Modulation of p53 binding to MDM2: Computational studies reveal important roles of Tyr100

BMC Bioinformatics

Volumn 10, Issue SUPPL. 15, 2009, Pages

  Dastidar, Shubhra G ^a   Lane, David P ^b   Verma, Chandra S ^a,c,d  

^a BIOINFORMATICS INSTITUTE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BINS; CONFORMATIONS; HYDROGEN BONDS; LIGANDS; PEPTIDES; PROTEINS; TUMORS; DIGITAL STORAGE; MOLECULAR DYNAMICS;

COMPLEX FORMATIONS; COMPUTATIONAL STUDIES; CONFORMATIONAL MOBILITY; HYDROPHOBIC RESIDUES; MOLECULAR DYNAMICS SIMULATIONS; NEAR-NATIVE CONFORMATIONS; THERAPEUTIC STRATEGY; TUMOR SUPPRESSOR PROTEINS; BINDING POCKETS; INTERCONVERSIONS; LIGAND BINDING; N-TERMINALS; NATIVE CONFORMATION; SIDE-CHAINS; SMALL MOLECULES; TWO-STATE; UBIQUITIN LIGASES;

MOLECULAR DYNAMICS; BIOINFORMATICS;

PROTEIN MDM2; PROTEIN P53; LIGAND; TYROSINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PROTEIN BINDING; PROTEIN CONFORMATION; SIMULATION; STRUCTURAL BIOINFORMATICS; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM;

PYRONIA TITHONUS;

BINDING SITES; COMPUTATIONAL BIOLOGY; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; TYROSINE;

EID: 71549116815     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-10-S15-S6     Document Type: Article

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