In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from Gan-kang granules and extracts of Herba Epimedii, Nepal dock root, Ficus hirta yahl

Journal of Ethnopharmacology

Volumn 124, Issue 3, 2009, Pages 522-529

  Li, Yihui ^a   Duan, Juping ^a   Guo, Tingting ^a   Xie, Wei ^a   Yan, Shineng ^a   Li, Bo ^a   Zhou, Yanqin ^a   Chen, Yuxiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Emodin; Gan kang granules; Icariin; Pharmacokinetics; Psorale

Indexed keywords

CHINESE DRUG; EMODIN; EPIMEDIUM BREVICORNUM EXTRACT; ICARIIN; PLANT EXTRACT; PSORALEA CORYLIFOLIA EXTRACT; PSORALEN; RUMEX JAPONICUS EXTRACT; UNCLASSIFIED DRUG;

ACTINIDIA ARGUTA; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ASTRAGALUS MONGBOLICUS; CONTROLLED STUDY; CRATAEGUS PINNATIFIDA; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG SOLUBILITY; DRUG STRUCTURE; EPIMEDIUM BREVICORNUM; HALF LIFE TIME; HERB; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISODON LOPHANTHOIDES; MAHONIA BEALEI; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PSORALEA CORYLIFOLIA; RAT; RUMEX JAPONICUS; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; EMODIN; FICUS; FICUSIN; FLAVONOIDS; PLANT EXTRACTS; QUALITY CONTROL; RATS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; RUMEX; SPECTROPHOTOMETRY, ULTRAVIOLET;

FICUS HIRTA; RATTUS; RUMEX;

EID: 67650667424     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.05.008     Document Type: Article

References (38)

