MKK3 mediates inflammatory response through modulation of mitochondrial function

Free Radical Biology and Medicine

Volumn 83, Issue , 2015, Pages 139-148

  Srivastava, Anup ^a   Shinn, Amanda S ^a   Lee, Patty J ^a   Mannam, Praveen ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute lung injury; Caspase 1; Free radicals; Inflammasome; Inflammation; Mitochondria; NF B; Oxidants; Sepsis

Indexed keywords

EOTAXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; CYTOKINE; LIPOPOLYSACCHARIDE; MAP2K3 PROTEIN, MOUSE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASAL METABOLIC RATE; BONE MARROW DERIVED MACROPHAGE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME ACTIVATION; INFLAMMATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

MUS;

ANIMALS; BLOTTING, WESTERN; BONE MARROW; CELLS, CULTURED; CYTOKINES; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE 3; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84926467771     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.01.035     Document Type: Article

References (39)

1. I. Lee, and M. Huttemann Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis Biochim. Biophys. Acta 1842 2014 1579 1586
2. M. Huttemann, S. Helling, T.H. Sanderson, C. Sinkler, L. Samavati, G. Mahapatra, A. Varughese, G. Lu, J. Liu, R. Ramzan, S. Vogt, L.I. Grossman, J.W. Doan, K. Marcus, and I. Lee Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation Biochim. Biophys. Acta 1817 2012 598 609
3. B. Debelec-Butuner, C. Alapinar, L. Varisli, B. Erbaykent-Tepedelen, S.M. Hamid, C. Gonen-Korkmaz, and K.S. Korkmaz Inflammation-mediated abrogation of androgen signaling: an in vitro model of prostate cell inflammation Mol. Carcinog. 53 2014 85 97
4. M.E. Andrades, C. Ritter, and F. Dal-Pizzol The role of free radicals in sepsis development Front. Biosci. 1 2009 277 287
5. M.J. Ryu, S.J. Kim, Y.K. Kim, M.J. Choi, S. Tadi, M.H. Lee, S.E. Lee, H.K. Chung, S.B. Jung, H.J. Kim, Y.S. Jo, K.S. Kim, S.H. Lee, J.M. Kim, G.R. Kweon, K.C. Park, J.U. Lee, Y.Y. Kong, C.H. Lee, J. Chung, and M. Shong Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice PLoS Genet. 9 2013 e1003356
6. J.C. Rodriguez-Prados, P.G. Traves, J. Cuenca, D. Rico, J. Aragones, P. Martin-Sanz, M. Cascante, and L. Bosca Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation J. Immunol. 185 2010 605 614
7. C.M. Krawczyk, T. Holowka, J. Sun, J. Blagih, E. Amiel, R.J. DeBerardinis, J.R. Cross, E. Jung, C.B. Thompson, R.G. Jones, and E.J. Pearce Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation Blood 115 2010 4742 4749
8. T. Inoue, D.L. Boyle, M. Corr, D. Hammaker, R.J. Davis, R.A. Flavell, and G.S. Firestein Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis Proc. Natl. Acad. Sci. USA 103 2006 5484 5489
9. D.H. Kim, and F.M. Ausubel Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans Curr. Opin. Immunol. 17 2005 4 10
10. P. Mannam, X. Zhang, P. Shan, Y. Zhang, A.S. Shinn, Y. Zhang, and P.J. Lee Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury J. Immunol. 190 2013 1264 1275
11. P. Mannam, A.S. Shinn, A. Srivastava, R.F. Neamu, W.E. Walker, M. Bohanon, J. Merkel, M.J. Kang, C.S. Dela Cruz, A.M. Ahasic, M.A. Pisani, M. Trentalange, A.P. West, G.S. Shadel, J.A. Elias, and P.J. Lee MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury Am. J. Physiol. Lung Cell. Mol. Physiol 306 2014 L604 L619
12. B.M. Emerling, L.C. Platanias, E. Black, A.R. Nebreda, R.J. Davis, and N.S. Chandel Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling Mol. Cell. Biol. 25 2005 4853 4862
13. Y. Emre, C. Hurtaud, T. Nubel, F. Criscuolo, D. Ricquier, and A.M. Cassard-Doulcier Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages Biochem. J. 402 2007 271 278
14. D. Brancho, N. Tanaka, A. Jaeschke, J.J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R.A. Flavell, and R.J. Davis Mechanism of p38 MAP kinase activation in vivo Genes Dev. 17 2003 1969 1978
