro, J.B.2
  • 44
    • 42949100803 scopus 로고    scopus 로고
    • The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
    • Nieuwenhuizen AG, Rutters F. The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiol Behav. 2008;94:169-77.
    • (2008) Physiol Behav , vol.94 , pp. 169-177
    • Nieuwenhuizen, A.G.1    Rutters, F.2
  • 45
    • 59649109958 scopus 로고    scopus 로고
    • Shaping the stress response: Interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity
    • Warne JP. Shaping the stress response: Interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity. Mol Cell Endocrinol. 2009;300:137-46.
    • (2009) Mol Cell Endocrinol , vol.300 , pp. 137-146
    • Warne, J.P.1
  • 46
    • 34347336424 scopus 로고    scopus 로고
    • Stress, eating and the reward system
    • Adam TC, Epel ES. Stress, eating and the reward system. Physiol Behav. 2007;91:449-58.
    • (2007) Physiol Behav , vol.91 , pp. 449-458
    • Adam, T.C.1    Epel, E.S.2
  • 47
  • 48
    • 67649406270 scopus 로고    scopus 로고
    • Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis
    • Wajchenberg BL, Nery M, Cunha MR, Silva ME. Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis. Arq Bras Endocrinol Metab. 2009;53:145-50.
    • (2009) Arq Bras Endocrinol Metab , vol.53 , pp. 145-150
    • Wajchenberg, B.L.1    Nery, M.2    Cunha, M.R.3    Silva, M.E.4
  • 49
    • 79959423583 scopus 로고    scopus 로고
    • Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: Study on the effect of Vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats
    • Sakamuri VP, Ananthathmakula P, Veettil GN, Ayyalasomayajula V. Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats. Nutr J. 2011;10:70.
    • (2011) Nutr J , vol.10 , pp. 70
    • Sakamuri, V.P.1    Ananthathmakula, P.2    Veettil, G.N.3    Ayyalasomayajula, V.4
  • 50
    • 84860229802 scopus 로고    scopus 로고
    • Modest reversal of metabolic syndrome manifestations with Vitamin D status correction: A 12-month prospective study
    • Al-Daghri N, Alkharfy K, Al-Saleh Y, Al-Attas O, Alokail M, Al-Othman A, et al. Modest reversal of metabolic syndrome manifestations with vitamin D status correction: a 12-month prospective study. Metabolism. 2012;61:661-6.
    • (2012) Metabolism , vol.61 , pp. 661-666
    • Al-Daghri, N.1    Alkharfy, K.2    Al-Saleh, Y.3    Al-Attas, O.4    Alokail, M.5    Al-Othman, A.6
  • 51
    • 33644826159 scopus 로고    scopus 로고
    • Dietary calcium, Vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. Women
    • Liu S, Song Y, Ford ES, Manson JE, Buring JE, Ridker PM. Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 2005;28:2926-32.
    • (2005) Diabetes Care , vol.28 , pp. 2926-2932
    • Liu, S.1    Song, Y.2    Ford, E.S.3    Manson, J.E.4    Buring, J.E.5    Ridker, P.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.