Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule

Endocrinology

Volumn 149, Issue 8, 2008, Pages 3933-3941

  Singh, Manvendra K ^a   Elefteriou, Florent ^b   Karsenty, Gerard ^a,c  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c Howard Hughes Medical Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; COCAINE; LEPTIN; NEUROPEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; BONE MASS; BONE REMODELING; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT; HORMONAL REGULATION; HYPOPHYSIS; MEDIATOR; MOLECULE; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOCLAST; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BONE DENSITY; BONE REMODELING; CELLS, CULTURED; GREEN FLUORESCENT PROTEINS; INJECTIONS, INTRAVENTRICULAR; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEUROPEPTIDES; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER;

EID: 47949114080     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0109     Document Type: Article

References (39)

1. Karsenty G 2006 Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 4:341-348
2. Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M 2006 FSH directly regulates bone mass. Cell 21:125:247-260
3. Sun L, Davies TF, Blair HC, Abe E, Zaidi M 2006 TSH and bone loss. Ann NY Acad Sci 1068:309-318
4. Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M 2003 TSH is a negative regulator of skeletal remodeling. Cell 17:115:151-162
5. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G 2000 Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100: 197-207
6. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G 2002 Leptin regulates bone formation via the sympathetic nervous system. Cell 111:305-317
7. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G 2005 Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514-520
8. Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G 2005 The molecular clock mediates leptin-regulated bone formation. Cell 122:803-815
9. Ahn JD, Dubern B, Lubrano-Berthelier C, Clement K, Karsenty G 2006 Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4-receptor deficiency. Endocrinology 147:3196-3202
10. Baldock PA, Sainsbury A, Couzens M, Enriquez RF, Thomas GP, Gardiner EM, Herzog H 2002 Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 109:915-921
11. Koylu EO, Couceyro PR, Lambert PD, Ling NC, DeSouza EB, Kuhar MJ 1997 Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 9:823-833
12. Wierup N, Sundler F 2006 CART is a novel islet regulatory peptide. Peptides 27:2031-2036
13. Douglass J, McKinzie AA, Couceyro P 1995 PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 2471-2481
14. Douglass J, Daoud S 1996 Characterization of the human cDNA and genomic DNAencoding CART: a cocaine- and amphetamine-regulated transcript. Gene 169:241-245
15. Vrang N, Larsen PJ, Kristensen P 2002 Cocaine-amphetamine regulated transcript (CART) expression is not regulated by amphetamine. Neuroreport 13: 1215-1218
16. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S 1998 Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76
17. Qing K, Chen Y 2007 Central CART gene delivery by recombinant AAV vector attenuates body weight gain in diet-induced-obese rats. Regul Pept 140:21-26
18. Adams LD, Gong W, Vechia SD, Hunter RG, Kuhar MJ 1999 CART: from gene to function. Brain Res 848:137-140
19. Dacquin R, Starbuck M, Schinke T, Karsenty G 2002 Mouse α1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev Dyn 224:245-251
20. Chappard D, Palle S, Alexandre C, Vico L, Riffat G 1987 Bone embedding in pure methyl methacrylate at low temperature preserves enzyme activities. Acta Histochem 81:183-190
21. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610
22. Parfitt AM 1988 Bone histomorphometry: standardization of nomenclature, symbols and units. Summary of proposed system. Bone Miner 4:1-5
23. Suda T, Jimi E, Nakamura I, Takahashi N 1997 Role of 1α, 25-dihydroxyvitamin D3 in osteoclast differentiation and function. Methods Enzymol 282: 223-235
24. Baron RVA, Neff L, Silverglate A, Maria AS 1983 Processing of undecalcified bone specimens for bone histomorphometry. Boca Raton, FL: CRC Press
25. Ducy P, Starbuck M, Priemel M, Shen J, Pinero G, Geoffroy V, Amling M, Karsenty G 1999 A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 13:1025-1036
26. Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G 2004 Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA 101:3258-3263
27. Eyre DR, Dickson IR, Van Ness K 1988 Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues. Biochem J 252:495-500
28. Choi YH, Della-Fera MA, Li C, Hartzell DL, Little DE, Kuhar MJ, Baile CA 2004 CART peptide: central mediator of leptin-induced adipose tissue apoptosis? Regul Pept 121:155-162
29. Muzzin P, Cusin I, Charnay Y, Rohner-Jeanrenaud F 2000 Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats. Regul Pept 92:57- 64
30. Bagnasco M, Dube MG, Kalra PS, Kalra SP 2002 Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 143:4409-4421
31. Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP 2002 Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Diabetes 51:1729-1736
32. Kalra PS, Kalra SP 2002 Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy. Drugs Today (Barc) 38:745-757
33. Gardiner JV, Kong WM, Ward H, Murphy KG, Dhillo WS, Bloom SR 2005 AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem Biophys Res Commun 327:1088-1093
34. Mori K, Gehlbach P, Yamamoto S, Duh E, Zack DJ, Li Q, Berns KI, Raisler BJ, Hauswirth WW, Campochiaro PA 1994 AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 43:1994-2000
35. Prasad KM, Yang Z, Bleich D, Nadler JL 2000 Adeno-associated virus vector mediated gene transfer to pancreatic β cells. Gene Ther 7:1553-1561
36. Sato S, Hanada R, Kimura A, Abe T, Matsumoto T, Iwasaki M, Inose H, Ida T, Mieda M, Takeuchi Y, Fukumoto S, Fujita T, Kato S, Kangawa K, Kojima M, Shinomiya K, Takeda S 2007 Central control of bone remodeling by neuromedin U. Nat Med 13:1234-1240
37. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua Jr S, Elmquist JK, Lowell BB 2006 Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal bodyweight homeostasis. Neuron 49:191-203
38. Wierup N, Richards WG, Bannon AW, Kuhar MJ, Ahrén B, Sundler F 2005 CART knock out mice have impaired insulin secretion and glucose intolerance, altered β cell morphology and increased body weight. Regul Pept 129:203-211
39. Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen YF, Hsiung HM, Köster A 2001 Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology 142:4394-4400