Individual Differences in Voluntary Ethanol Consumption Lead to Differential Activation of the Central Amygdala in Rats: Relationship to the Anxiolytic and Stimulant Effects of Low Dose Ethanol

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue SUPPL.1, 2013, Pages

  Sharko, Amanda C ^a   Kaigler, Kris F ^a   Fadel, Jim R ^a   Wilson, Marlene A ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; Central amygdala; Limited access; Locomotor behavior

Indexed keywords

ALCOHOL; PROTEIN FOS;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BASOLATERAL AMYGDALA; BRAIN DEPTH STIMULATION; BRAIN REGION; CELL COUNT; CENTRAL NUCLEUS (AMYGDALA); CONTROLLED STUDY; DRINKING BEHAVIOR; ELECTROENCEPHALOGRAM; IMMUNOREACTIVITY; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; STRIA TERMINALIS;

ALCOHOL DRINKING; AMYGDALA; ANIMALS; ANXIETY; DRUG ADMINISTRATION SCHEDULE; ETHANOL; INDIVIDUALITY; MALE; MAZE LEARNING; RATS; RATS, LONG-EVANS;

ANIMALIA; RATTUS;

EID: 84872492875     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01907.x     Document Type: Article

References (43)

1. Agabio R, Carai MA, Lobina C, Pani M, Reali R, Vacca G, Gessa GL, Colombo G (2001) Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats. Alcohol 23:123-126.
2. Albrechet-Souza L, Borelli KG, Brandao ML (2008) Activity of the medial prefrontal cortex and amygdala underlies one-trial tolerance of rats in the elevated plus-maze. J Neurosci Methods 169:109-118.
3. Bachtell RK, Wang YM, Freeman P, Risinger FO, Ryabinin AE (1999) Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors. Brain Res 847:157-165.
4. Badia-Elder NE, Stewart RB, Powrozek TA, Murphy JM, Li TK (2003) Effects of neuropeptide Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcohol Clin Exp Res 27:894-899.
5. Bertoglio LJ, Carobrez AP (2002) Anxiolytic effects of ethanol and phenobarbital are abolished in test-experienced rats submitted to the elevated plus maze. Pharmacol Biochem Behav 73:963-969.
6. Boerngen-Lacerda R, Souza-Formigoni ML (2000) Does the increase in locomotion induced by ethanol indicate its stimulant or anxiolytic properties? Pharmacol Biochem Behav 67:225-232.
7. Burghardt PR, Pasumarthi RK, Wilson MA, Fedel J (2006) Alterations in fear conditioning and amygdalar activation following chronic wheel running in rats. Pharmacol Biochem Behav 84:306-312.
8. Chang SL, Patel NA, Romero AA (1995) Activation and desensitization of Fos immunoreactivity in the rat brain following ethanol administration. Brain Res 679:89-98.
9. Colombo G, Agabio R, Lobina C, Reali R, Zocchi A, Fadda F, Gessa GL (1995) Sardinian alcohol-preferring rats: a genetic animal model of anxiety. Physiol Behav 57:1181-1185.
10. Conrod PJ, Pihl RO, Vassileva J (1998) Differential sensitivity to alcohol reinforcement in groups of men at risk for distinct alcoholism subtypes. Alcohol Clin Exp Res 22:585-597.
11. Curran T, Morgan JI (1995) Fos: an immediate-early transcription factor in neurons. J Neurobiol 26:403-412.
12. Demartini KS, Carey KB (2011) The role of anxiety sensitivity and drinking motives in predicting alcohol use: a critical review. Clin Psychol Rev 31:169-177.
13. Duncan GE, Knapp DJ, Breese GR (1996) Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety. Brain Res 713:79-91.
14. Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL, Kalant H, Koob GF, Li TK, Tabakoff B (1998) Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 22:998-1040.
15. Ghozland S, Chu K, Kieffer BL, Roberts AJ (2005) Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice. Neuropharmacology 49:493-501.
16. Henniger MS, Spanagel R, Wigger A, Landgraf R, Holter SM (2002) Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior. Neuropsychopharmacology 26:729-736.
17. Herring BE, Mayfield RD, Camp MC, Alcantara AA (2004) Ethanol-induced Fos immunoreactivity in the extended amygdala and hypothalamus of the rat brain: focus on cholinergic interneurons of the nucleus accumbens. Alcohol Clin Exp Res 28:588-597.
18. Hitzemann B, Hitzemann R (1997) Genetics ethanol and the Fos response: a comparison of the C57BL/6J and DBA/2J inbred mouse strains. Alcohol Clin Exp Res 21:1497-1507.
