Inflammation is present in early human tendinopathy

American Journal of Sports Medicine

Volumn 38, Issue 10, 2010, Pages 2085-2091

  Millar, Neal L ^a   Hueber, Axel J ^a   Reilly, James H ^a   Yinghua Xu, ^b   Fazzi, Umberto G ^c   Murrell, George A C ^b   McInnes, Iain B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c WESTERN INFIRMARY   (United Kingdom)

Author keywords

inflammation; shoulder; supraspinatus; tendinopathy

Indexed keywords

AUTACOID;

ADULT; AGED; ARTICLE; BIOLOGICAL MODEL; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; SHOULDER; TENDINITIS;

ADULT; AGED; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; MIDDLE AGED; MODELS, BIOLOGICAL; SHOULDER; TENDINOPATHY; YOUNG ADULT;

EID: 77958194570     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546510372613     Document Type: Article

References (42)

1. Abate M., Gravare-Silbernagel K., Siljeholm C., et al. Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther. 2009 ; 11 (3). 235.
2. Almekinders LC, Temple JD Etiology, diagnosis, and treatment of tendonitis: an analysis of the literature. Med Sci Sports Exerc. 1998 ; 30 (8). 1183-1190.
3. Archambault J., Tsuzaki M., Herzog W., Banes AJ Stretch and interleukin-1beta induce matrix metalloproteinases in rabbit tendon cells in vitro. J Orthop Res. 2002 ; 20 (1). 36-39.
4. Barbe MF, Barr AE, Gorzelany I., Amin M., Gaughan JP, Safadi FF Chronic repetitive reaching and grasping results in decreased motor performance and widespread tissue responses in a rat model of MSD. J Orthop Res. 2003 ; 21 (1). 167-176.
5. Bisset L., Beller E., Jull G., Brooks P., Darnell R., Vicenzino B. Mobilisation with movement and exercise, corticosteroid injection, or wait and see for tennis elbow: randomised trial. BMJ. 2006 ; 333 (7575). 939.
6. Chuen FS, Chuk CY, Ping WY, Nar WW, Kim HL, Ming CK Immunohistochemical characterization of cells in adult human patellar tendons. J Histochem Cytochem. 2004 ; 52 (9). 1151-1157.
7. Clancy WG Jr, Neidhart D., Brand RL Achilles tendonitis in runners: a report of five cases. Am J Sports Med. 1976 ; 4 (2). 46-57.
8. Crivellato E., Travan L., Ribatti D. Mast cells and basophils: a potential link in promoting angiogenesis during allergic inflammation. Int Arch Allergy Immunol. 2010 ; 151 (2). 89-97.
9. Cummins CA, Murrell GA Mode of failure for rotator cuff repair with suture anchors identified at revision surgery. J Shoulder Elbow Surg. 2003 ; 12 (2). 128-133.
10. Damsgaard TE, Olesen AB, Sorensen FB, Thestrup-Pedersen K., Schiotz PO Mast cells and atopic dermatitis: stereological quantification of mast cells in atopic dermatitis and normal human skin. Arch Dermatol Res. 1997 ; 289 (5). 256-260.
11. Fu SC, Wang W., Pau HM, Wong YP, Chan KM, Rolf CG Increased expression of transforming growth factor-beta1 in patellar tendinosis. Clin Orthop Relat Res. 2002 ; 400: 174-183.
12. Glaros T., Larsen M., Li L. Macrophages and fibroblasts during inflammation, tissue damage and organ injury. Front Biosci. 2009 ; 14: 3988-3993.
13. Gruber BL Mast cells in scleroderma. Clin Dermatol. 1994 ; 12 (3). 397-406.
14. Hakim-Rad K., Metz M., Maurer M. Mast cells: makers and breakers of allergic inflammation. Curr Opin Allergy Clin Immunol. 2009 ; 9 (5). 427-430.
15. Hart DA, Frank CB, Kydd A., Ivie T., Sciore P., Reno C. Neurogenic, mast cell and gender variables in tendon biology: potential role in chronic tendinopathy. In Tendon Injuries. London: Springer. 2005: 40-48.
16. Hashimoto T., Nobuhara K., Hamada T. Pathologic evidence of degeneration as a primary cause of rotator cuff tear. Clin Orthop Relat Res. 2003 ; 415: 111-120.
17. Herring SA, Nilson KL Introduction to overuse injuries. Clin Sports Med. 1987 ; 6 (2). 225-239.
