Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Devlin, Angela M ^a   Brain, Ursula ^a   Austin, Jehannine ^a   Oberlander, Tim F ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BRAIN DERIVED NEUROTROPHIC FACTOR; FOLIC ACID; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DNA METHYLATION; EDINBURGH POSTNATAL DEPRESSION SCALE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAMILTON SCALE; HUMAN; HUMAN CELL; INFANT; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MATERNAL BLOOD; PREGNANT WOMAN; PRENATAL EXPOSURE; SECOND TRIMESTER PREGNANCY; THIRD TRIMESTER PREGNANCY; UMBILICAL CORD BLOOD; BIRTH; ENVIRONMENTAL EXPOSURE; GENETICS; GENOTYPE; MOTHER; NEWBORN; NUCLEOTIDE SEQUENCE; PREGNANCY; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BASE SEQUENCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DNA METHYLATION; FEMALE; GENOTYPE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MATERNAL EXPOSURE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MOTHERS; PARTURITION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PROMOTER REGIONS, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 77957880665     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012201     Document Type: Article

References (43)

1. Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C (2006) Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 63: 898-906.
2. Oberlander TF, Papsdorf M, Brain U, Misri S, Ross C, et al. (2010) Prenatal influences of selective serotonin reuptake inhibitor (SSRI) antidepressants, serotonin transporter promoter genotype (SLC6A4) and maternal mood on child behavior at 3 years of age. Arch Pediatr Adolesc Med 164: 444-451.
3. O'Connor TG, Heron J, Golding J, Beveridge M, Glover V (2002) Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children. Br J Psychiatry 180: 502-508.
4. Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054.
5. Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 Suppl: 245-254.
6. Weaver ICG, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, et al. (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7: 847-854.
7. Oberlander T, Weinberg J, Papsdorf M, Grunau R, Misri S, et al. (2008) Prenatal exposure to maternal depression and methylation of human glucocorticoid receptor gene (NR3C1) in newborns. Epigenetics 3: 97-106.
8. Roth TL, Lubin FD, Funk AJ, Sweatt JD (2009) Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene. Biological Psychiatry 65: 760-769.
9. McGowan PO, Sasaki A, Huang TCT, Unterberger A, Suderman M, et al. (2008) Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain. PLoS ONE 3: e2085.
10. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, et al. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12: 342-348.
11. Whitaker-Azmitia PM, Druse M, Walker P, Lauder JM (1996) Serotonin as a developmental signal. Behav Brain Res 73: 19-29.
12. Jans LA, Riedel WJ, Markus CR, Blokland A (2007) Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry 12: 522-543.
13. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
14. Lesch KP, Mossner R (1998) Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 44: 179-192.
15. Heils A, Teufel A, Petri S, Stober G, Riederer P, et al. (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624.
16. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, et al. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301: 386-389.
17. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B (2005) The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62: 529-535.
18. Philibert R, Madan A, Andersen A, Cadoret R, Packer H, et al. (2007) Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am J Med Genet B Neuropsychiatr Genet 144: 101-105.
19. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111-113.
20. Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH (2006) Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr 83: 708-713.
21. Castro R, Rivera I, Ravasco P, Camilo ME, Jakobs C, et al. (2004) 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CRT and 1298ARC mutations are associated with DNA hypomethylation. J Med Genet 41: 454-458.
22. Sohn KJ, Jang H, Campan M, Weisenberger DJ, Dickhout J, et al. (2009) The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer 124: 1999-2005.
23. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, et al. (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 99: 5606-5611.
24. Almeida OP, McCaul K, Hankey GJ, Norman P, Jamrozik K, et al. (2008) Homocysteine and Depression in Later Life. Arch Gen Psychiatry 65: 1286-1294.
25. Lopez-Leon S, Janssens ACJW, Gonzalez-Zuloeta Ladd AM, Del-Favero J, et al. (2007) Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 13: 772-785.
26. Gilbody S, Lewis S, Lightfoot T (2007) Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review. Am J Epidemiol 165: 1-13.
27. Bjelland I, Tell GS, Vollset SE, Refsum H, Ueland PM (2003) Folate, Vitamin B12, Homocysteine, and the MTHFR 677CRT Polymorphism in Anxiety and Depression: The Hordaland Homocysteine Study. Arch Gen Psychiatry 60: 618-626.
28. Lewis SJ, Lawlor DA, vey Smith G, Araya R, Timpson N, et al. (2006) The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. Mol Psychiatry 11: 352-360.
29. Ansorge MS, Morelli E, Gingrich JA (2008) Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci 28: 199-207.
30. Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002-1012.
31. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA (2004) Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306: 879-881.
32. Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, et al. (2008) Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis. Am J Hum Genet 82: 696-711.
33. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, et al. (2006) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 27: 1834-1837.
34. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, et al. (2006) BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 59: 812-815.
35. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, et al. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93: 7-9.
36. Oberlander TF, Bonaguro RJ, Misri S, Papsdorf M, Ross CJD, et al. (2007) Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications. Mol Psychiatry 13: 65-73.
37. Oberlander TF, Grunau R, Mayes L, Riggs W, Rurak D, et al. (2008) Hypothalamic-pituitary-adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure. Early Hum Dev 84: 689-697.
38. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
39. Cox JL, Holden JM, Sagovsky R (1987) Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 150: 782-786.
40. Dupont JM, Tost J, Jammes H, Gut IG (2004) De novo quantitative bisulfite sequencing using the pyrosequencing technology. Anal Biochem 333: 119-127.
41. Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, et al. (2008) The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 147B: 543-549.
42. Mortensen OV, Thomassen M, Larsen MB, Whittemore SR, Wiborg O (1999) Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Molecular Brain Research 68: 141-148.
43. Lubin FD, Roth TL, Sweatt JD (2008) Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory. J Neurosci 28: 10576-10586.