Anterior thalamic paraventricular nucleus is involved in intermittent access ethanol drinking: Role of orexin receptor 2

Addiction Biology

Volumn 20, Issue 3, 2015, Pages 469-481

  Barson, Jessica R ^a   Ho, Hui Tin ^a   Leibowitz, Sarah F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

c Fos; emotional behavior; immunohistochemistry; intermittent access; microinjection; rat

Indexed keywords

ALCOHOL; MESSENGER RNA; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; 1-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)-3,3-DIMETHYL-2-((4-PYRIDINYLMETHYL)AMINO)-1-BUTANONE; CENTRAL DEPRESSANT AGENT; ISOQUINOLINE DERIVATIVE; OREXIN RECEPTOR; OREXIN RECEPTOR ANTAGONIST; PROTEIN C FOS; PYRIDINE DERIVATIVE; SUCROSE; SWEETENING AGENT;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; EMOTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTERMITTENT ACCESS ETHANOL DRINKING; MALE; MICROINJECTION; NONHUMAN; ONCOGENE C FOS; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; RAT; ADAPTIVE BEHAVIOR; ANIMAL; DRUG EFFECTS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; LONG EVANS RAT; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVENTION AND CONTROL; REINFORCEMENT; UPREGULATION;

ALCOHOL DRINKING; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEEDBACK, PSYCHOLOGICAL; HYPOTHALAMUS; ISOQUINOLINES; MALE; NEURONS; OREXIN RECEPTOR ANTAGONISTS; OREXIN RECEPTORS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDINES; RATS, LONG-EVANS; REINFORCEMENT SCHEDULE; SUCROSE; SWEETENING AGENTS; UP-REGULATION;

EID: 84926521757     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12139     Document Type: Article

References (38)

1. Bell RL, Rodd ZA, Lumeng L, Murphy JM, McBride WJ, (2006) The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol 11: 270-288.
2. Brown RM, Khoo SY, Lawrence AJ, (2013) Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats. Int J Neuropsychopharmacol 16: 2067-2079.
3. Choi DL, Davis JF, Magrisso IJ, Fitzgerald ME, Lipton JW, Benoit SC, (2012) Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat. Neuroscience 210: 243-248.
4. Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M, (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A 96: 748-753.
5. Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F, (2008) Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 63: 152-157.
6. Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE, (2011) A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience 196: 80-96.
7. Hamlin AS, Clemens KJ, Choi EA, McNally GP, (2009) Paraventricular thalamus mediates context-induced reinstatement (renewal) of extinguished reward seeking. Eur J Neurosci 29: 802-812.
8. Heydendael W, Sharma K, Iyer V, Luz S, Piel D, Beck S, Bhatnagar S, (2011) Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress. Endocrinology 152: 4738-4752.
9. Hirose M, Egashira S, Goto Y, Hashihayata T, Ohtake N, Iwaasa H, Hata M, Fukami T, Kanatani A, Yamada K, (2003) N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett 13: 4497-4499.
10. Kim AK, Brown RM, Lawrence AJ, (2012) The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship. Front Behav Neurosci 6: 78.
11. Kirouac GJ, Parsons MP, Li S, (2005) Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus. Brain Res 1059: 179-188.
12. Kolaj M, Doroshenko P, Yan Cao X, Coderre E, Renaud LP, (2007) Orexin-induced modulation of state-dependent intrinsic properties in thalamic paraventricular nucleus neurons attenuates action potential patterning and frequency. Neuroscience 147: 1066-1075.
13. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B, (2006) The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148: 752-759.
14. Li J, Bian W, Dave V, Ye JH, (2011a) Blockade of GABA(A) receptors in the paraventricular nucleus of the hypothalamus attenuates voluntary ethanol intake and activates the hypothalamic-pituitary-adrenocortical axis. Addict Biol 16: 600-614.
15. Li S, Kirouac GJ, (2008) Projections from the paraventricular nucleus of the thalamus to the forebrain, with special emphasis on the extended amygdala. J Comp Neurol 506: 263-287.
16. Li Y, Li S, Sui N, Kirouac GJ, (2009) Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats. Pharmacol Biochem Behav 93: 506-514.
17. Li Y, Wang H, Qi K, Chen X, Li S, Sui N, Kirouac GJ, (2011b) Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal. Physiol Behav 102: 42-50.
18. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK, (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435: 6-25.
19. Martin-Fardon R, Boutrel B, (2012) Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry? Front Behav Neurosci 6: 75.
20. Morganstern I, Chang GQ, Barson JR, Ye Z, Karatayev O, Leibowitz SF, (2010) Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus. Alcohol Clin Exp Res 34: 886-896.
21. Mould R, Brown J, Marshall FH, Langmead CJ, (2014) Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol 171: 351-363.
22. Paivarinta P, Korpi ER, (1993) Voluntary ethanol drinking increases locomotor activity in alcohol-preferring AA rats. Pharmacol Biochem Behav 44: 127-132.
23. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS, (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996-10015.
24. Quertemont E, Green HL, Grant KA, (2003) Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and time. Psychopharmacology (Berl) 168: 262-270.
25. Ryabinin AE, Wang YM, (1998) Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Alcohol Clin Exp Res 22: 1646-1654.
26. Ryabinin AE, Criado JR, Henriksen SJ, Bloom FE, Wilson MC, (1997) Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol. Mol Psychiatry 2: 32-43.
27. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M, (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585.
28. Salazar-Juarez A, Escobar C, Aguilar-Roblero R, (2002) Anterior paraventricular thalamus modulates light-induced phase shifts in circadian rhythmicity in rats. Am J Physiol Regul Integr Comp Physiol 283: R897-R904.
29. Schneider ER, Rada P, Darby RD, Leibowitz SF, Hoebel BG, (2007) Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 31: 1858-1865.
30. Sharko AC, Kaigler KF, Fadel JR, Wilson MA, (2013) Individual differences in voluntary ethanol consumption lead to differential activation of the central amygdala in rats: relationship to the anxiolytic and stimulant effects of low dose ethanol. Alcohol Clin Exp Res 37 (Suppl. 1): E172-E180.
31. Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R, Bartlett SE, (2008) Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 32: 1816-1823.
32. Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA, Jerman JC, (2001) SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132: 1179-1182.
33. Timofeeva E, Richard D, (2001) Activation of the central nervous system in obese Zucker rats during food deprivation. J Comp Neurol 441: 71-89.
34. Vertes RP, Hoover WB, (2008) Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat. J Comp Neurol 508: 212-237.
35. Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M, (2009) Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 33: 945-969.
36. Wise RA, (1973) Voluntary ethanol intake in rats following exposure to ethanol on various schedules. Psychopharmacologia 29: 203-210.
37. Zhang GC, Mao LM, Liu XY, Wang JQ, (2007) Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration. J Neurochem 103: 400-407.
38. Zhang L, Renaud LP, Kolaj M, (2009) Properties of a T-type Ca2+channel-activated slow after hyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons. J Neurophysiol 101: 2741-2750.