15. S. Sriskandan, and D.M. Altmann The immunology of sepsis J. Pathol. 214 2008 211 223
16. I. Herzum, and H. Renz Inflammatory markers in SIRS, sepsis and septic shock Curr. Med. Chem. 15 2008 581 587
17. A.B. Waxman, and N. Kolliputi IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins Am. J. Respir. Cell Mol. Biol. 41 2009 385 396
18. N. Kolliputi, and A.B. Waxman IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation Am. J. Physiol. Lung Cell. Mol. Physiol. 297 2009 L6 L16
19. M. Rocha, R. Herance, S. Rovira, A. Hernandez-Mijares, and V.M. Victor Mitochondrial dysfunction and antioxidant therapy in sepsis Infect. Disord. Drug Targets 12 2012 161 178
20. D. Brealey, S. Karyampudi, T.S. Jacques, M. Novelli, R. Stidwill, V. Taylor, R.T. Smolenski, and M. Singer Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 2004 R491 R497
21. + lymphocyte adenosine triphosphate determination in sepsis: a cohort study Crit. Care 14 2010 R110
22. V. Vanasco, N.D. Magnani, M.C. Cimolai, L.B. Valdez, P. Evelson, A. Boveris, and S. Alvarez Endotoxemia impairs heart mitochondrial function by decreasing electron transfer, ATP synthesis and ATP content without affecting membrane potential J. Bioenerg. Biomembr. 44 2012 243 252
23. B.M. Tang, A.S. McLean, I.W. Dawes, S.J. Huang, and R.C. Lin The use of gene-expression profiling to identify candidate genes in human sepsis Am. J. Respir. Crit. Care Med. 176 2007 676 684
24. N.V. Gorbunov, B.R. Garrison, D.P. McDaniel, M. Zhai, P.J. Liao, D. Nurmemet, and J.G. Kiang Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis Oxid. Med. Cell. Longevity 2013 2013 186795
25. H. Bayir, and V.E. Kagan Bench-to-bedside review: mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory Crit. Care 12 2008 206
26. J. Bereiter-Hahn Do we age because we have mitochondria? Protoplasma 251 2014 3 23
27. C.D. Savage, G. Lopez-Castejon, A. Denes, and D. Brough NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury Front. Immunol. 3 2012 288
28. A. Mathew, T.A. Lindsley, A. Sheridan, D.L. Bhoiwala, S.F. Hushmendy, E.J. Yager, E.A. Ruggiero, and D.R. Crawford Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration J. Alzheimer's Dis. 30 2012 617 627
29. D. Verma, M. Lerm, R. Blomgran Julinder, P. Eriksson, P. Soderkvist, and E. Sarndahl Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? Arthritis Rheum. 58 2008 888 894
30. J.M. Abais, C. Zhang, M. Xia, Q. Liu, T.W. Gehr, K.M. Boini, and P.L. Li NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia Antioxid. Redox Signaling 18 2013 1537 1548
31. F. Martinon Detection of immune danger signals by NALP3 J. Leukocyte Biol. 83 2008 507 511
32. Z. Zhang, X. Xu, J. Ma, J. Wu, Y. Wang, R. Zhou, and J. Han Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses J. Immunol. 190 2013 3517 3524
33. K. Nakahira, J.A. Haspel, V.A. Rathinam, S.J. Lee, T. Dolinay, H.C. Lam, J.A. Englert, M. Rabinovitch, M. Cernadas, H.P. Kim, K.A. Fitzgerald, S.W. Ryter, and A.M. Choi Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Nat. Immunol. 12 2011 222 230
34. S.M. Parikh Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury Curr. Opin. Crit. Care 19 2013 554 559
35. H.F. Galley Bench-to-bedside review: targeting antioxidants to mitochondria in sepsis Crit. Care 14 2010 230
36. H.M. Choi, S.K. Jo, S.H. Kim, J.W. Lee, E. Cho, Y.Y. Hyun, J.J. Cha, Y.S. Kang, D.R. Cha, W.Y. Cho, and H.K. Kim Glucocorticoids attenuate septic acute kidney injury Biochem. Biophys. Res. Commun. 435 2013 678 684
37. B.M. Klebl Chemical kinomics - a target gene family approach in chemical biology Drug Discovery Today Technol. 1 2004 25 34
38. M. Fisk, P.R. Gajendragadkar, K.M. Maki-Petaja, I.B. Wilkinson, and J. Cheriyan Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease Am. J. Cardiovasc. Drugs 14 2014 155 165
39. Y. Liao, X. Wang, M. Huang, J.P. Tam, and D.X. Liu Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus Virology 420 2011 106 116