The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9500-9510

  Bhattacharjee, Arnab ^a,b,g   Reuter, Stefanie ^c   Trojnár, Eszter ^d   Kolodziejczyk, Robert ^b   Hyvärinen, Harald Seeberger Satu ^a   Uzonyi, Barbara ^e   Szilágyi, Ágnes ^d   Prohászka, Zoltán ^d   Goldman, Adrian ^b   Józsi, Mihály ^c,f   Jokiranta, T Sakari ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HANS KNÖLL INSTITUTE   (Germany)

^d SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^e MTA ELTE Immunology Research Group Eötvös University   (Hungary)

^f EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^g UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DISEASES; PROTEINS;

AUTOANTIBODIES; C-TERMINAL DOMAINS; HOST CELLS; MICROBIAL PROTEINS; SIALIC ACIDS; STRUCTURAL DIFFERENCES;

EPITOPES;

AUTOANTIBODY; BINDING PROTEIN; COMPLEMENT FACTOR H; COMPLEMENT FACTOR H RELATED PROTEIN 1; EPITOPE; UNCLASSIFIED DRUG; CFHR1 PROTEIN, HUMAN; COMPLEMENT FACTOR I; PEPTIDE FRAGMENT; PROTEIN BINDING;

ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HEMOLYTIC UREMIC SYNDROME; HUMAN; MUTANT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; EPITOPE MAPPING; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ATYPICAL HEMOLYTIC UREMIC SYNDROME; AUTOANTIBODIES; AUTOIMMUNITY; BINDING SITES; COMPLEMENT C3B INACTIVATOR PROTEINS; COMPLEMENT FACTOR H; CRYSTALLOGRAPHY, X-RAY; EPITOPE MAPPING; EPITOPES; HUMANS; MODELS, MOLECULAR; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84927156913     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.630871     Document Type: Article

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