A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2

Cell Cycle

Volumn 14, Issue 2, 2015, Pages 179-188

  ElSawy, Karim M ^a,b   Sim, Adelene ^c   Lane, David P ^f   Verma, Chandra S ^c,d,e   Caves, Leo S D ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b QASSIM UNIVERSITY   (Saudi Arabia)

^c BIOINFORMATICS INSTITUTE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f AGENCY FOR SCIENCE   (Singapore)

Author keywords

Brownian dynamics simulation; Encounter complex; MDM2 protein; p53 phosphorylation; Residence time

Indexed keywords

PEPTIDE; PROTEIN MDM2; PROTEIN P53; PROTEIN BINDING;

ARTICLE; BINDING SITE; DYNAMICS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIMULATION; WILD TYPE; CHEMISTRY; HUMAN; KINETICS; METABOLISM; MOLECULAR DYNAMICS; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; MOLECULAR DYNAMICS SIMULATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; STATIC ELECTRICITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84927129239     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/15384101.2014.989043     Document Type: Article

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