SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates

FEBS Journal

Volumn 279, Issue 24, 2012, Pages 4615-4628

  Almeida, Luciana O ^a   Goto, Renata N ^a   Pestana, Cezar R ^a   Uyemura, Sérgio A ^a   Gutkind, Silvio ^b   Curti, Carlos ^a   Leopoldino, Andréia M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

ALDH2; BRCA2; cisplatin; ethanol; GSTP1

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CISPLATIN; COMPLEMENTARY DNA; DNA; GLUTATHIONE TRANSFERASE P1; MESSENGER RNA; PROTEIN P53; PROTEIN SET; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ALDH2 GENE; ARTICLE; ATM GENE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DETOXIFICATION; CELL FUNCTION; CELL STRAIN HEK293; CELL VIABILITY; CHEK2 GENE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; GENE CONTROL; GSTP1 GENE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TP53 GENE; TUMOR SUPPRESSOR GENE; UPREGULATION;

ALDEHYDE DEHYDROGENASE; CELL LINE; DNA DAMAGE; DOWN-REGULATION; GLUTATHIONE S-TRANSFERASE PI; HISTONE CHAPERONES; HUMANS; TRANSCRIPTION FACTORS;

NICOTIANA TABACUM;

EID: 84870520825     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12047     Document Type: Article

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