1. Atsuyoshi N., Kubota K., and Toshihiko O. Antimicrobial components trachtysone and 2-methoxystypandrone in Rumex japonicus Houtt. Journal of Agriculture and Food Chemistry 41 (1993) 1772
2. Basile A., Vuotto M.L., and Violante U. Antibacterial activity in actinidia chinensis, Feijoa sellowiana and Aberia caffra. International Journal of Antimicrobial Agents 8 (1997) 199-203
3. Bhattaram V.A., Graefe U., and Kohlert C. Pharmacokinetics and bioavailability of herbal medicinal products. Phytomedicine 9 (2002) 1-33
4. Cemakoca M., and Kostalova D. Antimiicrobial activity of berberinum constituent of Mahoia aquifolium. Folia Microbiologica 47 (2002) 375-378
5. Chen D.X., and Pan L.Q. An anti-tumor plant: Actinidia arguta roots. Journal of Chinese Medicinal Materials 27 (2004) 86-87
6. Chen J.P., Ji W.Y., and Chen Y.X. Effect of Gan-kang granula on immunological liver injury in mice. 16th Chinese Pharmaceutical Association Annual Meeting Proceedings (2006)
7. Cheng S., Qiu F., Wang S.H., and He J.Q. HPLC analysis and pharmacokinetics of icariin in rats. Journal of Separation Science 30 (2007) 1307-1312
8. Ding L.J., Zhou Y.F., and Lin N. Extracting of flavone from Rabdosin serra Hara and its effects on scavenging of hydroxyl radicals. Food and Machinery 20 (2004) 13-14
9. Guo X.R., Chen X.H., Li L., Shen Z.D., Wang X.L., Zheng P., Duan F.X., Ma Y.F., and Bi K.S. LC-MS determination and pharmacokinetic study of six phenolic components in rat plasma after taking traditional Chinese medicinal-preparation: guanxinning lyophilized powder for injection. Journal of Chromatography B 873 (2008) 51-58
10. Han Y. A summary of the basic studies on Radix Astragali Sell Hedysari. Journal of Henan University of Chinese Medicine 18 (2003) 86-88
11. Huang X., Jiang Y.P., Yang Y.C., and Ma Y. Metabolism and pharmacokinetics of psoralen from malaytea scurfpea (Psoralea corylifolia) in mice. Chinese Traditional and Herbal Drugs 22 (1991) 361-363
12. Jiang B., Liu Z.Q., and Zeng Y.N. Studies on chemical composition of Ficus hirta yahl. Chinese Traditional and Herbal Drugs 36 (2005) 1141-1142
13. Jiang Y.L., Wang X.L., Xue S.G., and Zhou S.H. Extraction of berberine hydrochloride from Mahonia bealei (Fort) Carr. China Journal of Chinese Materia 18 (1993) 347-348
14. Jin Y.R., Gui M.Y., and Ma B.R. Chemical constituents of Actinidia arguta roots. Chinese Pharmaceutical Journal 33 (1998) 402-404
15. Kim J.H., Mun Y.J., Im S.J., Han J.H., Lee H.S., and Woo W.H. Effects of the aqueous extract of Epimedii Herba on the antibody responses in mice. International Immunopharmacology 1 (2001) 935-944
16. Lee J.H., Jong M.K., and Chungsook K. Pharmacokinetic analysis of rhein in Rheum undulatum L. Journal of Ethnopharmacology 84 (2003) 5-9
17. Lee Y.S., Han O.K., and Chan W.P. Immunomodulatory effects of aqueous-extracted Astragali radix in methotrexate-treated mouse spleen cells. Journal of Ethnopharmacology 84 (2003) 193-198
18. Li R.F., Zhou Y.Z., and Qiao L. Chemical constituents of Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao. Journal of ShenYang Pharmaceutical University 24 (2007) 20-24
19. Lin K., Zhang T.P., and Zhang H.Y. Separation and purification of ursolic Ac-id(UA) from hawthorn fruits and hypolipidemic effect of UA on mice. Natural Products Research and Development 19 (2007) 10522-11054
20. Liu C.L., Xu H.H., and Wu Q.H. Experimental study on the immunological function of mice by Ficus hirta yahl. Chinese Traditional and Herbal Drugs 27 (2004) 367-368
21. Liu J.X., Gao H.X., and Wang Z.M. Studies on the chemical constituents from Isodon Serra (Maxim.) Kudo. Modern Chinese Medicine 9 (2007) 10-11
22. Lu T., Song J., Huang F., Deng Y.X., Xie L., Wang G.J., and Liu X.D. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. Journal of Ethnopharmacology 110 (2007) 412-418
23. Ou W.P., Fu H.Q., and Huang S.T. HPLC determination of psoralen and pharmacokinetics study. Traditional Chinese Drug Research and Clinical Pharmacology 2 (2000) 107-109
24. Pan Y., Lin Q.Y., Ou X.H., and Yan J. Research on total flavonoids' hepatic protection of Fructus Crataegi. Journal of Guangxi Traditional Chinese Medical University 17 (2004) 7-10
25. Pang Z.G., Wang B.Q., and Qi Y. Study on the pharmacokinetics of psoralen and isopsoralen by fluorometry. Chinese Journal of Analytical Chemistry 29 (2001) 146-149
26. Si D.D., Sun X.H., Qi D.D., Chen X.H., and Bi K.S. Determination and pharmacokinetics of isoferulic acid in rat plasma by high-performance liquid chromatography after oral administration of isoferulic acid and Rhizoma Cimicifugae extract. Journal of Pharmaceutical and Biomedical Analysis 47 (2008) 140-145
27. Tang Y.J., Yang J.Y., and Chen Y.X. Clinical observation of Gan-kang granula to chronic HB. China Journal of Modern Medicine 15 (2005) 3193-3196
28. Tu Y., Zhu L., Wang G.J., Zhao L.H., and Xiang B.R. Development and validation of a LC-ESI-MS assay for determination of icariin in rat plasma after administration of Herba epimedii. Chromatographia 67 (2008) 591-597
29. Vuotoo M.L., Basile A., Moscatiello V., Violante U., Sorbo S., and Martone G. Antibacterial activity in Actinidia chinensis, Feijoa sellowiana and Aberia caffra. International Journal of Antimicrobial Agents 8 (1997) 199-203
30. Wang Y.M. Research of Mahonia bealei (fort.) Carr. Research of Traditional Chinese Medicine 18 (2002) 45
31. Xia A.L., Wu H.L., Zhu S.H., Han Q.J., Zhang Y., and Yu R.Q. Determination of psoralen in human plasma using excitation-emission matrix fluorescence coupled to second-order calibration. Analytical Sciences 24 September (2008) 1171-1176
32. Xu, S.Y., Bian, R.L., Chen, X., 2002. Methodology of Pharmacological Experiment. People's Sanitation Press, Beijing, pp. 226-240.
33. Xu M.J., Wang G.J., Xie H.T., Huang Q., Wang W., and Jia Y.W. Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats. Journal of Ethnopharmacology 115 (2008) 483-488
34. Yan W.M., Fu Y., and Ma Y. Studies on flavones of epimedium brevicorum maxim. China Journal of Chinese Material Medica 23 (1998) 735-736
35. Ye L.K., Chen J.M., and Liu S.H. Pharmacokinetics of icariin in rats. Chinese Pharmaceutical Journal 34 (1999) 33-36
36. Yu T.M., and Yu C.S. Fructus crataegi. Food and Drug 8 (2006) 75-76
37. Zhang C.F., Zhang M., and Wang Z.T. Studies on Constituents from Ligularia narynensis. Journal of Chinese Medicinal Materials 28 (2005) 104-105
38. Zhang W., Sheng Y.X., and Zhang J.L. Determination and pharmacokinetics of gastrodin and phydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography-electrospray ionization mass spectrometric method. Phytomedicine 15 (2008) 844-850