F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins

European Journal of Immunology

Volumn 45, Issue 4, 2015, Pages 1248-1257

  Abualrous, Esam T ^a,b   Fritzsche, Susanne ^a   Hein, Zeynep ^a   Al Balushi, Mohammed S ^a,c   Reinink, Peter ^a,d   Boyle, Louise H ^e   Wellbrock, Ursula ^a   Antoniou, Antony N ^f   Springer, Sebastian ^a  

^a JACOBS UNIVERSITY BREMEN   (Germany)

^b Ain Shams University   (Egypt)

^c SULTAN QABOOS UNIVERSITY   (Oman)

^d UTRECHT UNIVERSITY   (Netherlands)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF EAST LONDON   (United Kingdom)

Author keywords

Ankylosing spondylitis; HLA B27; Major histocompatibility complex; Molecular dynamics; Natively unstructured proteins; Protein folding; Simulations

Indexed keywords

HLA B27 ANTIGEN; TAPASIN; CARRIER PROTEIN; CHAPERONE; HLA-B*27:05 ANTIGEN; HLA-B*27:09 ANTIGEN; PROTEIN BINDING;

ALLOTYPE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; FLOW CYTOMETRY; HYDROGEN BOND; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON TRANSPORT; ANIMAL; ANKYLOSING SPONDYLITIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN FOLDING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; HLA-B27 ANTIGEN; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; SEQUENCE ANALYSIS, DNA; SPONDYLITIS, ANKYLOSING;

EID: 84927067945     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445307     Document Type: Article

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