Pipette tip solid-phase extraction and high-performance liquid chromatography for the determination of flavonoids from Epimedii herba in rat serum and application of the technique to pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 990, Issue , 2015, Pages 64-72

  Wang, Nani ^a   Huang, Xiaowen ^a   Wang, Xuping ^a   Zhang, Yang ^a   Wu, Renjie ^a   Shou, Dan ^a  

^a Zhejiang Academy of Traditional Chinese Medicine   (China)

Author keywords

Epimedii herba; Flavonoids; Pharmacokinetics; Pipette tip extraction; Serum

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHY; FLAVONOIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUIDS; PHARMACOKINETICS; PHASE SEPARATION; RATS;

CONVENTIONAL EXTRACTION; EPIMEDII HERBA; OPTIMUM EXTRACTION CONDITIONS; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC STUDIES; SERUM; SIMULTANEOUS ANALYSIS; SOLID-PHASE EXTRACTION;

EXTRACTION;

EPIMEDII HERBA EXTRACT; EPIMEDIN A; EPIMEDIN B; EPIMEDIN C; FLAVONOID; ICARIIN; PLANT EXTRACT; SORBENT; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; EXTRACTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MALE; NONHUMAN; PIPETTE TIP SOLID PHASE EXTRACTION; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; EPIMEDIUM; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; WISTAR RAT;

RATTUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; EPIMEDIUM; FEMALE; FLAVONOIDS; LINEAR MODELS; MALE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION;

EID: 84926465537     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.03.012     Document Type: Article

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