Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 1506-1514

  Zhang, Weipeng ^a   Cai, Jiangxia ^a,b   Chen, Siying ^a   Zheng, Xiaowei ^a   Hu, Sasa ^a   Dong, Weihua ^a   Lu, Jun ^a   Xing, Jianfeng ^a   Dong, Yalin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Department of Pharmacy   (China)

Author keywords

Breast cancer; Paclitaxelresistance; Paeonol; Phosphatidylinositol 3 kinase Akt; SET

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PEONOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SET PROTEIN; UNCLASSIFIED DRUG; ACETOPHENONE DERIVATIVE; CHAPERONE; ONCOPROTEIN; SET PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER RESISTANCE; CELL VIABILITY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MCF 7 CELL LINE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BIOSYNTHESIS; BREAST NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; SIGNAL TRANSDUCTION;

ACETOPHENONES; APOPTOSIS; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE CHAPERONES; HUMANS; MCF-7 CELLS; ONCOGENE PROTEIN V-AKT; PACLITAXEL; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84926673931     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3468     Document Type: Article

References (43)

1. Bhoo-Pathy N, Yip CH, Hartman M, et al Breast cancer research in Asia adopt or adapt Western knowledge? Eur J Cancer 49 703-709, 2013.
2. Kim H, Park GS, Lee JE and Kim JH A leukotriene B4 receptor-2 is associated with paclitaxel resistance in MCF-7/DOX breast cancer cells. Br J Cancer 109 351-359, 2013.
3. Ajabnoor GM, Crook T and Coley HM Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis 3 e260, 2012.
4. Carrara L, Guzzo F, Roque DM, et al Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. Gynecol Oncol 125 231-236, 2012.
5. Yin S, Zeng C, Hari M and Cabral F Random mutagenesis of beta-tubulin defines a set of dispersed mutations that confer paclitaxel resistance. Pharm Res 29 2994-3006, 2012.
6. Zhang J, Zhao J, Zhang W, et al Establishment of paclitaxel-resistant cell line and the underlying mechanism on drug resistance. Int J Gynecol Cancer 22 1450-1456, 2012.
7. Bhattacharya R and Cabral F Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance. J Biol Chem 284 13023-13032, 2009.
8. Miller AV, Hicks MA, Nakajima W, Richardson AC, Windle JJ and Harada H Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor. PLoS One 8 e60685, 2013.
9. Youns M, Hoheisel JD and Efferth T Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours. Curr Drug Discov Technol 7 37-45, 2010.
10. Lee H, Lee G, Kim H and Bae H Paeonol, a major compound of moutan cortex, attenuates Cisplatin-induced nephrotoxicity in mice. Evid Based Complement Alternat Med 2013 310989, 2013.
11. Huang H, Chang EJ, Lee Y, Kim JS, Kang SS and Kim HH A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages. Inflamm Res 57 189-198, 2008.
12. Lee B, Shin YW, Bae EA, et al Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch Pharm Res 31 445-450, 2008.
13. Ishiguro K, Ando T, Maeda O, et al Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Toxicol Appl Pharmacol 217 35-42, 2006.
14. Zhou J, Zhou L, Hou D, Tang J, Sun J and Bondy SC Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease. Brain Res 1388 141-147, 2011.
15. Xu SP, Sun GP, Shen YX, Peng WR, Wang H and Wei W Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines. Acta Pharmacol Sin 28 869-878, 2007.
16. Kim SA, Lee HJ, Ahn KS, et al Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biol Pharm Bull 32 1142-1147, 2009.
17. Fan L, Song B, Sun G, Ma T, Zhong F and Wei W Endoplasmic reticulum stress-induced resistance to Doxorubicin is reversed by paeonol treatment in human hepatocellular carcinoma cells. PLoS One 8 e62627, 2013.
18. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A and Grosveld G Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes characterization of the set gene. Mol Cell Biol 12 3346-3355, 1992.
