메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; INTERLEUKIN 33; MICRORNA 29A; PROTEIN ST2; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; IL1RL1 PROTEIN, HUMAN; IL33 PROTEIN, HUMAN; INTERLEUKIN 1BETA; LUCIFERASE; MICRORNA; MIRN29 MICRORNA, HUMAN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84927145585     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7774     Document Type: Article
Times cited : (139)

References (54)
  • 1
    • 33847020833 scopus 로고    scopus 로고
    • Inflammation in wound repair: Molecular and cellular mechanisms
    • Eming, S. A., Krieg, T. & Davidson, J. M. Inflammation in wound repair: molecular and cellular mechanisms. J. Invest. Dermatol. 127, 514-525 (2007).
    • (2007) J. Invest. Dermatol. , vol.127 , pp. 514-525
    • Eming, S.A.1    Krieg, T.2    Davidson, J.M.3
  • 2
    • 0029007793 scopus 로고
    • Assessing health needs in primary care. Morbidity study from general practice provides another source of information
    • McCormick, A., Charlton, J. & Fleming, D. Assessing health needs in primary care. Morbidity study from general practice provides another source of information. BMJ 310, 1534 (1995).
    • (1995) BMJ , vol.310 , pp. 1534
    • McCormick, A.1    Charlton, J.2    Fleming, D.3
  • 3
    • 0032785647 scopus 로고    scopus 로고
    • Histopathology of common tendinopathies. Update and clinical management
    • Khan, K. M., Cook, J. L., Bomar, F., Harcourt, P. & Astrom, M. Histopathology of common tendinopathies. Update and clinical management Sports Med 27, 393-408 (1999).
    • (1999) Sports Med , vol.27 , pp. 393-408
    • Khan, K.M.1    Cook, J.L.2    Bomar, F.3    Harcourt, P.4    Astrom, M.5
  • 4
    • 11844274558 scopus 로고    scopus 로고
    • Tendon injury and tendinopathy: Healing and repair
    • Sharma, P. & Maffulli, N. Tendon injury and tendinopathy: healing and repair. J. Bone Joint Surg. Am. 87, 187-202 (2005).
    • (2005) J. Bone Joint Surg. Am. , vol.87 , pp. 187-202
    • Sharma, P.1    Maffulli, N.2
  • 6
    • 0034815447 scopus 로고    scopus 로고
    • The angiogenic peptide vascular endothelial growth factor is expressed in foetal and ruptured tendons
    • Pufe, T., Petersen, W., Tillmann, B. & Mentlein, R. The angiogenic peptide vascular endothelial growth factor is expressed in foetal and ruptured tendons. Virchows Arch. 439, 579-585 (2001).
    • (2001) Virchows Arch , vol.439 , pp. 579-585
    • Pufe, T.1    Petersen, W.2    Tillmann, B.3    Mentlein, R.4
  • 7
    • 0037228988 scopus 로고    scopus 로고
    • IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells
    • Tsuzaki, M. et al. IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. J. Orthop. Res. 21, 256-264 (2003).
    • (2003) J. Orthop. Res. , vol.21 , pp. 256-264
    • Tsuzaki, M.1
  • 8
    • 35948977011 scopus 로고    scopus 로고
    • The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1beta are different from those of normal tendon fibroblasts
    • Tohyama, H., Yasuda, K., Uchida, H. & Nishihira, J. The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1beta are different from those of normal tendon fibroblasts. J. Bone Joint Surg. Br. 89, 1261-1267 (2007).
    • (2007) J. Bone Joint Surg. Br. , vol.89 , pp. 1261-1267
    • Tohyama, H.1    Yasuda, K.2    Uchida, H.3    Nishihira, J.4
  • 9
    • 77954728890 scopus 로고    scopus 로고
    • Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes
    • John, T. et al. Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes. J. Orthop. Res. 28, 1071-1077 (2010).
    • (2010) J. Orthop. Res. , vol.28 , pp. 1071-1077
    • John, T.1
  • 10
    • 27744469758 scopus 로고    scopus 로고
    • Tendon healing in interleukin-4 and interleukin-6 knockout mice
    • Lin, T. W., Cardenas, L., Glaser, D. L. & Soslowsky, L. J. Tendon healing in interleukin-4 and interleukin-6 knockout mice. J. Biomech. 39, 61-69 (2006).
