The effects of aerobic exercise training on serum osteocalcin, adipocytokines and insulin resistance on obese young males

Clinical Endocrinology

Volumn 82, Issue 5, 2015, Pages 686-694

  Kim, Yu Sik ^a   Nam, Ji Sun ^a   Yeo, Dong Wook ^b   Kim, Kyung Rae ^a   Suh, Sang Hoon ^c   Ahn, Chul Woo ^a  

^a Yonsei University College of Medicine   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; LEPTIN; OSTEOCALCIN; ADIPOCYTOKINE;

ADULT; AEROBIC EXERCISE; ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; BODY FAT; BODY WEIGHT; BONE DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; EXERCISE; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; METABOLIC PARAMETERS; OBESITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; WAIST CIRCUMFERENCE; YOUNG ADULT; BLOOD; BODY MASS; CROSS-SECTIONAL STUDY; ENERGY METABOLISM;

ADIPOKINES; ADIPOSITY; ADULT; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; ENERGY METABOLISM; EXERCISE; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; OBESITY; OSTEOCALCIN; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84926639796     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12601     Document Type: Article

References (33)

1. Takeda, S., Elefteriou, F., Levasseur, R., et al,. (2002) Leptin regulates bone formation via the sympathetic nervous system. Cell, 111, 305-317.
2. Elefteriou, F., Takeda, S., Ebihara, K., et al,. (2004) Serum leptin level is a regulator of bone mass. Proceedings of the National Academy of Sciences of the United States of America, 101, 3258-3263.
3. Elefteriou, F., Ahn, J.D., Takeda, S., et al,. (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature, 434, 514-520.
4. Singh, M.K., Elefteriou, F., &, Karsenty, G., (2008) Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule. Endocrinology, 149, 3933-3941.
5. Lee, N.K., Sowa, H., Hinoi, E., et al,. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell, 130, 456-469.
6. Maillard, C., Berruyer, M., Serre, C.M., et al,. (1992) Protein-S, A vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts. Endocrinology, 130, 1599-1604.
7. Kim, Y.S., Paik, I.Y., Rhie, Y.J., et al,. (2010) Integrative physiology: defined novel metabolic roles of osteocalcin. Journal of Korean Medical Science, 25, 985-991.
8. Motyl, K.J., McCabe, L.R., &, Schwartz, A.V., (2010) Bone and glucose metabolism: a two-way street. Archives of Biochemistry and Biophysics, 503, 2-10.
9. Ducy, P., (2011) The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia, 54, 1291-1297.
10. Im, J.A., Yu, B.P., Jeon, J.Y., et al,. (2008) Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clinica Chimica Acta, 396, 66-69.
11. Kindblom, J.M., Ohlsson, C., Ljunggren, O., et al,. (2008) Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. Journal of Bone and Mineral Research, 24, 785-791.
12. Kanazawa, I., Yamaguchi, T., Yamamoto, M., et al,. (2009) Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 94, 45-49.
13. Shea, M.K., Gundberg, C.M., Meigs, J.B., et al,. (2009) Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. American Journal of Clinical Nutrition, 90, 1230-1235.
14. Ronti, T., Lupattelli, G., &, Mannarino, E., (2006) The endocrine function of adipose tissue: an update. Clinical Endocrinology (Oxford), 64, 355-365.
15. Pittas, A.G., Harris, S.S., Eliades, M., et al,. (2009) Association between serum osteocalcin and markers of metabolic phenotype. Journal of Clinical Endocrinology and Metabolism, 94, 827-832.
16. Yoshizawa, T., Hinoi, E., Jung, D.Y., et al,. (2009) The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. The Journal of Clinical Investigation, 119, 2807-2817.
17. Yadav, V.K., Oury, F., Suda, N., et al,. (2009) A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell, 138, 976-989.
18. Gravenstein, K.S., Napora, J.K., Short, R.G., et al,. (2011) Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism. Journal of Clinical Endocrinology and Metabolism, 96, E884-E890.
19. Villareal, D.T., Fontana, L., Weiss, E.P., et al,. (2006) Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Archives of Internal Medicine, 166, 2502-2510.
20. Levinger, I., Zebaze, R., Jerums, G., et al,. (2011) The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporosis International, 22, 1621-1626.
21. Fernández-Real, J.M., Izquierdo, M., Ortega, F., et al,. (2009) The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. Journal of Clinical Endocrinology and Metabolism, 94, 237-245.
22. Lee, A.J., Hodges, S., &, Eastell, R., (2000) Measurement of osteocalcin. Annals of Clinical Biochemistry, 37, 432-436.
23. Mizuguchi, M., Fujisawa, R., Nara, M., et al,. (2001) Fourier-Transform Infrared Spectroscopic Study of Ca2 + -Binding to Osteocalcin. Calcified Tissue International, 69, 337-342.
24. Gower, B.A., Pollack, N.K., Casazza, K., et al,. (2013) Associations of total and undercarboxylated osteocalcin with peripheral and hepatic insulin sensitivity and b-cell function in overweight adults. Journal of Clinical Endocrinology and Metabolism, 98, E1173-E1180.
25. Rached, M.T., Kode, A., Silva, B.C., et al,. (2010) FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. The Journal of Clinical Investigation, 120, 357-368.
26. Menuki, K., Mori, T., Sakai, A., et al,. (2008) Climbing exercise enhances osteoblast differentiation and inhibits adipogenic differentiation with high expression of PTH/PTHrP receptor in bone marrow cells. Bone, 43, 613-620.
27. Ahdjoudj, S., Fromigue, O., &, Marie, P.J., (2004) Plasticity and regulation of human bone marrow stromal osteoprogenitor cells: potential implication in the treatment of age-related bone loss. Histology and Histopathology, 19, 151-157.
28. Chen, Y.J., Huang, C.H., Lee, I.C., et al,. (2008) Effects of cyclic mechanical stretching on the mRNA expression of tendon/ligament-related and osteoblast-specific genes in human mesenchymal stem cells. Connective Tissue Research, 49, 7-14.
29. Bortell, R., Owen, T.A., Bidwell, J.P., et al,. (1992) Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proceedings of the National Academy of Sciences of the United States of America, 89 (), 6119-6123.
30. Gill, J.M., &, Malkova, D., (2006) Physical activity, fitness and cardiovascular disease risk in adults: interactions with insulin resistance and obesity. Clinical Science (London), 110, 409-425.
31. Holloszy, J.O., (2005) Exercise-induced increase in muscle insulin sensitivity. Journal of Applied Physiology, 99, 338-343.
32. Yeap, B.B., Chubb, S.A., Flicker, L., et al,. (2010) Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. European Journal of Endocrinology, 163, 265-272.
33. Kanazawa, I., Yamaguchi, T., Yamauchi, M., et al,. (2011) Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporosis International, 22, 187-194.