Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway

Anti-Cancer Drugs

Volumn 25, Issue 9, 2014, Pages 1035-1043

  Li, Yi ^a   Zhang, Zhen Ni ^b   Zhao, Hong Mou ^a   Tong, Zhi Chao ^a   Yang, Jie ^a   Wang, Hu ^a   Liang, Xiao Jun ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Extracellular signal regulated kinase; Invasion; Matrine; Matrix metalloproteinase; NF B; Osteosarcoma

Indexed keywords

GELATINASE A; GELATINASE B; I KAPPA B; MATRINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P50; SYNAPTOTAGMIN I; ALKALOID; ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAPK1 PROTEIN, HUMAN; QUINOLIZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SAOS 2 CELL LINE; TUMOR INVASION; TUMOR XENOGRAFT; U2OS CELL LINE; ANIMAL; BAGG ALBINO MOUSE; BONE NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; NUDE MOUSE; OSTEOSARCOMA; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; HETEROGRAFTS; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; NF-KAPPA B; OSTEOSARCOMA; PHOSPHORYLATION; QUINOLIZINES; SIGNAL TRANSDUCTION;

EID: 84927163745     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000136     Document Type: Article

References (41)

1. Liang CZ, Zhang JK, Shi Z, Liu B, Shen CQ, Tao HM. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemother Pharmacol 2012; 69:317-331.
2. Wu PK, Chen WM, Chen CF, Lee OK, Haung CK, Chen TH. Primary osteogenic sarcoma with pulmonary metastasis: Clinical results and prognostic factors in 91 patients. Jpn J Clin Oncol 2009; 39:514-522.
3. Min D, Lin F, Shen Z, Zheng S, Tan L, Yu W, Yao Y. Analysis of prognostic factors in 333 Chinese patients with high-grade osteosarcoma treated by multidisciplinary combined therapy. Asia Pac J Clin Oncol 2013; 9:71-79.
4. Whelan JS, Jinks RC, McTiernan A, Sydes MR, Hook JM, Trani L, et al. Survival from high-grade localised extremity osteosarcoma: Combined results and prognostic factors from three European Osteosarcoma Intergroup randomised controlled trials. Ann Oncol 2012; 23:1607-1616.
5. Gialeli C, Theocharis AD, Karamanos NK. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 2011; 278:16-27.
6. Chen K, Zhang S, Ji Y, Li J, An P, Ren H, et al. Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. PLoS One 2013; 8:e72927.
7. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 1999; 18:813-822.
8. Lu KH, Yang HW, Su CW, Lue KH, Yang SF, Hsieh YS. Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. Food Chem Toxicol 2013; 52:193-199.
9. Tsubaki M, Satou T, Itoh T, Imano M, Ogaki M, Yanae M, Nishida S. Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/ MEK/ERK and Ras/PI3K/Akt pathway. Toxicol Appl Pharmacol 2012; 259:402-410.
10. Si H, Peng C, Li J, Wang X, Zhai L, Li X. RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. Int J Oncol 2012; 40:1291-1297.
11. Yang JS, Lin CW, Hsieh YS, Cheng HL, Lue KH, Yang SF, Lu KH. Selaginella tamariscina (Beauv.) possesses antimetastatic effects on human osteosarcoma cells by decreasing MMP-2 and MMP-9 secretions via p38 and Akt signaling pathways. Food Chem Toxicol 2013; 59:801-807.
12. Felx M, Guyot MC, Isler M, Turcotte RE, Doyon J, Khatib AM, et al. Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. Clin Sci (Lond) 2006; 110:645-654.
13. Ben-David D, Livne E, Reznick AZ. The involvement of oxidants and NFkappaB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Inflamm Res 2012; 61:673-688.
14. Li Y, Wang B, Zhou C, Bi Y. Matrine induces apoptosis in angiotensin IIstimulated hyperplasia of cardiac fibroblasts: effects on Bcl-2/Bax expression and caspase-3 activation. Basic Clin Pharmacol Toxicol 2007; 101:1-8.
15. Haiyan W, Yuxiang L, Linglu D, Tingting X, Yinju H, Hongyan L, et al. Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury. Pharm Biol 2013; 51:844-850.
16. Li X, Zhou R, Zheng P, Yan L, Wu Y, Xiao X, Dai G. Cardioprotective effect of matrine on isoproterenol-induced cardiotoxicity in rats. J Pharm Pharmacol 2010; 62:514-520.