    • (2006) J. Biomech. , vol.39 , pp. 61-69
    • Lin, T.W.1    Cardenas, L.2    Glaser, D.L.3    Soslowsky, L.J.4
  • 11
    • 80053301136 scopus 로고    scopus 로고
    • Evaluation of tumor necrosis factor alpha blockade on early tendon-to-bone healing in a rat rotator cuff repair model
    • Gulotta, L. V., Kovacevic, D., Cordasco, F. & Rodeo, S. A. Evaluation of tumor necrosis factor alpha blockade on early tendon-to-bone healing in a rat rotator cuff repair model. Arthroscopy 27, 1351-1357 (2011).
    • (2011) Arthroscopy , vol.27 , pp. 1351-1357
    • Gulotta, L.V.1    Kovacevic, D.2    Cordasco, F.3    Rodeo, S.A.4
  • 12
    • 27744446058 scopus 로고    scopus 로고
    • IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    • Schmitz, J. et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23, 479-490 (2005).
    • (2005) Immunity , vol.23 , pp. 479-490
    • Schmitz, J.1
  • 13
    • 84857134135 scopus 로고    scopus 로고
    • IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
    • Lefrancais, E. et al. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc. Natl Acad. Sci. USA 109, 1673-1678 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 1673-1678
    • Lefrancais, E.1
  • 14
    • 84857484469 scopus 로고    scopus 로고
    • Interleukin 33 as a mechanically responsive cytokine secreted by living cells
    • Kakkar, R., Hei, H., Dobner, S. & Lee, R. T. Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J. Biol. Chem. 287, 6941-6948 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 6941-6948
    • Kakkar, R.1    Hei, H.2    Dobner, S.3    Lee, R.T.4
  • 15
    • 68249143387 scopus 로고    scopus 로고
    • IL-33 raises alarm
    • Lamkanfi, M. & Dixit, V. M. IL-33 raises alarm. Immunity 31, 5-7 (2009).
    • (2009) Immunity , vol.31 , pp. 5-7
    • Lamkanfi, M.1    Dixit, V.M.2
  • 16
    • 75549087056 scopus 로고    scopus 로고
    • Disease-associated functions of IL-33: The new kid in the IL-1 family
    • Liew, F. Y., Pitman, N. I. & McInnes, I. B. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat. Rev. Immunol. 10, 103-110 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 103-110
    • Liew, F.Y.1    Pitman, N.I.2    McInnes, I.B.3
  • 18
    • 84859892863 scopus 로고    scopus 로고
    • MicroRNA profiling: Approaches and considerations
    • Pritchard, C. C., Cheng, H. H. & Tewari, M. MicroRNA profiling: approaches and considerations. Nat. Rev. Genet. 13, 358-369 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 358-369
    • Pritchard, C.C.1    Cheng, H.H.2    Tewari, M.3
  • 19
    • 49449111630 scopus 로고    scopus 로고
    • IL-33 exacerbates antigen-induced arthritis by activating mast cells
    • Xu, D. et al. IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc. Natl Acad. Sci. USA 105, 10913-10918 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 10913-10918
    • Xu, D.1
  • 20
    • 79958073057 scopus 로고    scopus 로고
    • IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss
    • Zaiss, M. M. et al. IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss. J. Immunol. 186, 6097-6105 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 6097-6105
    • Zaiss, M.M.1
  • 21
    • 77949311799 scopus 로고    scopus 로고
    • IL-33 induces IL-13-dependent cutaneous fibrosis
    • Rankin, A. L. et al. IL-33 induces IL-13-dependent cutaneous fibrosis. J. Immunol. 184, 1526-1535 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 1526-1535
    • Rankin, A.L.1
  • 22
    • 33646194371 scopus 로고    scopus 로고
    • Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases
    • Matthews, T. J., Hand, G. C., Rees, J. L., Athanasou, N. A. & Carr, A. J. Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases. J. Bone Joint Surg. Br. 88, 489-495 (2006).
