DNA copy number profiling reveals different patterns of chromosomal instability within colorectal cancer according to the age of onset

Molecular Carcinogenesis

Volumn 55, Issue 5, 2016, Pages 705-716

  Arriba, María ^a   García, Juan L ^b,c   Inglada Pérez, Lucía ^d,e   Rueda, Daniel ^a   Osorio, Irene ^a   Rodríguez, Yolanda ^a   Álvaro, Edurne ^f   Sánchez, Ricard ^a   Fernández, Tamara ^a   Pérez, Jessica ^b,c   Hernández, Jesús M ^b   Benítez, Javier ^d,e   González Sarmiento, Rogelio ^b,c   Urioste, Miguel ^d,e   Perea, José ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d Structural Biology and Biocomputing Programme   (Spain)

^e CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^f HOSPITAL UNIVERSITARIO INFANTA LEONOR   (Spain)

Author keywords

Array based comparative genomic hybridization; Early onset colorectal cancer; Late onset colorectal cancer

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; ANEUPLOIDY; ARTICLE; CHROMOSOMAL INSTABILITY; CHROMOSOME 1; CHROMOSOME 14P; CHROMOSOME 16P; CHROMOSOME 18; CHROMOSOME 19; CHROMOSOME 1P; CHROMOSOME 1Q; CHROMOSOME 7; CHROMOSOME 7Q; CHROMOSOME 9P; CHROMOSOME LOSS; COLORECTAL TUMOR; COMPARATIVE GENOMIC HYBRIDIZATION; GENE DOSAGE; GENOMIC INSTABILITY; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; VERY ELDERLY; COMPARATIVE STUDY; COPY NUMBER VARIATION; FEMALE; GENETICS; MALE; PATHOLOGY; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; COMPARATIVE GENOMIC HYBRIDIZATION; DNA COPY NUMBER VARIATIONS; FEMALE; HUMANS; MALE; YOUNG ADULT;

EID: 84926484859     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22315     Document Type: Article

References (30)

1. http://www.seom.org/seomcms/images/stories/recursos/sociosyprofs/documentacion/boletinseom/2010/66/09-reportaje-bol66.pdf.
2. Leslie A, Carey FA, Pratt NR, Steele RJ. The colorectal adenoma-carcinoma sequence. Br J Surg 2002; 89:845-860.
3. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643-649.
4. Perucho M. Cancer of the microsatellite mutator phenotype. Biol Chem 1996; 377:675-684.
5. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363:558-561.
6. Dunican DS, McWilliam P, Tighe O, Parle-McDermott A, Croke DT. Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization. Oncogene 2002; 21:3253-3257.
7. Goel A, Arnold CN, Niedzwiecki D, et al. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res 2003; 63:1608-1614.
8. Georgiades IB, Curtis LJ, Morris RM, Bird CC, Wyllie AH. Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence of chromosomal or microsatellite instability. Oncogene 1999; 18:7933-7940.
9. Tang R, Changchien CR, Wu M-C, et al. Colorectal cancer without high microsatellite instability and chromosomal instability: An alternative genetic pathway to human colorectal cancer. Carcinogenesis 2004; 25:841-846.
10. Banerjea A, Hands RE, Powar MP, Bustin SA, Dorudi S. Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence. Colorectal Dis 2009; 11:601-608.
11. Perea J, Rueda D, Canal A, et al. Age at onset should be a major criterion for subclassification of colorectal cancer. J Mol Diagn 2014; 16:116-126.
12. Perea J, Alvaro E, Rodríguez Y, et al. Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics. World J Gastroenterol 2010; 16:3697-3703.
13. Albertson DG, Collins C, McCormick F, Gray JW. Chromosome aberrations in solid tumors. Nat Genet 2003; 34:369-376.
14. Giráldez MD, López-Dóriga A, Bujanda L, et al. Susceptibility genetic variants associated with early-onset colorectal cancer. Carcinogenesis 2012; 33:613-619.
15. Berg M, Agesen TH, Thiis-Evensen E, et al. Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci. Mol Cancer 2010; 6:100.
16. Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005; 16:481-488.
17. Siegel RL, Jermal A, Ward EM. Increase in incidence of colorectal cancer among young men and women in the United States. Cancer Epidemiol Biomark Prev 2009; 18:1695-1698.
18. Carro A, Rico D, Rueda OM, Díaz-Uriarte R, Pisano DG. WaviCGH: A web application for the analysis and visualization of genomic copy number alterations. Nucleic Acids Res 2010; 38:W182-W187.
19. Bonnet F, Guedj M, Jones N, et al. An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis. BMC Med Genomics 2012; 5:54.
20. Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc B 1995; 57:289-300.
21. R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2012. ISBN 3-900051-07-0, URL http://www.R-project.org/
22. Chen Z, Liu Z, Li W, et al. Chromosomal copy number alterations are associated with tumor response to chemoradiation in locally advanced rectal cancer. Genes Chromosomes Cancer 2011; 50:689-699.
23. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487:330-337.
24. Ried T, Knutzen R, Steinbeck R, et al. Genes Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Chromosomes Cancer 1996; 15:234-245.
25. De Angelis PM, Clausen OP, Schjølberg A, Stokke T. Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. Br J Cancer 1999; 80:526-535.
26. Mourra N, Zeitoun G, Buecher B, et al. High frequency of chromosome 14 deletion in early-onset colon cancer. Dis Colon Rectum 2007; 50:1881-1886.
27. Ried T, Heselmeyer-Haddad K, Blegen H, Schröck E, Auer G. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: A phenotype/genotype correlation. Genes Chromosomes Cancer 1999; 25: 195-204.
28. Beroukhim R, Mermel CH, Porter D, et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010; 463:899-905.
29. Freyaldenhoven BS, Fried C, Wielckens K. FOXD4A and FOXD4B, two new winged helix transcription factors, are expressed in human leukemia cell lines. Gene 2002; 294:131-140.
30. Kim YJ, Jung YD, Kim TO, Kim HS. Alu-related transcript of TJP2 gene as a marker for colorectal cancer. Gene 2013; 524:268-274.