Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi

Translational Psychiatry

Volumn 5, Issue , 2015, Pages e545-

  Nemoda, Z ^a,g   Massart, R ^a   Suderman, M ^a,b   Hallett, M ^b   Li, T ^c   Coote, M ^c   Cody, N ^a   Sun, Z S ^d   Soares, C N ^c,e   Turecki, G ^f   Steiner, M ^c,e   Szyf, M ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d INSTITUTE OF PSYCHOLOGY   (China)

^e MCMASTER UNIVERSITY   (Canada)

^f MCGILL UNIVERSITY   (Canada)

^g SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CD3+ T LYMPHOCYTE; CELL ISOLATION; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA HYBRIDIZATION; DNA METHYLATION; EDINBURGH POSTNATAL DEPRESSION SCALE; ETHNICITY; FEMALE; GESTATIONAL AGE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LEUKOCYTE MIGRATION; MALE; MATERNAL SMOKING; MONTGOMERY ASBERG DEPRESSION RATING SCALE; PREGNANT WOMAN; PUERPERAL DEPRESSION; PYROSEQUENCING; TOBACCO USE; UMBILICAL CORD BLOOD; DEPRESSION; FETUS BLOOD; GENETIC EPIGENESIS; IMMUNOLOGY; MOTHER; PREGNANCY; PSYCHOLOGY; T LYMPHOCYTE;

ADULT; DEPRESSIVE DISORDER; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FETAL BLOOD; HIPPOCAMPUS; HUMANS; MOTHERS; PREGNANCY; T-LYMPHOCYTES;

EID: 84927164326     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2015.32     Document Type: Article

References (50)

1. Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annu Rev Public Health 2013; 34: 119-138.
2. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 2013; 382: 1575-1586.
3. Van de Velde S, Bracke P, Levecque K. Gender differences in depression in 23 European countries. Cross-national variation in the gender gap in depression. Soc Sci Med 2010; 71: 305-313.
4. Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol 2005; 106(5 Pt 1): 1071-1083.
5. Stewart DE. Clinical practice. Depression during pregnancy. N Engl J Med 2011; 365: 1605-1611.
6. Weinstock M. The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev 2008; 32: 1073-1086.
7. Brand SR, Brennan PA. Impact of antenatal and postpartum maternal mental illness: how are the children? Clin Obstet Gynecol 2009; 52: 441-455.
8. Kinsella MT, Monk C. Impact of maternal stress, depression and anxiety on fetal neurobehavioral development. Clin Obstet Gynecol 2009; 52: 425-440.
9. Szyf M. DNA methylation, behavior and early life adversity. J Genet Genomics 2013; 40: 331-338.
10. Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev 2011; 32: 159-224.
11. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 342-348.
12. Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One 2012; 7: e30148.
13. Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008; 3: 97-106.
14. Hompes T, Izzi B, Gellens E, Morreels M, Fieuws S, Pexsters A et al. Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood. J Psychiatr Res 2013; 47: 880-891.
15. Radtke KM, Ruf M, Gunter HM, Dohrmann K, Schauer M, Meyer A et al. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 2011; 1: e21.
16. Devlin AM, Brain U, Austin J, Oberlander TF. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 2010; 5: e12201.
17. Liu Y, Murphy SK, Murtha AP, Fuemmeler BF, Schildkraut J, Huang Z et al. Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics 2012; 7: 735-746.
18. Eyre H, Baune BT. Neuroplastic changes in depression: a role for the immune system. Psychoneuroendocrinology 2012; 37: 1397-1416.
19. Zunszain PA, Hepgul N, Pariante CM. Inflammation and depression. Curr Top Behav Neurosci 2013; 14: 135-151.
20. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59(Suppl 20): 22-33, quiz 34-57.
21. Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 150: 782-786.
22. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382-389.
23. Matthey S, Henshaw C, Elliott S, Barnett B. Variability in use of cut-off scores and formats on the Edinburgh Postnatal Depression Scale: implications for clinical and research practice. Arch Womens Ment Health 2006; 9: 309-315.
24. Hawley CJ, Gale TM, Sivakumaran T. Defining remission by cut off score on the MADRS: selecting the optimal value. J Affect Disord 2002; 72: 177-184.
25. Fuss IJ, Kanof ME, Smith PD, Zola H. Isolation of whole mononuclear cells from peripheral blood and cord blood. Curr Protoc Immunol 2009; Chapter 7: Unit 7.1.
26. Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 2014; 30: 1363-1369.
27. Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 2012; 13: 86.
28. Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-2074.
29. Teschendorff AE, Zhuang J, Widschwendter M. Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies. Bioinformatics 2011; 27: 1496-1505.
30. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B 1995; 57: 289-300.
31. Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 2013; 8: 203-209.
32. Johnson NL, Kotz S, Kemp A. W. Univariate Discrete Distributions, 2nd edition, Wiley: New York, NY, USA, 1992.
33. Labonte B, Suderman M, Maussion G, Navaro L, Yerko V, Mahar I et al. Genomewide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 2012; 69: 722-731.
34. Maxwell E. Family Interview for Genetic Studies. Clinical Neurogenetics Branch IRP, NIMH: Bethesda, MD, USA, 1992.
35. McGirr A, Alda M, Seguin M, Cabot S, Lesage A, Turecki G. Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder. Am J Psychiatry 2009; 166: 1124-1134.
36. Conner KR, Conwell Y, Duberstein PR. The validity of proxy-based data in suicide research: a study of patients 50 years of age and older who attempted suicide. II. Life events, social support and suicidal behavior. Acta Psychiatr Scand 2001; 104: 452-457.
37. Dumais A, Lesage AD, Alda M, Rouleau G, Dumont M, Chawky N et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry 2005; 162: 2116-2124.
38. Kelly TM, Mann JJ. Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with clinician ante-mortem diagnosis. Acta Psychiatr Scand 1996; 94: 337-343.
39. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 2010; 38: 576-589.
40. Wang D, Liu X, Zhou Y, Xie H, Hong X, Tsai HJ et al. Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Epigenetics 2012; 7: 594-605.
41. Schroeder JW, Conneely KN, Cubells JC, Kilaru V, Newport DJ, Knight BT et al. Neonatal DNA methylation patterns associate with gestational age. Epigenetics 2011; 6: 1498-1504.
42. Franz MB, Poterauer M, Elhenicky M, Stary S, Birner P, Vinatzer U et al. Global and single gene DNA methylation in umbilical cord blood cells after elective caesarean: a pilot study. Eur J Obstet Gynecol Reprod Biol 2014; 179: 121-124.
43. Joubert BR, Haberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK et al. 450 K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2012; 120: 1425-1431.
44. Provencal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D et al. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci 2012; 32: 15626-15642.
45. Non AL, Binder AM, Kubzansky LD, Michels KB. Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy. Epigenetics 2014; 9: 964-972.
46. Schroeder JW, Smith AK, Brennan PA, Conneely KN, Kilaru V, Knight BT et al. DNA methylation in neonates born to women receiving psychiatric care. Epigenetics 2012; 7: 409-414.
47. Adalsteinsson BT, Gudnason H, Aspelund T, Harris TB, Launer LJ, Eiriksdottir G et al. Heterogeneity in white blood cells has potential to confound DNA methylation measurements. PLoS One 2012; 7: e46705.
48. Reinius LE, Acevedo N, Joerink M, Pershagen G, Dahlen SE, Greco D et al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS One 2012; 7: e41361.
49. Zhi D, Aslibekyan S, Irvin MR, Claas SA, Borecki IB, Ordovas JM et al. SNPs located at CpG sites modulate genome-epigenome interaction. Epigenetics 2013; 8: 802-806.
50. Labonte B, Suderman M, Maussion G, Lopez JP, Navarro-Sanchez L, Yerko V et al. Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry 2013; 170: 511-520.