Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d

Molecular Immunology

Volumn 47, Issue 9, 2010, Pages 1686-1691

  Bhattacharjee, Arnab ^a,b   Lehtinen, Markus J ^a   Kajander, Tommi ^b   Goldman, Adrian ^b   Jokiranta, T Sakari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Alternative complement pathway; Atypical haemolytic uremic syndrome; C3b; C3d; CFH; Factor H; Opsonisation; Structural biology; X ray crystallography

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3D; COMPLEMENT FACTOR H; MUTANT PROTEIN;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT FIXATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; GENE MUTATION; HEMOLYTIC UREMIC SYNDROME; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; BINDING SITES; COMPLEMENT C3B; COMPLEMENT C3D; COMPLEMENT FACTOR H; CRYSTALLOGRAPHY, X-RAY; HEMOLYTIC-UREMIC SYNDROME; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 77952322658     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.03.007     Document Type: Article

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