Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses

Journal of Immunology

Volumn 190, Issue 7, 2013, Pages 3517-3524

  Zhang, Zhirong ^a   Xu, Xiaozheng ^a   Ma, Jianhui ^a   Wu, Jianfeng ^a   Wang, Yanhai ^a   Zhou, Rongbin ^b   Han, Jiahuai ^a  

^a XIAMEN UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BINDING PROTEIN; CRYOPYRIN; CYTOKINE; GAMMA AMINOBUTYRIC ACID A RECEPTOR ASSOCIATED PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MITOCHONDRIAL DNA; NLRP3 INFLAMMASOME; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; GABARAP GENE; GENE; GENE DELETION; IN VITRO STUDY; INFLAMMATION; MORTALITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPSIS;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ENZYME ACTIVATION; GENE DELETION; GENES, LETHAL; GENETIC PREDISPOSITION TO DISEASE; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; REACTIVE OXYGEN SPECIES; SEPSIS;

EID: 84875445306     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202628     Document Type: Article

References (41)

1. Chalupka, A. N., and D. Talmor. 2012. The economics of sepsis. Crit. Care Clin. 28: 57-76, vi (vi.).
2. 1992. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20: 864-874.
3. Bone, R. C., R. A. Balk, F. B. Cerra, R. P. Dellinger, A. M. Fein, W. A. Knaus, R. M. Schein, and W. J. Sibbald; ACCP/SCCM Consensus Conference Committee. 2009. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 136(5 Suppl.): e28.
4. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature 420: 885-891.
5. Singer, M., V. De Santis, D. Vitale, and W. Jeffcoate. 2004. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 364: 545-548.
6. Pathan, N., C. A. Hemingway, A. A. Alizadeh, A. C. Stephens, J. C. Boldrick, E. E. Oragui, C. McCabe, S. B. Welch, A. Whitney, P. O'Gara, et al. 2004. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 363: 203-209.
7. Hotchkiss, R. S., and I. E. Karl. 2003. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348: 138-150.
8. Bozza, F. A., J. I. Salluh, A. M. Japiassu, M. Soares, E. F. Assis, R. N. Gomes, M. T. Bozza, H. C. Castro-Faria-Neto, and P. T. Bozza. 2007. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit. Care 11: R49.
9. Gordon, S. 2002. Pattern recognition receptors: doubling up for the innate immune response. Cell 111: 927-930.
10. Meylan, E., J. Tschopp, and M. Karin. 2006. Intracellular pattern recognition receptors in the host response. Nature 442: 39-44.
11. Medzhitov, R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449: 819-826.
12. Tschopp, J., and K. Schroder. 2010. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat. Rev. Immunol. 10: 210-215.
13. Wang, H., F. K. Bedford, N. J. Brandon, S. J. Moss, and R. W. Olsen. 1999. GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton. Nature 397: 69-72.
14. Coyle, J. E., S. Qamar, K. R. Rajashankar, and D. B. Nikolov. 2002. Structure of GABARAP in two conformations: implications for GABAA receptor localization and tubulin binding. Neuron 33: 63-74.
15. Kneussel, M., S. Haverkamp, J. C. Fuhrmann, H. Wang, H. Wässle, R. W. Olsen, and H. Betz. 2000. The γ-aminobutyric acid type A receptor (GABAAR)- associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc. Natl. Acad. Sci. USA 97: 8594-8599.
16. Abeliovich, H., W. A. Dunn, Jr., J. Kim, and D. J. Klionsky. 2000. Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J. Cell Biol. 151: 1025-1034.
17. Nakatogawa, H., Y. Ichimura, and Y. Ohsumi. 2007. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130: 165-178.
18. Weidberg, H., E. Shvets, T. Shpilka, F. Shimron, V. Shinder, and Z. Elazar. 2010. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J. 29: 1792-1802.
