Physiological implications of biased signaling at histamine H2 receptors

Frontiers in Pharmacology

Volumn 6, Issue MAR, 2015, Pages

  Alonso, Natalia ^a,b   Zappia, Carlos D ^b,c   Cabrera, Maia ^b,c   Davio, Carlos A ^b,c,d   Shayo, Carina ^a,b   Monczor, Federico ^b,c   Fernández, Natalia C ^b,c  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b Universidad Nacional de Río Cuarto Consejo Nacional de Investigaciones Científicas y Técnicas   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d Instituto de Investigaciones Farmacologicas   (Argentina)

Author keywords

7TMR; Biased agonism; ERK; GPCR internalization; H2R ligands; HDC; Pluridimensional efficacy

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMTHAMINE; CYCLIC AMP; FAMOTIDINE; HISTAMINE; HISTAMINE H2 RECEPTOR; HISTIDINE DECARBOXYLASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; INTERNALIZATION; LONG TERM CARE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 84926482549     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00045     Document Type: Article

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