19. Kash TL, Matthews RT, Winder DG (2008) Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis. Neuropsychopharmacology 33:1379-1390.
20. Kliethermes CL (2005) Anxiety-like behaviors following chronic ethanol exposure. Neurosci Biobehav Rev 28:837-850.
21. Koob GF (2003) Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27:232-243.
22. Kushner MG, Abrams K, Borchardt C (2000) The relationship between anxiety disorders and alcohol use disorders: a review of major perspectives and findings. Clin Psychol Rev 20:149-171.
23. Kushner MG, Wall MM, Krueger RF, Sher KJ, Maurer E, Thuras P, Lee S (2011) Alcohol dependence is related to overall internalizing psychopathology load rather than to particular internalizing disorders: evidence from a national sample. Alcohol Clin Exp Res 36:325-331.
24. Lack AK, Ariwodola OJ, Chappell AM, Weiner JL, McCool BA (2008) Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala. Neuropharmacology 55:661-668.
25. Moller C, Wiklund L, Thorsell A, Hyytia P, Heilig M (1997) Decreased measures of experimental anxiety in rats bred for high alcohol preference. Alcohol Clin Exp Res 21:656-660.
26. Morales M, Criado JR, Sanna PP, Henriksen SJ, Bloom FE (1998) Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala. Brain Res 798:333-336.
27. Olive MF, Mehmert KK, Koenig HN, Camarini R, Kim JA, Nannini MA, Ou CJ, Hodge CW (2003) A role for corticotropin releasing factor (CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficient mice. Psychopharmacology 165:181-187.
28. Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coordinates. 2nd ed. Academic Press, Orlando, FL.
29. Primeaux SD, Wilson SP, Bray GA, York DA, Wilson MA (2006) Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" rats. Alcohol Clin Exp Res 30:791-801.
30. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005) Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav 84:53-63.
31. Roberto M, Madamba SG, Moore SD, Tallent MK, Siggins GR (2003) Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. Proc Natl Acad Sci U S A 100:2053-2058.
32. Silberman Y, Shi L, Brunso-Bechtold JK, Weiner JL (2008) Distinct mechanisms of ethanol potentiation of local and paracapsular GABAergic synapses in the rat basolateral amygdala. J Pharmacol Exp Ther 324:251-260.
33. Spanagel R, Montkowski A, Allingham K, Stohr T, Shoaib M, Holsboer F, Landgraf R (1995) Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. Psychopharmacology 122:369-373.
34. Stewart RB, Gatto GJ, Lumeng L, Li TK, Murphy JM (1993) Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 10:1-10.
35. Swendsen J, Conway KP, Degenhardt L, Glantz M, Jin R, Merikangas KR, Sampson N, Kessler RC (2010) Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey. Addiction 105:1117-1128.
36. Tambour S, Didone V, Tirelli E, Quertemont E (2005) Dissociation between the locomotor and anxiolytic effects of acetaldehyde in the elevated plus-maze: evidence that acetaldehyde is not involved in the anxiolytic effects of ethanol in mice. Eur Neuropsychopharmacol 15:655-662.
37. Thiele TE, van Dijk G, Bernstein IL (1997) Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption. Brain Res 756:278-282.
38. Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, Koob GF (2002) Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res 26:1494-1501.
39. Weitlauf C, Egli RE, Grueter BA, Winder DG (2004) High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalis. J Neurosci 24:5741-5747.
40. White LC, Ford KA, Fadel JR, Wilson MA (2009) Individual variation in anxiety and ethanol self-administration: a pheotypic analysis of limbic system neuronal activation. Presented at the International Behavioral Neuroscience Society Meeting, Nassau, Bahamas, June 9-14.
41. Wilson JH, Kelly SJ, Wilson MA (1996) Early postnatal alcohol exposure in rats: maternal behavior and estradiol levels. Physiol Behav 59:287-293.
42. Wilson MA, Burghardt PR, Ford KA, Wilkinson MB, Primeaux SD (2004) Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and females. Pharmacol Biochem Behav 78:445-458.
43. Zhang Z, Morse AC, Koob GF, Schulteis G (2007) Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcohol Clin Exp Res 31:1811-1819.