18. Kannus P., Jozsa L. Histopathological changes preceding spontaneous rupture of a tendon: a controlled study of 891 patients. J Bone Joint Surg Am. 1991 ; 73 (10). 1507-1525.
19. Khan KM, Cook JL, Bonar F., Harcourt P., Astrom M. Histopathology of common tendinopathies: update and implications for clinical management. Sports Med. 1999 ; 27 (6). 393-408.
20. Lian O., Scott A., Engebretsen L., Bahr R., Duronio V., Khan K. Excessive apoptosis in patellar tendinopathy in athletes. Am J Sports Med. 2007 ; 35 (4). 605-611.
21. Maffulli N., Barrass V., Ewen SW Light microscopic histology of Achilles tendon ruptures: a comparison with unruptured tendons. Am J Sports Med. 2000 ; 28: 857-863.
22. Maffulli N., Wong J., Almekinders LC Types and epidemiology of tendinopathy. Clin Sports Med. 2003 ; 22 (4). 675-692.
23. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002 ; 23 (11). 549-555.
24. Marr CM, McMillan I., Boyd JS, Wright NG, Murray M. Ultrasonographic and histopathological findings in equine superficial digital flexor tendon injury. Equine Vet J. 1993 ; 25 (1). 23-29.
25. Matthews TJ, Hand GC, Rees JL, Athanasou NA, Carr AJ Pathology of the torn rotator cuff tendon: reduction in potential for repair as tear size increases. J Bone Joint Surg Br. 2006 ; 88 (4). 489-495.
26. Matzinger P. Friendly and dangerous signals: is the tissue in control? Nat Immunol. 2007 ; 8 (1). 11-13.
27. McInnes IB Leukotrienes, mast cells, and T cells. Arthritis Res Ther. 2003 ; 5 (6). 288-289.
28. McInnes IB, Leung BP, Field M., et al. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med. 1996 ; 184 (4). 1519-1524.
29. Millar NL, Wei AQ, Molloy TJ, Bonar F., Murrell GA Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg Br. 2009 ; 91 (3). 417-424.
30. Millar NL, Wei AQ, Molloy TJ, Bonar F., Murrell GA Heat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res. 2008 ; 466 (7). 1569-1576.
31. Molloy TJ, Kemp MW, Wang Y., Murrell GA Microarray analysis of the tendinopathic rat supraspinatus tendon: glutamate signaling and its potential role in tendon degeneration. J Appl Physiol. 2006 ; 101 (6). 1702-1709.
32. Pearce CJ, Ismail M., Calder JD Is apoptosis the cause of noninsertional Achilles tendinopathy ? Am J Sports Med. 2009 ; 37: 2440-2444.
33. Perry SM, McIlhenny SE, Hoffman MC, Soslowsky LJ Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg. 2005 ; 14 (1 Suppl S). 79S - 83S.
34. Ricardo SD, van Goor H., Eddy AA Macrophage diversity in renal injury and repair. J Clin Invest. 2008 ; 118 (11). 3522-3530.
35. Ruffell D., Mourkioti F., Gambardella A., et al. A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci U S A. 2009 ; 106 (41). 17475-17480.
36. Scott A., Lian O., Bahr R., Hart DA, Duronio V., Khan KM Increased mast cell numbers in human patellar tendinosis: correlation with symptom duration and vascular hyperplasia. Br J Sports Med. 2008 ; 42 (9). 753-757.
37. Theoharides TC, Kalogeromitros D. The critical role of mast cells in allergy and inflammation. Ann N Y Acad Sci. 2006 ; 1088: 78-99.
38. Tsuzaki M., Guyton G., Garrett W., et al. IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. J Orthop Res. 2003 ; 21 (2). 256-264.
39. Uhthoff HK, Sano H. Pathology of failure of the rotator cuff tendon. Orthop Clin North Am. 1997 ; 28 (1). 31-41.
40. Wu X., Baldwick C., Murrell GAC. Arthroscopic undersurface rotator cuff repair. Tech Shoulder Elbow Surg. 2009 ; 10 (3). 112-118.
41. Yang G., Im HJ, Wang JH Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene. 2005 ; 363: 166-172.
42. Yuan J., Wang MX, Murrell GA Cell death and tendinopathy. Clin Sports Med. 2003 ; 22 (4). 693-701.