    • (2006) J. Bone Joint Surg. Br. , vol.88 , pp. 489-495
    • Matthews, T.J.1    Hand, G.C.2    Rees, J.L.3    Athanasou, N.A.4    Carr, A.J.5
  • 23
    • 77958194570 scopus 로고    scopus 로고
    • Inflammation is present in early human tendinopathy
    • Millar, N. L. et al. Inflammation is present in early human tendinopathy. Am. J. Sports Med. 38, 2085-2091 (2010).
    • (2010) Am. J. Sports Med. , vol.38 , pp. 2085-2091
    • Millar, N.L.1
  • 24
    • 72949109956 scopus 로고    scopus 로고
    • Suppression of type I collagen production by microRNA-29b in cultured human stellate cells
    • Ogawa, T. et al. Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem. Biophys. Res. Commun. 391, 316-321 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 316-321
    • Ogawa, T.1
  • 25
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 26
    • 80052033649 scopus 로고    scopus 로고
    • The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma
    • Ma, F. et al. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat. Immunol. 12, 861-869 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 861-869
    • Ma, F.1
  • 27
    • 34250805982 scopus 로고    scopus 로고
    • MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
    • Grimson, A. et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27, 91-105 (2007).
    • (2007) Mol. Cell , vol.27 , pp. 91-105
    • Grimson, A.1
  • 28
    • 77952946050 scopus 로고    scopus 로고
    • MicroRNA-29, a key regulator of collagen expression in systemic sclerosis
    • Maurer, B. et al. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum. 62, 1733-1743 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1733-1743
    • Maurer, B.1
  • 29
    • 80052979140 scopus 로고    scopus 로고
    • Mechanisms and consequences of alternative polyadenylation
    • Di Giammartino, D. C., Nishida, K. & Manley, J. L. Mechanisms and consequences of alternative polyadenylation. Mol. Cell 43, 853-866 (2011).
    • (2011) Mol. Cell , vol.43 , pp. 853-866
    • Di Giammartino, D.C.1    Nishida, K.2    Manley, J.L.3
  • 30
    • 0033747044 scopus 로고    scopus 로고
    • Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
    • Basu, S., Binder, R. J., Suto, R., Anderson, K. M. & Srivastava, P. K. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int. Immunol. 12, 1539-1546 (2000).
    • (2000) Int. Immunol. , vol.12 , pp. 1539-1546
    • Basu, S.1    Binder, R.J.2    Suto, R.3    Anderson, K.M.4    Srivastava, P.K.5
  • 31
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi, P., Misteli, T. & Bianchi, M. E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195 (2002).
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 32
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003).
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 33
    • 34447116244 scopus 로고    scopus 로고
    • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    • Chen, C. J. et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat. Med. 13, 851-856 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 851-856
    • Chen, C.J.1
  • 34
    • 58849151813 scopus 로고    scopus 로고
    • Cutting edge: Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells
    • Eigenbrod, T., Park, J. H., Harder, J., Iwakura, Y. & Nunez, G. Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J. Immunol. 181, 8194-8198 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8194-8198
    • Eigenbrod, T.1    Park, J.H.2    Harder, J.3    Iwakura, Y.4    Nunez, G.5
  • 35
    • 53749093767 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: A novel 'alarmin'?
    • Moussion, C., Ortega, N. & Girard, J. P. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS ONE 3, e3331 (2008).
    • (2008) PLoS ONE , vol.3 , pp. e3331
    • Moussion, C.1    Ortega, N.2    Girard, J.P.3
  • 36
    • 67049158193 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    • Cayrol, C. & Girard, J. P. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc. Natl Acad. Sci. USA 106, 9021-9026 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9021-9026
    • Cayrol, C.1    Girard, J.P.2
  • 37
    • 38849090654 scopus 로고    scopus 로고
    • Tendon: Biology, biomechanics, repair, growth factors, and evolving treatment options
    • James, R., Kesturu, G., Balian, G. & Chhabra, A. B. Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options. J. Hand Surg. Am. 33, 102-112 (2008).
    • (2008) J. Hand Surg. Am. , vol.33 , pp. 102-112
    • James, R.1    Kesturu, G.2    Balian, G.3    Chhabra, A.B.4
  • 38
    • 67651087321 scopus 로고    scopus 로고
    • Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
    • Brown, B. D. & Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat. Rev. Genet. 10, 578-585 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 578-585
    • Brown, B.D.1    Naldini, L.2
  • 39
    • 84887207559 scopus 로고    scopus 로고
    • Extracellular matrix secretion by cardiac fibroblasts: Role of microRNA-29b and microRNA-30c
    • Abonnenc, M. et al. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113, 1138-1147 (2013).