19. He, H., Y. Dang, F. Dai, Z. Guo, J. Wu, X. She, Y. Pei, Y. Chen, W. Ling, C. Wu, et al. 2003. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J. Biol. Chem. 278: 29278-29287.
20. Xie, Z., U. Nair, and D. J. Klionsky. 2008. Atg8 controls phagophore expansion during autophagosome formation. Mol. Biol. Cell 19: 3290-3298.
21. Weidberg, H., T. Shpilka, E. Shvets, and Z. Elazar. 2010. Mammalian Atg8s: one is simply not enough. Autophagy 6: 808-809.
22. Behrends, C., M. E. Sowa, S. P. Gygi, and J. W. Harper. 2010. Network organization of the human autophagy system. Nature 466: 68-76.
23. Shvets, E., A. Abada, H. Weidberg, and Z. Elazar. 2011. Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes. Autophagy 7: 683-688.
24. Weidberg, H., E. Shvets, and Z. Elazar. 2011. Biogenesis and cargo selectivity of autophagosomes. Annu. Rev. Biochem. 80: 125-156.
25. Bjørkøy, G., T. Lamark, A. Brech, H. Outzen, M. Perander, A. Overvatn, H. Stenmark, and T. Johansen. 2005. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171: 603-614.
26. Shvets, E., E. Fass, R. Scherz-Shouval, and Z. Elazar. 2008. The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J. Cell Sci. 121: 2685-2695.
27. Jiang, S., B. Heller, V. S. Tagliabracci, L. Zhai, J. M. Irimia, A. A. DePaoli- Roach, C. D. Wells, A. V. Skurat, and P. J. Roach. 2010. Starch binding domaincontaining protein 1/genethonin 1 is a novel participant in glycogen metabolism. J. Biol. Chem. 285: 34960-34971.
28. Levine, B., N. Mizushima, and H. W. Virgin. 2011. Autophagy in immunity and inflammation. Nature 469: 323-335.
29. Nakahira, K., J. A. Haspel, V. A. Rathinam, S. J. Lee, T. Dolinay, H. C. Lam, J. A. Englert, M. Rabinovitch, M. Cernadas, H. P. Kim, et al. 2011. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12: 222-230.
30. Saitoh, T., N. Fujita, M. H. Jang, S. Uematsu, B. G. Yang, T. Satoh, H. Omori, T. Noda, N. Yamamoto, M. Komatsu, et al. 2008. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 456: 264-268.
31. Zambrowicz, B. P., G. A. Friedrich, E. C. Buxton, S. L. Lilleberg, C. Person, and A. T. Sands. 1998. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392: 608-611.
32. O'Sullivan, G. A., M. Kneussel, Z. Elazar, and H. Betz. 2005. GABARAP is not essential for GABA receptor targeting to the synapse. Eur. J. Neurosci. 22: 2644- 2648.
33. Le Feuvre, R. A., D. Brough, Y. Iwakura, K. Takeda, and N. J. Rothwell. 2002. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J. Biol. Chem. 277: 3210-3218.
34. Bergsbaken, T., S. L. Fink, and B. T. Cookson. 2009. Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7: 99-109.
35. Tal, M. C., M. Sasai, H. K. Lee, B. Yordy, G. S. Shadel, and A. Iwasaki. 2009. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc. Natl. Acad. Sci. USA 106: 2770-2775.
36. Zhou, R., A. S. Yazdi, P. Menu, and J. Tschopp. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature 469: 221-225.
37. Shimada, K., T. R. Crother, J. Karlin, J. Dagvadorj, N. Chiba, S. Chen, V. K. Ramanujan, A. J. Wolf, L. Vergnes, D. M. Ojcius, et al. 2012. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36: 401-414.
38. Pétrilli, V., S. Papin, C. Dostert, A. Mayor, F. Martinon, and J. Tschopp. 2007. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14: 1583-1589.
39. Zhou, R., A. Tardivel, B. Thorens, I. Choi, and J. Tschopp. 2010. Thioredoxininteracting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11: 136-140.
40. Sorbara, M. T., and S. E. Girardin. 2011. Mitochondrial ROS fuel the inflammasome. Cell Res. 21: 558-560.
41. Okazaki, N., J. Yan, S. Yuasa, T. Ueno, E. Kominami, Y. Masuho, H. Koga, and M. Muramatsu. 2000. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res. Mol. Brain Res. 85: 1-12.