Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod

Journal of Dermatological Science

Volumn 76, Issue 1, 2014, Pages 67-69

  Ogawa, Youichi ^a   Kawamura, Tatsuyoshi ^a   Matsuzawa, Takamitsu ^a   Aoki, Rui ^a   Shimada, Shinji ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Actinic keratosis; IFN ; Imiquimod; Plasmacytoid dendritic cells; TLR7

Indexed keywords

ALPHA INTERFERON; CRYOPYRIN; FAS LIGAND; IMIQUIMOD; PERFORIN; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; AMINOQUINOLINE DERIVATIVE; CYTOKINE; IMMUNOLOGICAL ADJUVANT; MESSENGER RNA; TLR7 PROTEIN, HUMAN;

ACTINIC KERATOSIS; CELL INFILTRATION; CHEMOTAXIS; CLINICAL ARTICLE; DISEASE SEVERITY; DRUG RESPONSE; ERYTHEMA; HEALING; HISTOPATHOLOGY; HUMAN; INFLAMMATION; LETTER; PLASMACYTOID DENDRITIC CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SKIN BIOPSY; BIOPSY; CYTOLOGY; DENDRITIC CELL; DRUG EFFECTS; KERATOSIS, ACTINIC; METABOLISM; WOUND HEALING;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; BIOPSY; CYTOKINES; DENDRITIC CELLS; HUMANS; INFLAMMATION; INTERFERON-ALPHA; KERATOSIS, ACTINIC; RNA, MESSENGER; SKIN; TOLL-LIKE RECEPTOR 7; WOUND HEALING;

EID: 84922403550     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2014.07.004     Document Type: Letter

References (10)

1. Lebwohl M., Dinehart S., Whiting D., Lee P.K., Tawfik N., Jorizzo J., et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004, 50:714-721.
2. Jorizzo J., Dinehart S., Matheson R., Moore J.K., Ling M., Fox T.L., et al. Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head. J Am Acad Dermatol 2007, 57:265-268.
3. Torres A., Storey L., Anders M., Miller R.L., Bulbulian B.J., Jin J., et al. Microarray analysis of aberrant gene expression in actinic keratosis: effect of the Toll-like receptor-7 agonist imiquimod. Br J Dermatol 2007, 157:1132-1147.
4. Walter A., Schafer M., Cecconi V., Matter C., Urosevic-Maiwald M., Belloni B., et al. Aldara activates TLR7-independent immune defence. Nat Commun 2013, 4:1560.
5. Treilleux I., Blay J.Y., Bendriss-Vermare N., Ray-Coquard I., Bachelot T., Guastalla J.P., et al. Dendritic cell infiltration and prognosis of early stage breast cancer. Clin Cancer Res 2004, 10:7466-7474.
6. Stary G., Bangert C., Tauber M., Strohal R., Kopp T., Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med 2007, 204:1441-1451.
7. Drobits B., Holcmann M., Amberg N., Swiecki M., Grundtner R., Hammer M., et al. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest 2012, 122:575-585.
8. Urosevic M., Dummer R., Conrad C., Beyeler M., Laine E., Burg G., et al. Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment. J Natl Cancer Inst 2005, 97:1143-1153.
9. Kalb M.L., Glaser A., Stary G., Koszik F., Stingl G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J Immunol 2012, 188:1583-1591.
10. Kanneganti T.D., Ozoren N., Body-Malapel M., Amer A., Park J.H., Franchi L., et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 2006, 440:233-236.