    • (2013) Circ. Res. , vol.113 , pp. 1138-1147
    • Abonnenc, M.1
  • 40
    • 78751476297 scopus 로고    scopus 로고
    • Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
    • Roderburg, C. et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology 53, 209-218 (2011).
    • (2011) Hepatology , vol.53 , pp. 209-218
    • Roderburg, C.1
  • 41
    • 44449111693 scopus 로고    scopus 로고
    • MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
    • Sengupta, S. et al. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc. Natl Acad. Sci. USA 105, 5874-5878 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 5874-5878
    • Sengupta, S.1
  • 42
    • 84876313527 scopus 로고    scopus 로고
    • Polymorphisms within the COL5A1 3'-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy
    • Abrahams, Y., Laguette, M. J., Prince, S. & Collins, M. Polymorphisms within the COL5A1 3'-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy. Ann. Hum. Genet. 77, 204-214 (2013).
    • (2013) Ann. Hum. Genet. , vol.77 , pp. 204-214
    • Abrahams, Y.1    Laguette, M.J.2    Prince, S.3    Collins, M.4
  • 43
    • 84863301940 scopus 로고    scopus 로고
    • Mechanical loading and TGF-beta change the expression of multiple miRNAs in tendon fibroblasts
    • Mendias, C. L., Gumucio, J. P. & Lynch, E. B. Mechanical loading and TGF-beta change the expression of multiple miRNAs in tendon fibroblasts. J. Appl. Physiol. (1985) 113, 56-62 (2012).
    • (2012) J. Appl. Physiol. (1985) , vol.113 , pp. 56-62
    • Mendias, C.L.1    Gumucio, J.P.2    Lynch, E.B.3
  • 44
    • 80051655553 scopus 로고    scopus 로고
    • miR-29 is a major regulator of genes associated with pulmonary fibrosis
    • Cushing, L. et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 45, 287-294 (2011).
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.45 , pp. 287-294
    • Cushing, L.1
  • 45
    • 84879667833 scopus 로고    scopus 로고
    • miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development
    • Wei, W. et al. miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development. Cell Death Dis. 4, e668 (2013).
    • (2013) Cell Death Dis. , vol.4 , pp. e668
    • Wei, W.1
  • 46
    • 84855344980 scopus 로고    scopus 로고
    • Hypoxia: A critical regulator of early human tendinopathy
    • Millar, N. L. et al. Hypoxia: a critical regulator of early human tendinopathy. Ann. Rheum. Dis. 71, 302-310 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 302-310
    • Millar, N.L.1
  • 49
    • 10244253892 scopus 로고    scopus 로고
    • Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients
    • McInnes, I. B. et al. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J. Exp. Med. 184, 1519-1524 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 1519-1524
    • McInnes, I.B.1
  • 51
    • 0032785647 scopus 로고    scopus 로고
    • Histopathology of common tendinopathies. Update and implications for clinical management
    • Khan, K. M., Cook, J. L., Bonar, F., Harcourt, P. & Astrom, M. Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med. 27, 393-408 (1999).
    • (1999) Sports Med , vol.27 , pp. 393-408
    • Khan, K.M.1    Cook, J.L.2    Bonar, F.3    Harcourt, P.4    Astrom, M.5
  • 52
    • 58149300244 scopus 로고    scopus 로고
    • IL-33 induces antigen-specific IL-5 + T cells and promotes allergic-induced airway inflammation independent of IL-4
    • Kurowska-Stolarska, M. et al. IL-33 induces antigen-specific IL-5 + T cells and promotes allergic-induced airway inflammation independent of IL-4. J. Immunol. 181, 4780-4790 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4780-4790
    • Kurowska-Stolarska, M.1
  • 53
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng, Y. et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651 (2007).
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1
  • 54
    • 68849104003 scopus 로고    scopus 로고
    • CCR6 is required for IL-23-induced psoriasis-like inflammation in mice
    • Hedrick, M. N. et al. CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J. Clin. Invest. 119, 2317-2329 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 2317-2329
    • Hedrick, M.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.