17. Ma ZJ, Li Q, Wang JB, Zhao YL, Zhong YW, Bai YF, et al. Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the hepatitis B virus in vitro. Evid Based Complement Alternat Med 2013; 2013:186573.
18. Zhang X, Liu G, Kang Y, Dong Z, Qian Q, Ma X. N-Cadherin expression is associated with acquisition of EMT phenotype and with enhanced invasion in erlotinib-resistant lung cancer cell lines. PLoS One 2013; 8:e57692.
19. Guo L, Xue TY, Xu W, Gao JZ. Effects of matrine on the proliferation and apoptosis of human rhabdomyosarcoma RD cells. Zhongguo Dang Dai Er Ke Za Zhi 2012; 14:780-784.
20. Zhang S, Zhang Y, Zhuang Y, Wang J, Ye J, Wu J, et al. Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. PLoS One 2012; 7:e46853.
21. Zai H, Yi X, Li Y, Jiang C, Lu X. Simultaneous inhibition of XIAP and survivin expression on EMT and invasion of human pancreatic cancer cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012; 37:883-888.
22. Chiu YW, Lin TH, Huang WS, Teng CY, Liou YS, Kuo WH, et al. Baicalein inhibits the migration and invasive properties of human hepatoma cells. Toxicol Appl Pharmacol 2011; 255:316-326.
23. Zhao Z, Wu MS, Zou C, Tang Q, Lu J, Liu D, et al. Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-kappaB pathway. Cancer Lett 2014; 342:150-158.
24. Chen HJ, Lin CM, Lee CY, Shih NC, Peng SF, Tsuzuki M, et al. Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncol Rep 2013; 30:925-932.
25. Liang RR, Zhang S, Qi JA, Wang ZD, Li J, Liu PJ, et al. Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling. Int J Oncol 2012; 41:969-978.
26. Guo L, Xue TY, Xu W, Gao JZ. Matrine promotes G0/G1 arrest and down-regulates cyclin D1 expression in human rhabdomyosarcoma cells. Panminerva Med 2013; 55:291-296.
27. Chang C, Liu SP, Fang CH, He RS, Wang Z, Zhu YQ, Jiang SW. Effects of matrine on the proliferation of HT29 human colon cancer cells and its antitumor mechanism. Oncol Lett 2013; 6:699-704.
28. Shao H, Yang B, Hu R, Wang Y. Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NFkappaB signaling pathway. Oncol Lett 2013; 6:517-520.
29. Tan C, Qian X, Jia R, Wu M, Liang Z. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep 2013; 30:2529-2535.
30. Li H, Tan G, Jiang X, Qiao H, Pan S, Jiang H, et al. Therapeutic effects of matrine on primary and metastatic breast cancer. Am J Chin Med 2010; 38:1115-1130.
31. Yeh CB, Hsieh MJ, Hsieh YH, Chien MH, Chiou HL, Yang SF. Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity. PLoS One 2012; 7:e31055.
32. Yu HB, Zhang HF, Li DY, Zhang X, Xue HZ, Zhao SH. Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. J Asian Nat Prod Res 2011; 13:242-250.
33. Zhang W, Dai BT, Xu YH. Effects of matrine on invasion and metastasis of leukemia cell line Jurkat. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008; 28:907-911.
34. Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang G. Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology 2009; 59:219-229.
35. Lu KW, Chen JC, Lai TY, Yang JS, Weng SW, Ma YS, et al. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2-9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Hum Exp Toxicol 2011; 30:406-415.
36. Liu SQ, Huang JA, Qin MB, Su YJ, Lai MY, Jiang HX, Tang GD. Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. Int J Colorectal Dis 2012; 27:1569-1578.
37. Luo C, Zhong HJ, Zhu LM, Wu XG, Ying JE, Wang XH, et al. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep 2012; 39:5459-5464.
38. Che Q, Liu BY, Wang FY, He YY, Lu W, Liao Y, et al. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK-NF-kappaB signaling pathway. Biochem Biophys Res Commun 2014; 446:167-172.
39. Zhang J, Zhang Y, Liu S, Zhang Q, Wang Y, Tong L, et al. Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-kappaB pathway. Tumour Biol 2013; 34:2433-2440.
40. Wang X, Wang Q, Hu W, Evers BM. Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB- dependent pathway. Oncogene 2004; 23:1885-1895.
41. Huang CY, Lee CY, Chen MY, Yang WH, Chen YH, Chang CH, et al. Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. J Cell Physiol 2009; 221:204-212.