Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease

Brain Research

Volumn 1388, Issue , 2011, Pages 141-147

  Zhou, Jun ^a   Zhou, Li ^a   Hou, Deren ^a   Tang, Jiaochun ^a   Sun, Juanjuan ^a   Bondy, Stephen C ^b  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid; Actin; Alzheimer's disease; Cytochrome oxidase; Paeonol

Indexed keywords

ALPHA ACTIN; AMYLOID BETA PROTEIN; CYTOCHROME C OXIDASE; PEONOL; SODIUM CHLORIDE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR; BIOCHEMISTRY; BRAIN; BRAIN BLOOD VESSEL; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SHAM PROCEDURE;

ACETOPHENONES; ACTINS; ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; ELECTRON TRANSPORT COMPLEX IV; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MUSCLE, SMOOTH, VASCULAR; PAEONIA; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; PAEONIA SUFFRUTICOSA; RATTUS;

EID: 79954724910     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.02.064     Document Type: Article

References (27)

1. J.P. Blass, G.E. Gibson, and S. Hoyer The role of the metabolic lesion in Alzheimer's disease J. Alz. Dis. 4 2002 225 232 (Pubitemid 35006054)
2. H.S. Chae, O.H. Kang, Y.S. Lee, J.G. Choi, Y.C. Oh, H.J. Jang, M.S. Kim, J.H. Kim, S.I. Jeong, and D.Y. Kwon Inhibition of LPS-induced iNOS, COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264.7 cells Am. J. Chin. Med. 37 2009 181 194
3. T.E. Golde The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease Brain Pathol. 15 2005 84 87 (Pubitemid 40224071)
4. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356 (Pubitemid 34790756)
5. C.L. Hsieh, C.Y. Cheng, T.H. Tsai, I.H. Lin, C.H. Liu, S.Y. Chiang, J.G. Lin, C.J. Lao, and N.Y. Tang Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats J. Ethnopharmacol. 106 2006 208 215
6. X. Huang, C.S. Atwood, M.A. Hartshorn, G. Multhaup, L.E. Goldstein, R.C. Scarpa, M.P. Cuajungco, D.N. Gray, J. Lim, R.D. Moir, R.E. Tanzi, and A.I. Bush The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry 38 1999 7609 7616 (Pubitemid 29289332)
7. S.A. Kim, H.J. Lee, K.S. Ahn, H.J. Lee, E.O. Lee, K.S. Ahn, S.H. Choi, S.J. Jung, J.Y. Kim, N. Baek, and S.H. Kim Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases Biol. Pharm. Bull. 32 2009 1142 1147
8. S.H. Kim, S.A. Kim, M.K. Park, S.H. Kim, Y.D. Park, H.J. Na, H.M. Kim, M.K. Shin, and K.S. Ahn Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha Int. Immunopharmacol. 4 2004 279 287 (Pubitemid 38296356)
9. Y.J. Li, J.X. Bao, J.W. Xu, F. Murad, and K. Bian Vascular dilation by paeonol-a mechanism study Vasc. Pharmacol. 53 2010 169 176
10. M.T. Lin, and M.F. Beal Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 443 2006 787 795 (Pubitemid 44622683)
11. H. Matsuda, T. Ohta, A. Kawaguchi, and M. Yoshikawa Bioactive constituents of Chinese natural medicines. VI. Moutan cortex. (2): structures and radical scavenging effects of suffruticosides A, B, C, D, and E and galloyl-oxypaeoniflorin Chem. Pharm. Bull. (Tokyo) 49 2001 69 72 (Pubitemid 32128097)
12. A.A. Miller, K. Budzyn, and C.G. Sobey Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention Clin. Sci. (Lond.) 119 2010 1 17
13. J.C. Morris, M. Storandt, J.P. Miller, D.W. McKeel, J.L. Price, E.H. Rubin, and L. Berg Mild cognitive impairment represents early-stage Alzheimer disease Arch. Neurol. 5 2001 397 405 (Pubitemid 32217456)
14. I.T. Nizamutdinova, H.M. Oh, Y.N. Min, S.H. Park, M.J. Lee, J.S. Kim, M.H. Yean, S.S. Kang, Y.S. Kim, K.C. Chang, and H.J. Kim Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways Int. Immunopharmacol. 7 2007 343 350 (Pubitemid 46186173)
15. D. Paris, K. Townsend, A. Quadros, J. Humphrey, J. Sun, S. Brem, M. Wotoczek-Obadia, A. DelleDonne, N. Patel, D.F. Obregon, R. Crescentini, L. Abdullah, D. Coppola, A.M. Rojiani, F. Crawford, S.M. Sebti, and M. Mullan Inhibition of angiogenesis by Abeta peptides Angiogenesis 7 2004 75 85
16. G. Perry, R.J. Castellani, K. Hirai, and M.A. Smith Reactive oxygen species mediate cellular damage in Alzheimer disease J. Alz. Dis. 1 1998 45 55
17. C.J. Pike, N. Ramezan Arab, and C.W. Cotman β Amyloid neurotoxicity in: vitro evidence of oxidative stress but not protection by antioxidants J. Neurochem. 69 1997 1601 1609
18. P.S. Ravindra, S. Pratap, S. Shashwat, and K. Suman Free radicals and oxidative stress in neurodegenerative diseases: relevance of dietary antioxidants J. Ind. Acad. Clin. Med. 5 2004 218 225
19. Q. Shi, and G.E. Gibson Oxidative stress and transcriptional regulation in Alzheimer disease Alz. Dis. Assoc. Disord. 21 2007 276 291 (Pubitemid 350307432)
20. M.E. Witte, J.J. Geurts, H.E. de Vries, P. van der Valk, and J. van Horssen Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration? Mitochondrion 10 2010 411 418
21. J.B. Wu, N.N. Song, X.B. Wei, H.S. Guan, and X.M. Zhang Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury J. Neurol. Sci. 264 2008 50 55
22. D. Xu, C. Zhou, and B. Xu Protective effect of paeonol on beta-amyloid 25-35 induced toxicity in PC12 cells Neural Regen. Res. 3 2008 863 866
23. L. Ye, and J.T. Qiao Suppressive action produced by beta-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-d-aspartate receptor-independent: it's offset by huperzine Neurosci. Lett. 275 1999 187 190 (Pubitemid 29507538)
24. J. Yuan, and B.A. Yankner Apoptosis in the nervous system Nature 407 2000 802 809
25. H.Y. Zhang, C.Y. Zheng, H. Yan, Z.F. Wang, L.L. Tang, X. Gao, and X.C. Tang Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia Chem. Biol. Interact. 175 2008 396 402
26. J.M. Zhang, M.N. Wu, J.S. Qi, and J.T. Qiao Amyloid beta-protein fragment 31-35 suppresses long-term potentiation in hippocampal CA1 region of rats in vivo Synapse 60 2006 307 313
27. S.Z. Zhong, Q.H. Ge, R. Qu, Q. Li, and S.P. Ma Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice J. Neurol. Sci. 277 2009 58 64