19. Canela N, Rodriguez-Vilarrupla A, Estanyol JM, et al The SET protein regulates G2/M transition by modulating cyclin B-cyclin-dependent kinase 1 activity. J Biol Chem 278 1158-1164, 2003.
20. Zhang P, Compagnone NA, Fiore C, et al Developmental gonadal expression of the transcription factor SET and its target gene, P450c17 (17alpha-hydroxylase/c17,20 lyase). DNA Cell Biol 20 613-624, 2001.
21. Wagner S, Weber S, Kleinschmidt MA, Nagata K and Bauer UM SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. J Biol Chem 281 27242-27250, 2006.
22. Madeira A, Pommet JM, Prochiantz A and Allinquant B SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. Faseb J 19 1905-1907, 2005.
23. Almeida LO, Goto RN, Pestana CR, et al SET overexpression decreases cell detoxification efficiency ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. FEBS J 279 4615-4628, 2012.
24. Boqun X, Xiaonan D, Yugui C, et al Expression of SET protein in the ovaries of patients with polycystic ovary syndrome. Int J Endocrinol 2013 367956, 2013.
25. Cervoni N, Detich N, Seo SB, Chakravarti D and Szyf M The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. J Biol Chem 277 25026-25031, 2002.
26. Switzer CH, Cheng RY, Vitek TM, Christensen DJ, Wink DA and Vitek MP Targeting SET/I (2) PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. Oncogene 30 2504-2513, 2011.
27. Chen S, Dong Q, Hu S, et al Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells. Mol Biosyst 10 294-303, 2014.
28. Chen LM, Liang YJ and Ruan JW, et al Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318. J Pharm Pharmacol 56 1061-1066, 2004.
29. Liu XD, Sun H and Liu GT 5-Bromotetrandrine enhances the sensitivity of doxorubicin-induced apoptosis in intrinsic resistant human hepatic cancer Bel7402 cells. Cancer Lett 292 24-31, 2010.
30. Fazly BB, Iranshahi M, Naderinasab M, Hajian S, Sabeti Z and Masumi E Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus. Res Pharm Sci 5 21-28, 2010.
31. Cai J, Chen S and Zhang W, et al Salvianolic acid A reverses paclitaxel resistance in human breast cancer MCF-7 cells via targeting the expression of transgelin 2 and attenuating PI3 K/Akt pathway. Phytomedicine 21 1725-1732, 2014.
32. Chen SY, Hu SS, Dong Q, et al Establishment of paclitaxel-resistant breast cancer cell line and nude mice models and underlying multidrug resistance mechanisms in vitro and in vivo. Asian Pac J Cancer Prev 14 6135-6140, 2013.
33. Nakanishi T and Ross DD Breast cancer resistance protein (BCRP/ABCG2) its role in multidrug resistance and regulation of its gene expression. Chin J Cancer 31 73-99, 2012.
34. Li Z, Tian T, Hu X, et al Six1 mediates resistance to paclitaxel in breast cancer cells. Biochem Biophys Res Commun 441 538-543, 2013.
35. Leopoldino AM, Squarize CH, Garcia CB, et al SET protein accumulates in HNSCC and contributes to cell survival antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol 48 1106-1113, 2012.
36. Rooswinkel RW, van de Kooij B, de Vries E, et al Anti-apoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity. Blood 123 2806-2815, 2014.
37. Mao Z, Zhou J, Luan J, Sheng W, Shen X and Dong X Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells. Biomed Pharmacother 68 179-183, 2014.
38. Kazi AA, Gilani RA, Schech AJ, et al Nonhypoxic regu-lation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res 16 R15, 2014.
39. Cheng L, Luo S, Jin C, Ma H, Zhou H and Jia L FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway. Cell Death Dis 4 e923, 2013.
40. Pick A and Wiese M Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway. Chem Med Chem 7 650-662, 2012.
41. Yin J, Wu N, Zeng F, Cheng C, Kang K and Yang H Paeonol induces apoptosis in human ovarian cancer cells. Acta Histochem 115 835-839, 2013.
42. Bao MH, Zhang YW and Zhou HH Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-kappaB pathway. J Ethnopharmacol 146 543-551, 2013.
43. Ponnurangam S, Standing D, Rangarajan P and Subramaniam D Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. Mol Cancer Ther 12 598-609, 2013.